ID W5JR61_ANODA Unreviewed; 447 AA.
AC W5JR61;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Apoptosis 1 inhibitor {ECO:0000313|EMBL:ETN65793.1};
GN ORFNames=AND_002432 {ECO:0000313|EMBL:ETN65793.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN65793.1};
RN [1] {ECO:0000313|EMBL:ETN65793.1, ECO:0000313|Proteomes:UP000000673}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN65793.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN65793.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
RN [4] {ECO:0000313|EnsemblMetazoa:ADAC002432-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the IAP family. {ECO:0000256|ARBA:ARBA00006672}.
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DR EMBL; ADMH02000578; ETN65793.1; -; Genomic_DNA.
DR AlphaFoldDB; W5JR61; -.
DR STRING; 43151.W5JR61; -.
DR EnsemblMetazoa; ADAC002432-RA; ADAC002432-PA; ADAC002432.
DR VEuPathDB; VectorBase:ADAC002432; -.
DR VEuPathDB; VectorBase:ADAR2_002458; -.
DR eggNOG; KOG1101; Eukaryota.
DR HOGENOM; CLU_016347_1_1_1; -.
DR OMA; CMDENIA; -.
DR OrthoDB; 383715at2759; -.
DR Proteomes; UP000000673; Unassembled WGS sequence.
DR CDD; cd00022; BIR; 2.
DR CDD; cd16510; RING-HC_IAPs; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001370; BIR_rpt.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR10044:SF174; DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 1; 1.
DR PANTHER; PTHR10044; INHIBITOR OF APOPTOSIS; 1.
DR Pfam; PF00653; BIR; 2.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00238; BIR; 2.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57924; Inhibitor of apoptosis (IAP) repeat; 2.
DR PROSITE; PS01282; BIR_REPEAT_1; 1.
DR PROSITE; PS50143; BIR_REPEAT_2; 2.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}; Reference proteome {ECO:0000313|Proteomes:UP000000673};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 400..435
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 139..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 311..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..378
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 447 AA; 48917 MW; 0F99E59E6F366F35 CRC64;
MTAQVQSLPI DQTDNKHSNE ELAYLSADYF HIEQNRLQTF DQWPVTFIRK EELARYGFYY
TGTDDTVKCH FCRVEIGMWE EHDNVIEEHL RWSPYCPLLR KRPTNNVALD RNFLANVPEP
SYDVCGINVR THSYAENASD RMSGDSWSGA SDISSGSNSI NGNSIVGEAS TSTISTDRSG
LQLQMRHGGD MEAPLAGGAA ASAFCSHVTS MVQTCRPEYP MYAIEADRLK SFEDWPTSMS
QKPQQLSDAG FFYTGKSDRV KCFSCGGGLK DWEQGDDPWE QHGIWYSNCH YLKLIKGREF
IDRCLAMKAD EEAASSQPST SGVSSNASSL MSTSPATSSG ISSPAPGDDA RTSSSNSNST
ETTTTTTTTV TPKAASSTIG SAVEGDDDAA SRGISDGKIC KICYVNEYNI AFLPCGHVVA
CAKCASSVTK CPMCQQPFYN VLKLYLS
//
