ID W5JTE4_ANODA Unreviewed; 1603 AA.
AC W5JTE4;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Sterol regulatory element-binding protein cleavage-activating protein {ECO:0000256|ARBA:ARBA00019541};
GN ORFNames=AND_001649 {ECO:0000313|EMBL:ETN66558.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN66558.1};
RN [1] {ECO:0000313|EMBL:ETN66558.1, ECO:0000313|Proteomes:UP000000673}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN66558.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN66558.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
RN [4] {ECO:0000313|EnsemblMetazoa:ADAC001649-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle
CC membrane {ECO:0000256|ARBA:ARBA00004557}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004557}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the WD repeat SCAP family.
CC {ECO:0000256|ARBA:ARBA00007410}.
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DR EMBL; ADMH02000424; ETN66558.1; -; Genomic_DNA.
DR STRING; 43151.W5JTE4; -.
DR EnsemblMetazoa; ADAC001649-RA; ADAC001649-PA; ADAC001649.
DR VEuPathDB; VectorBase:ADAC001649; -.
DR VEuPathDB; VectorBase:ADAR2_004765; -.
DR eggNOG; KOG1933; Eukaryota.
DR HOGENOM; CLU_006510_0_0_1; -.
DR OMA; WIETGIS; -.
DR OrthoDB; 2875749at2759; -.
DR Proteomes; UP000000673; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032934; F:sterol binding; IEA:InterPro.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0032933; P:SREBP signaling pathway; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR030225; SCAP.
DR InterPro; IPR000731; SSD.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR46378; STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR46378:SF1; STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50156; SSD; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000673};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT TRANSMEM 451..467
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 479..508
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 514..535
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 562..580
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 947..969
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 450..608
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REPEAT 1009..1048
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1481..1520
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 96..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 408..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1065..1106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1235..1262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1361..1383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..73
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..430
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1603 AA; 174869 MW; EBCB6B75BC9EA5A3 CRC64;
MTASSSVESL YPVAGSSGVT GERVWSNGTA QRVVSRPQGV TSQHHQPSHQ SSQQPGVTGG
RLPQPSSTMP TGPITARKPP LAQAAASGVG TSAYRGLSAV GKERTERKGS QPTTLPSRVS
QLYYKHGLFL SSYPTTTTSI ALAIIIFCCY PLLNIPLPGT IPTKVIFPHT ESISENLHLS
SANLSSEFYN PFSPFTGGNM FNIYNISLET PFPWARIEPL LYVQQIILRS SVVPWEADLL
LTDAFRGPLY EVFKLVEMIR NHEDVNKITL SHLCLHVENV KRSSQQTLFP EYNCLLLSPA
NLWQQNLQAF NKDSNLLNSI FVNHNLQKSK VSTAEMLFGI SLCDTGVKRY PMRVRPRVIQ
YAVTLILREN NPSYIQSLKQ KLIRAYPLHQ KEIDGSLPVE DAAKLAEQSE AGSPSPSAST
SNQQPSALGT VPQPQSIMYI FYPGEFNWHE VLPQCIAFCV LFSYVYFSVR KIEAIRSRLM
LASCAVLTVL GSLLMSLGLC FFFGLTISFQ SKGVYPYLVI LVGLENVLVI TKSVLTTDNN
LDVKIRVAQG LSREGWSITK NLLTEITILT GGLATFVPVI QEFCIFAMVG LVSDFLLQML
FFATVLALDI KRVEYSAEVR RLPKMLYFNS ELRRGAGAGA MPGSASAPLD VARNGSMHRS
RSHPKLAGLE QTMAGHKKPT GSLSGGSAGG KAPAKIPKRL RIVNFWARTR FFQRGFMIWM
VLWISNIIYN AGLIEELFVI DRNITAAGGG SHATSGASMD AAGSAMNRFE QGLSGAEFGG
GVGNGGETGG DTSIGRSPEM DRFGYSKLAA AAGAGVEGML GGGGGGDRAI PNVTEQLNRL
KHPDYYETVY QLSNFHWSSI LKQYNVSLSG RYVTVLPAIK LSHAVSPQTA VTLRNADEKA
PHHFQWKALA VALDPLDFSD TDPGDGVPGG IGPIGNAPFY PKTPMEILLT CMLLVVSTFV
VTYTMVVLYR CVCTRNYAEW RASWHSESSE GEADAKPEQC LLEGVPIQVN GHAHRIECLV
TDGSMIASSC LQGQVKVWDV GSGELMAEID RCSYFEMQQQ LYHQHNQHHR ASSGSSSPPG
SALPSPTTGV LLRNDESGNP ITGVQEVFPS PSTSFGSLTH DESLVQATPP YSSSPPLNAA
GGYVSFKLKK KLHFNFTTNL QDDTVAARVQ TDPKLFDFRA QYDRFFTSCA PLPRNAGGEA
ADLRNRFTRN GLRDTKQGLM MNASYAMAPE QGVNQQQWTG GRPTALSSEC PRPPGTVSPP
QKHHRVSPIW CLDFLDNLIV IGCADGRLEF WEGTTGSFKC IYESETTHNN GVTGIKLTGD
RVIAARLSGR IDFFRLETYT QGRQIDWGFT STYRRTHMRT GSAGSLSSFQ SSSTTGSNPS
GSAASASEEL RCILEFQQQG HQQPVTCLEV AGNIAMTGSQ DHTLKVFRVD NHQLLYTLHG
HCGPITCLFI DQWQSGMAGS GSQDGLLCVW ELTTGACMYK IQAHDDSIVA LSGSPSYVIS
LGLDERIRVW DRFQGHPLST ITVSHAYSAL IMLTPSLLVT GKPGALVVWD ARSGEVVREV
KLDCSNMQLC PKIMLPAGGS VICDYGNQMR IVRFPLVAAD KCD
//
