ID W5JV11_ANODA Unreviewed; 3290 AA.
AC W5JV11;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
GN ORFNames=AND_001415 {ECO:0000313|EMBL:ETN66790.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN66790.1};
RN [1] {ECO:0000313|EMBL:ETN66790.1, ECO:0000313|Proteomes:UP000000673}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN66790.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN66790.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
RN [4] {ECO:0000313|EnsemblMetazoa:ADAC001415-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADMH02000378; ETN66790.1; -; Genomic_DNA.
DR STRING; 43151.W5JV11; -.
DR EnsemblMetazoa; ADAC001415-RA; ADAC001415-PA; ADAC001415.
DR VEuPathDB; VectorBase:ADAC001415; -.
DR VEuPathDB; VectorBase:ADAR2_007588; -.
DR eggNOG; KOG0940; Eukaryota.
DR HOGENOM; CLU_000372_1_0_1; -.
DR OMA; TYEMIMV; -.
DR OrthoDB; 4609983at2759; -.
DR Proteomes; UP000000673; Unassembled WGS sequence.
DR CDD; cd13248; PH_PEPP1_2_3; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR040392; PKHA4-7_PH.
DR PANTHER; PTHR12752:SF9; KRAMER, ISOFORM I; 1.
DR PANTHER; PTHR12752; PHOSPHOINOSITOL 3-PHOSPHATE-BINDING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000000673}.
FT DOMAIN 527..626
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 98..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 316..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 394..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 470..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 633..725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 739..764
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 844..882
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 901..1018
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1049..1186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1304..1346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1391..1459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1493..1549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1585..1617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1632..1655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1702..1731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1798..1825
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1853..1966
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2022..2056
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2128..2147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2405..2435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2447..2499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2580..2606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2713..2744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2904..2940
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 792..830
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3107..3134
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3214..3241
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 98..131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..495
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..702
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 901..964
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1001..1015
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1049..1067
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1085..1105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1147..1164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1166..1186
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1321..1344
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1400..1420
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1424..1448
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1500..1543
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1634..1649
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1702..1722
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1801..1821
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1853..1881
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1923..1942
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1943..1957
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2459..2499
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2716..2744
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2904..2919
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2921..2940
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3290 AA; 355760 MW; 53CBEA9B7E6BB1EA CRC64;
MFSCLWQLWD WIDPPTFTTM ESKKLQQLQQ ANSHLAPMPQ MKGPGFQQAP PGGYDYGTSG
ATGLGHGRSP MYVATGGGPG TAAAGQYQAY GANYGQHPSL RSPYSTGSPK SSLSTNSGAL
YGATDGGELS SNSGGDRHLL HPHHQQQHYR SNTLGASSYG FEQQQQQQHL QRVSSPSSSG
ERERLYQTAP LVRNAAVGGA VGTPHSVASN SSNAHAPMSK LELQFQQLQR EKIQQQIKTA
TEAIAHQQQT FALRQQLNPP VPNYHLKQNL LQNLSQHHQQ QIQQQQQQQQ QHQQQQQQQQ
QQQQQLQQLQ QKQQQQHQQL QKQNPPQQHL HPQQAAKQQT ERHQQQQMQQ QQQMQHSMKQ
QHQQRYPGNG NHNRNVPPSS LNLLNHCQPA ANENDKMVRG NHHPSGSSSV ATGAYPVGDE
DALYQKSGGF SSVASPLAAG ANGEIIIQQN IPGQVVNQAC QTQISSLVTG GSGKQQQQQQ
QQSIKPSPSD TLSSPSHDSI ERKRSTGGSG QQHTLKSPVT KRPANAVVAL SGWLYKQGSE
GLKVWRRRWF VLSEYVLYYY KGPEEEKLLG TVLLPSYRVS ACFPEDKIYR KFAFKCEHAN
MRTFVFAAEN GESMSQWVRA LTLATMMMQG SGAGEMDSAN LQQQQQVSSD TSSGTTSGGQ
SHGSSDTAKM AQHAGKQPVS NGSNGAGGTA TNQESNSLPQ PLYANAPPKP RRVNDAGYSS
PSPDHVILND RYDHMIQQQQ QQQLVGAGQF PSGSAPGAPM NNRMGGAGSM NAILSANAIY
GDPKRIERDL YIQKLIEQQQ QSQLNAQKQQ QQQQQQQQQQ QQQQQQHQQQ QQVGAMQASP
LHGQMMRGNA GLSTNPFLYP ASNDRRTPDT YGPPNSAVDP KHMSDYEDIY NLTMLSKSLP
TNAHGPVDGS TSGSYKRPAS PQRYTGSGGI TSGSYGTPNT SYSGNPFEAP AMTPQHQVQM
RSPRSIPPSI PRPHSADFLD YEARHPLNQG PGASGNDEHQ STPHRTPRPK SSLDINRTPD
HYYYSEASYA EKMRLQSASY LQRTANNSVG SVGVSRKQRS DDTQGSFVGG TIPRDGLLYR
SGSGKLFPNT PQHGQPQQQH NHIQYMASEG DFMHPEGGGS LSMPRPSATG DRIASGARPS
VQSLKKPGSA AAVQQQQQEQ FARSASARLP RKDEDPGVRD GERKREESMK RLLEWKQRML
QSPLTKKITS GQQSVTMASV ESLHRESNSS LLADRYGGGG GGGTAAEYYG QAQQALAASY
ERQSIGDLTR IGSSAAGSAS HHSSAINVTQ GAYGSQLKLN GGDYNSYSSD DEDGSNFAPA
GRSSPLVSTP ATAPTHQQAG GSSSKGVVVA DARHILTQQH NLRPGFLRKA AAATGGPQEG
STDRMHALTQ TFYSDTGGGD GDDNNDKVDG GDRTDGSLVK LKLDETGSQG SSTRSGQKEL
TVDLSTAQTP GEEMDEEEEV YEDSLVNHAS PSVSPNLSMD ANVYENSFVK PPSRMAEQQE
GIQGKASATR AFGDSNSSGD QPRTVPSGEL GKDNRTSFND GNGNDGLKDG AQQMVYVPVY
KQTASLSIKA LHSDVATLAG SSVQEATPLD ASEKTSPVVE AVEQKAPAAE EDDETEDVFE
YTDDDLDEAL QQAEPDQVES RDAESAEPPD TGTVKRANVA QKTSYVSGAG GGGDEIDDDL
SLQILEGHYM PMTPRKSLIS GATSLTTLSP PPNRNNSGHV EQTGAPAGKL RPSESLTAMD
ILNSIQKSTS NEMQICNSAG AHDENTYIEM TRGTLGKSVF ADELRTSTTY EVIMVPPTGG
MKTKWSNNQD TNRSRDSPNR TPDAATEPLY MELSQLQSRS VISSTSIEAA SKMSNLHPAS
STPVNARSEK LKKTQNTDGS GGGGGAAAGP KLMVPSGGGK KKKKDKNNWP DILMQSSKSD
ESASDSDAYD KIVEEKRKKK PNAPTSAGST ASNVPSKEKK GKASAATIIA GEQHNRIGAS
RSRFSLSDTF RPASYYLGAS GGSGSTHGVT TGGTVFDTLL DSSDSEIMSP PPIPISSVPS
DDPDGDGEYR GVRRREKFRS NEAISDLIKS HAPEKRQSVQ SLVIGNSSHS VAHFGGNLAY
ARRESGSISS NRSSLRSGSQ GLLAPFVGKQ QQQQQQAPVS TSNSPIVLDR YDGVSNASSE
YELLREGATL RGTEQGSNIA AAAGGVGGLD SLSIRSSMTL SETSGSIEWR SRSCMDVSMR
NKRRPISGSS VNCPIELALD GTAPVADFYA PNSSSGGSGL ESQFNRYLSN VNHDMVSESV
QDGSSTATGA EEDEYGMAAS NYSQNGHDNS IYYENVDIMS ASVRTSDGSS VNSSTILSPL
REKNLSLHDA RCQSEYLSTV HEGHSLELVA AAAAAAAAAA TIDTASLSSA MDLDQRSSCT
VRYDYDRSNQ PTIGTPTVES GAYHHHSRNN STLSSECAPY YYSDLQGRSE EEEEQNPPQH
SSSRASSAAG ANNLRSPGTA GSSGGADTLN NQRDPGGLRR QTTGIFHIQN PLNNLKTANL
LLDASATEKH AEIDRKNLYE SDRIVQKDVN KTIAATTLAT GHITNGSATL DRRLTGRLSM
MSSGSTAGTS QERGHPHAGG TSASGGTSIL QHLMAASPSV NISSGDQLWE EDHLWRDNLR
RVSHIHAKSM DNLDHLGTIR SPTTALMAAA ASKKREETDR DGESSAIVEL TKPTVKINRR
DVTYVNEAVA KPATMSNGGG ESSVAGQALS SHCSSTSSSS GNHPKQLAAC LSAGHDEETD
GDDVYVQLAA SNVPSTVRMM VHEAGGTPSG RDGGVHCSSP LSSARESDAV YEVLRDEVNR
YDINRETIRQ WDLMSSGLVN SGSSTGSSST AKAREGAGVG SFTAGSLSAK YMGAFGSIGK
QQSDGIPASP NNNSVSIISN NNSTTARCSS SNSATAGDIL MRNDTDRDNG NAVEDESRHR
PSISVRNVFN IPKVGLTVKP DPSDATYMAH QHHQQQQQQH HQLQMQQQYD MLTAEYYPDD
KYIRPDISFE STHDLYTQAQ LQRAQELNLQ QHYQLQDIDR SLATMQDHQQ QQQQQQHHEQ
LGVASPQTPL GYHHIPTDHH QKVLSENKRS SQLEMKNLIR TAEGDRKADS LVRLEALKQQ
LIELEKQYEK EKPLINLVDN MVKLGSLYRG PMVAGGSKQL QSPESATLDR LEFNQRMQER
RLLQEEQRQW DRTSPNHVEL QSKVQQLYQI DKLMQEESGT LQALQRDKEN LEKALATLKT
RILSREGNIP VASDTARQQQ HTLERELSRV HQLLAANSKK LEKPFPLMRG
//
