ID W5JXY4_ASTMX Unreviewed; 519 AA.
AC W5JXY4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Glycerophosphodiester phosphodiesterase domain containing 2 {ECO:0000313|Ensembl:ENSAMXP00000000194.2};
GN Name=GDPD2 {ECO:0000313|Ensembl:ENSAMXP00000000194.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000000194.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000000194.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the glycerophosphoryl diester phosphodiesterase
CC family. {ECO:0000256|ARBA:ARBA00007277}.
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DR AlphaFoldDB; W5JXY4; -.
DR STRING; 7994.ENSAMXP00000000194; -.
DR Ensembl; ENSAMXT00000000194.2; ENSAMXP00000000194.2; ENSAMXG00000000190.2.
DR eggNOG; KOG2258; Eukaryota.
DR GeneTree; ENSGT00940000159625; -.
DR HOGENOM; CLU_024259_2_0_1; -.
DR InParanoid; W5JXY4; -.
DR OrthoDB; 203377at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000000190; Expressed in zone of skin and 12 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008081; F:phosphoric diester hydrolase activity; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.190; Phosphatidylinositol (PI) phosphodiesterase; 1.
DR InterPro; IPR030395; GP_PDE_dom.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR PANTHER; PTHR23344:SF1; GLYCEROPHOSPHOINOSITOL INOSITOLPHOSPHODIESTERASE GDPD2; 1.
DR PANTHER; PTHR23344; GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE; 1.
DR Pfam; PF03009; GDPD; 1.
DR SUPFAM; SSF51695; PLC-like phosphodiesterases; 1.
DR PROSITE; PS51704; GP_PDE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 32..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 74..98
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 110..131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 151..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 473..495
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 214..463
FT /note="GP-PDE"
FT /evidence="ECO:0000259|PROSITE:PS51704"
SQ SEQUENCE 519 AA; 60394 MW; 9366510A8F2169C1 CRC64;
MRESIVRMCC RGIYSCHWKH PSNDKRRFTC CWFFFVSLMA VLALGWMYVC FVAYNDHNDV
NWEAFRTFSL WVNWYMIMII MYGVLTIYCL LLLLFSLFQF AIKEPLDLHW LHKVLLFLGL
IIVVLGIVMM ACKWTQEWST VRLSLQTTAP FLQLAAVGSL TMISWLVFKS FNRTKKAASR
VFILIALLTV STGIYLSPLL IESPCLIDDL PPKPALLGHR GAPLLAPENT MMSFRKSMEC
GVAAFETDVQ LSKDSKPFLM HDHGNKNLRR TTNVDTVFPN RSNDTSSNFT WEELQMLNAG
DWFVKTDPFW SVSSLSEEER ALARNQTVPL LSDLLNLASQ HSISIIFDLK NDYEDCNHTV
RTILESGIPQ DLIWWLPDAC REYVKKQAKG FRQVYSNVTK MKQNNGKFLN LYYESAAEIR
NLRNENVSIN LWGVHERWLF SLVWCMGATS VTTNTCHVFK DMSRPDWHLK PCYYRIMWIT
ADSVSFLLMV ILFVVQRRRK SRNRIFRLEP EKTIPLLPL
//
