ID W5JYK9_ASTMX Unreviewed; 1371 AA.
AC W5JYK9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=AT-rich interaction domain 4A {ECO:0000313|Ensembl:ENSAMXP00000000419.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000000419.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000000419.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 7994.ENSAMXP00000000419; -.
DR Ensembl; ENSAMXT00000000419.2; ENSAMXP00000000419.2; ENSAMXG00000000379.2.
DR eggNOG; KOG2744; Eukaryota.
DR eggNOG; KOG3001; Eukaryota.
DR GeneTree; ENSGT00940000156159; -.
DR HOGENOM; CLU_007419_1_0_1; -.
DR InParanoid; W5JYK9; -.
DR OrthoDB; 445024at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000000379; Expressed in embryo and 14 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR CDD; cd16882; ARID_ARID4A; 1.
DR CDD; cd18641; CBD_RBP1_like; 1.
DR CDD; cd20390; Tudor_ARID4_rpt2; 1.
DR Gene3D; 2.30.30.140; -; 3.
DR Gene3D; 1.10.150.60; ARID DNA-binding domain; 1.
DR InterPro; IPR012603; ARID4A/B_PWWP.
DR InterPro; IPR001606; ARID_dom.
DR InterPro; IPR036431; ARID_dom_sf.
DR InterPro; IPR047473; CBD_RBP1-like.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR002999; Tudor.
DR InterPro; IPR025995; Tudor-knot.
DR PANTHER; PTHR13964:SF26; AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 4A; 1.
DR PANTHER; PTHR13964; RBP-RELATED; 1.
DR Pfam; PF01388; ARID; 1.
DR Pfam; PF08169; RBB1NT; 1.
DR Pfam; PF11717; Tudor-knot; 1.
DR SMART; SM01014; ARID; 1.
DR SMART; SM00501; BRIGHT; 1.
DR SMART; SM00298; CHROMO; 1.
DR SMART; SM00333; TUDOR; 1.
DR SUPFAM; SSF46774; ARID-like; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS51011; ARID; 1.
PE 4: Predicted;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 334..426
FT /note="ARID"
FT /evidence="ECO:0000259|PROSITE:PS51011"
FT REGION 150..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 304..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 439..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 665..975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1056..1274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1324..1371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..200
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..334
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..565
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..585
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 680..698
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 706..740
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 774..813
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 829..868
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 932..956
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1056..1080
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1085..1102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1117..1131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1162..1176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1227..1242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1341..1371
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1371 AA; 152968 MW; 4B9274102641D893 CRC64;
MLCNPRRVAV SSHIARTIKT HRAGLPQIAI TMRVADEPAY LTVGTDVSAK YRGAFCEAKI
KTVKRMVKVK VVLKADSSSQ IVQDDQVKGP LRVGSTVEVK SPEGASSEAV ISKLTDASWY
TVVFDDGDEK TLRRTSLCLK GERHFAESET LDQLPLTNPE HFGTPVIGKK TNRGRRSSQA
VAEEEKESSS SEEEDEDRRR LNDDLLGKVV VVQSGSDKAS WYHALVVSPS CNDDITVKKD
QCLARSFFDS KFYTVARSDV REMSADTISK SEFSNKKGFE EALKFLQTTQ IPEGWKMDMS
EILESSSSDD GEGKESEEEE KDPEPEEPDD EPDPEERDHF LQQLYKFMED RGTPINKPPV
LGYKDLNLFK LFRLVYHHGG CDNIESGSIW KQVYMDLGIP VLNSAASYNV KTAYKKYLYG
FEEYCRSAKI QFRTVHHNEP RPVTEPEMSV GSEKEEECEE KVDQTPKTKA EPEQDKDKAD
GDESDADEEK IHKEMCSPRG RRRCVATPGK AEGKDSVKPE KVKEEKKKEE VRGGGGEGSG
EEEKEKPEAE NPVKRRSRRH EESDKDSEEE DQDDEEDDEE EEDDVERSRL REREDREDED
GCEESEHSIT GTKVRVKYGK GKTQKIYEAN IKSTETDDGE VLYLVHYYGW NVRYDEWVKA
DRIIWPVDKG GTKKKQKKKV KNKDDGEKEE DKQTKTGVRR GRPPLKSTPP STSRSVSKTP
SSEGRMSNKN SRSTDPSALP NGEGTPRRRT RRSSGMYDSD RASNDSGNSS EDSECEDSPE
KKPECTETTD PATARKLEEE EERQEEKERI EATQAVPECP SSPPEKPAPQ ERSEVEKPEE
DMALSPESDD KSPKSRGKRA RQREPESEDP TPLPATPNHT EPEVPCTLVR QAKKPQETVY
SSPVERMPEK ADSDTDSATE DVSPPESTCI AKRKATEQRT PDKKVRLERK EEPKTLSQPK
TLSPEKRIDT DKCTESMEEV EDALATVAAV AAAAAAAIIV EAPTEEPEVK SEMPSLTREV
QVRMEPLSGL CTLEDPSGVT DEELMPQIGP EALVCHEVDL DDPEEKDKPS GEELLVRREE
KAASVLSAAQ NQSLQPLQPL QPLQPVSHLP HSLAGAPQLC SPSSTPSPDE SHSIKSESDA
TIEVDSVAES QEGIGENGSP HGFDASASSS NSSISLQERD SKDRGQKRLL DCNMISPPKK
LKRNQKRLSA ASTAEKNGAG HSSDSEDLPA MDTSNKLTPV KHSSLAKAQK HSRSPGLVSP
SSKEMEKDKH KDKHGFHAAR AYKWTFQLNE LDNMSSAERI AFLQDKLQEI RKYYMSLKSE
VASIDRRRKR LKKKEREVSH TTASTSSGSS DTGMSPSSAS PTQNTVAVEC R
//
