ID W5JZY6_ASTMX Unreviewed; 706 AA.
AC W5JZY6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=G-protein-signaling modulator 2-like {ECO:0000313|Ensembl:ENSAMXP00000000896.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000000896.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000000896.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GPSM family.
CC {ECO:0000256|ARBA:ARBA00006600}.
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DR AlphaFoldDB; W5JZY6; -.
DR STRING; 7994.ENSAMXP00000000896; -.
DR Ensembl; ENSAMXT00000000896.2; ENSAMXP00000000896.2; ENSAMXG00000000871.2.
DR eggNOG; KOG1130; Eukaryota.
DR GeneTree; ENSGT00940000154667; -.
DR HOGENOM; CLU_012445_1_0_1; -.
DR InParanoid; W5JZY6; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000000871; Expressed in mesonephros and 14 other cell types or tissues.
DR GO; GO:0030695; F:GTPase regulator activity; IEA:InterPro.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR003109; GoLoco_motif.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR45954:SF3; G-PROTEIN-SIGNALING MODULATOR 2; 1.
DR PANTHER; PTHR45954; LD33695P; 1.
DR Pfam; PF02188; GoLoco; 4.
DR Pfam; PF13374; TPR_10; 1.
DR Pfam; PF13424; TPR_12; 2.
DR Pfam; PF13176; TPR_7; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00390; GoLoco; 4.
DR SMART; SM00028; TPR; 6.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50877; GOLOCO; 4.
DR PROSITE; PS50005; TPR; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 93..126
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 272..305
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 410..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 492..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 549..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 653..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 687..706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..464
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 465..480
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..514
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 706 AA; 78273 MW; DA8ED5DF46D3C6A0 CRC64;
MGRRSWVLWF VPRIRAGHMR CCRGENVLKK TVMSLLRKCF GSPKKKKNKR MEASCLELAL
EGERLCKVGD YRAGVSFFES AIQVGTEDLQ ILSAIYSQLG NAYFHLQDYS KALEFHRHDL
TLTRTIGDQL GEAKASGNLG NTLKVLGRYD EAAACCQRHL DISRMLHDKV GQARALYNYG
NVYHAKGKNI CWSGIDPGDF PEEARIALKK ATEFYEANLI IVKELGDRAA QGRTYGNLGN
TQYLLGNFQN AVLAHEQRLL IAKEFGDRAA ERRAYCNLGN AYIFLGQFEV AAEHYKRTLQ
LARQLRDRAV EAQACYSLGN TYTLLQDYER AIDYHLKHLI IAQDLKDRIG EGRACWSLGN
AHTALGNHEQ ALQFAERHLE ISKEIGDRSG ELTARMNLSD LQLVLGLKQN NTTNSNSNSP
VSTDGLTNNG CGSPGTKPRT GRRHSMENME LMKLSRDKSP GSGKEEDTSP NQAKTSPIAK
TSSKLFFISR FKGKKQKANG TSPTKTSPSN SPHSPKLDPK HAPDTLGDEG FFDLLSRFQG
NRMDDQRCSL EGGLSRASAP SSPCETPPVA IRKSISASEA QASEQSGHFL DLLASSQGRR
LDEQRASVAG LPGLHLDQNT SQDVLSKLIA SADSKEPEDD FFDMLIKCQG SRLDDQRCAP
PPPPKRGPTV PDEDFFSLIL RSQAKRMDEQ RVILPSDPGP TQLNPD
//
