ID W5K1W4_ASTMX Unreviewed; 547 AA.
AC W5K1W4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Motile sperm domain containing 2 {ECO:0000313|Ensembl:ENSAMXP00000001574.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000001574.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000001574.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5K1W4; -.
DR STRING; 7994.ENSAMXP00000001574; -.
DR Ensembl; ENSAMXT00000001574.2; ENSAMXP00000001574.2; ENSAMXG00000001536.2.
DR eggNOG; KOG0439; Eukaryota.
DR eggNOG; KOG1471; Eukaryota.
DR GeneTree; ENSGT00390000016713; -.
DR HOGENOM; CLU_028924_1_0_1; -.
DR InParanoid; W5K1W4; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000001536; Expressed in mesonephros and 14 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR036273; CRAL/TRIO_N_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000535; MSP_dom.
DR InterPro; IPR008962; PapD-like_sf.
DR PANTHER; PTHR46384; MOTILE SPERM DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR46384:SF1; MOTILE SPERM DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF00650; CRAL_TRIO; 1.
DR Pfam; PF00635; Motile_Sperm; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF46938; CRAL/TRIO N-terminal domain; 1.
DR SUPFAM; SSF49354; PapD-like; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS50202; MSP; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 525..545
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 125..267
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 356..473
FT /note="MSP"
FT /evidence="ECO:0000259|PROSITE:PS50202"
SQ SEQUENCE 547 AA; 62744 MW; 1CB9600C3BD9A153 CRC64;
MAHTMLLFPL YTATFVKLEP RWCPAGRDSR DKQSRDLESK IRETRQRFKE EYIQDSSDKY
DSRDVDRLQQ DDALVDGYLT WRQFVVDDAL KMIDESFQWR KEFNLNDLTE SSIPRWMFET
GAVYLHGYDK EGNKLFWFKV KLHVKDAKTI HDKKRYVAFW LERYAKREPG MPLTVVFDMS
ESGIGNIDME FVKYIISCFK VFYPKFLSKM IMYEMPWIMN AAWKIVKTWL GPEAISKLKF
VSKSDVQTFI DAEHLPPHMG GTDQFQYSYP PLPDDEFKSP INENGPIVSE DESEVKDTES
ECKESLESSF NAEQALRPKK VNFVEDGGRV DDVDRSDGSS RLRGVRKPQT TFKGTLLHVS
PAEELSFGSK DSEKKCLIVL NNVAKNQVAF KVRTTAPEKY RVKPSSSSCE AGASVDIVVS
LHGGFQASPQ DRFLVMAAEM EPGAGAGTPE LTQFWKDVPK PKIMEHRLRC HVLESPKSIL
SNASDSPLNT PTGDTQDLQT ALMRLVVSNS RLEQKLDSCM WLQKVLLVLV SVLMAFSFST
FYWLWTS
//
