ID W5K366_ASTMX Unreviewed; 639 AA.
AC W5K366;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=TIAM Rac1 associated GEF 1b {ECO:0000313|Ensembl:ENSAMXP00000002027.2};
GN Name=TIAM1 {ECO:0000313|Ensembl:ENSAMXP00000002027.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000002027.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000002027.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5K366; -.
DR STRING; 7994.ENSAMXP00000002027; -.
DR Ensembl; ENSAMXT00000002027.2; ENSAMXP00000002027.2; ENSAMXG00000001973.2.
DR eggNOG; KOG3519; Eukaryota.
DR GeneTree; ENSGT00940000156294; -.
DR HOGENOM; CLU_000494_3_0_1; -.
DR InParanoid; W5K366; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000001973; Expressed in brain and 6 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd01255; PH2_Tiam1_2; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR043537; Tiam1/Tiam2/Sif.
DR PANTHER; PTHR46001:SF4; T-LYMPHOMA INVASION AND METASTASIS-INDUCING PROTEIN 1 ISOFORM X1; 1.
DR PANTHER; PTHR46001; TIAM (MAMMALIAN TUMOR INVASION AND METASTASIS FACTOR) HOMOLOG; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 70..264
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 39..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 495..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 526..639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 535..552
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 578..593
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 639 AA; 72052 MW; 4056F1E5534129C7 CRC64;
MSVLKRNRSR KRSSESIYSI LHLSTEQVTA FCRSLHEMNP SSDAVSPSSG PESSSAGVNT
APRQLSHADK LRKVIWELVE TERTYVKDLN CLIGRYLTPL QKESFLTQDE LDVLFGNLPE
MVEFQVEFLR TLEDGARLVP DLEKLERVEQ FKKILFSLGG SFLYYADRFK IYSAFCASHT
KVPKVLVKAK TDPAFKAFLD ERNPKQQHSS TLESYLIKPI QRVLKYPLLL RELYTLTDPD
SEEHYHLDVA MKAMNKVASH INEMQKLHEE FGAVFDQLIS EQTGEKKEVA DLSMGDLLLN
TSVTWLNPPS SLGKWKKEPQ LATFVFKTAV VFVCKDFSKQ KKKIGGSHRA SISGEERDPF
RFRHMISTSA LQVRALSGAD GDSATVCEII HIKSESEGRP ERVFHLCCSS PESKKDFLRT
VHSILRDKQR RQLLKTESLP PSQQYVPFGG KRLCALKGAR PAMNRAASAP TRTLGRRKLV
RNRFTIDTDI VFDADADADP DSPDSQHALQ PGDTDRWVEE QFDLQRYEEQ EQVKETDILS
DEEDDEEEEE DLSRSALSPA TPDDVEGQIS ALSLGEDEQA ESDSKDSKSQ HAMRLSHLGK
QCAVSVASVD DQPPPGDEVV WVRRDVGSPD SDTQNTPES
//
