ID W5K8M4_ASTMX Unreviewed; 588 AA.
AC W5K8M4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Switching B cell complex subunit SWAP70 {ECO:0000313|Ensembl:ENSAMXP00000003935.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000003935.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000003935.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5K8M4; -.
DR STRING; 7994.ENSAMXP00000003935; -.
DR Ensembl; ENSAMXT00000003935.2; ENSAMXP00000003935.2; ENSAMXG00000003854.2.
DR eggNOG; ENOG502QSXX; Eukaryota.
DR GeneTree; ENSGT00950000183017; -.
DR HOGENOM; CLU_029358_1_0_1; -.
DR InParanoid; W5K8M4; -.
DR OrthoDB; 5354765at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000003854; Expressed in bone element and 14 other cell types or tissues.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0060028; P:convergent extension involved in axis elongation; IEA:Ensembl.
DR GO; GO:0060027; P:convergent extension involved in gastrulation; IEA:Ensembl.
DR GO; GO:0048714; P:positive regulation of oligodendrocyte differentiation; IEA:Ensembl.
DR GO; GO:0007096; P:regulation of exit from mitosis; IEA:Ensembl.
DR CDD; cd13273; PH_SWAP-70; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR14383; SWAP-70 RECOMBINASE; 1.
DR PANTHER; PTHR14383:SF6; SWITCH-ASSOCIATED PROTEIN 70; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 6..41
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 209..305
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 314..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 588 AA; 69387 MW; 58253AC54DD44C59 CRC64;
MGLRDELLKS IWHAFTALDV DKSGKVSKSQ LKVLSHNLCT VMKIPHDPVA LEEHFKDDDE
GPVSTQGYMP YLNRFILDKV QDNFDRVDFN RMCWTLCARK NLNRNHLLIS DEDAFKIWCI
FNFLSEDRYP LVIVAEEIEY FLRKLTEAMG GSWIEEKFED YKTQLGSKQQ CLTAWELIEL
VGMGHFSKGM DRQTLSMGIN EVFQELILDV LKQGYMMKKG HKRKNWTERW FLLRPSSISY
YVSEDLTEKK GDIMLDGNCC VESLPDKEGK KCLFYVKCSD KSFEISASDK KKKQEWIQAI
QTCISLLKVG RPAPHREARH KRRELRQKQQ AEQEQLELRM RELQTANENK QRELEAMRKK
LEEAATNAAD EERRRLQTQN ELEGLYRAEM EKEKMVRLQM EEKVAQKSSE LEQYLQRVRE
LEDMYHRLEE ALEEEREARQ DEETVRKLQA RLLEEEAEKR TELEQIHLRQ QQAISQTQAE
KEELERERLA KEDALQAAMQ QLQQLEFERQ GALEQYEEVM KKLEDAANNT KSWKDKVAQH
EGLIRLIQPG SKGPQKITNW GPAAFTEAEL SLRQKDWQER KNRPTQTQ
//
