ID W5KB54_ASTMX Unreviewed; 790 AA.
AC W5KB54;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633};
GN Name=ITGB8 {ECO:0000313|Ensembl:ENSAMXP00000004815.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000004815.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000004815.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU000633}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the integrin beta chain family.
CC {ECO:0000256|ARBA:ARBA00007449, ECO:0000256|RuleBase:RU000633}.
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DR AlphaFoldDB; W5KB54; -.
DR STRING; 7994.ENSAMXP00000004815; -.
DR Ensembl; ENSAMXT00000004815.2; ENSAMXP00000004815.2; ENSAMXG00000004704.2.
DR eggNOG; KOG1226; Eukaryota.
DR GeneTree; ENSGT01090000259987; -.
DR HOGENOM; CLU_011772_3_1_1; -.
DR InParanoid; W5KB54; -.
DR OrthoDB; 5475862at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000004704; Expressed in brain and 10 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 4.10.1240.30; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR033760; Integrin_beta_N.
DR InterPro; IPR015812; Integrin_bsu.
DR InterPro; IPR012896; Integrin_bsu_tail.
DR InterPro; IPR036349; Integrin_bsu_tail_dom_sf.
DR InterPro; IPR002369; Integrin_bsu_VWA.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10082; INTEGRIN BETA SUBUNIT; 1.
DR PANTHER; PTHR10082:SF9; INTEGRIN BETA-8; 1.
DR Pfam; PF07974; EGF_2; 2.
DR Pfam; PF00362; Integrin_beta; 1.
DR Pfam; PF17205; PSI_integrin; 1.
DR PIRSF; PIRSF002512; Integrin_B; 1.
DR PRINTS; PR01186; INTEGRINB.
DR SMART; SM00187; INB; 1.
DR SMART; SM01242; Integrin_B_tail; 1.
DR SMART; SM00423; PSI; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF69687; Integrin beta tail domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS00243; INTEGRIN_BETA; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|RuleBase:RU000633};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR002512-1};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU000633};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000633};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..790
FT /note="Integrin beta"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017301053"
FT TRANSMEM 703..725
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 559..570
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS00022"
FT DISULFID 39..465
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 47..57
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 50..86
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 60..75
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 201..208
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 256..297
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 400..411
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 431..666
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 463..467
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 513..518
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 515..548
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 520..533
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 554..559
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 561..570
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 572..579
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 593..598
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 595..643
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 600..610
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 620..629
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 626..697
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 647..674
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
SQ SEQUENCE 790 AA; 87048 MW; 167A61685E24D443 CRC64;
MTSWPREERN ITLRSALVFI ILIITLFAVA SCQLAEKRCA SPLVSSCEEC LSRGPECAWC
FQKSFMDGAH VGERCGSAAR LLLKGCGEEF VENPSVKVEN TTLSSSQVTP RDISIQLRPG
SEASFIVEVK QLERYPVDLY YLVDVSASMQ DNLDRLKTVG VTLSHRMKEH SSDFRVGFGS
FVDKPVSPYI DVNPSKISNP CSDYDVHCRP AHGFIHVLPV TENMTDFKQV IQQQRISGNM
DTPEGGFDAM LQAAVCQKDI GWRPEAKHLL LVMTDQPSHL ALDSKLAGIV VPHDGRCHLV
DNMYSQSANM EHPTIGQLAE KLLENNIYSI FAVDQMQYKW YEDVVDFLPG TYLGKLLPKA
SNLTNLVVDA YKKLLSEVGV EVGVEDSEAH RFWVRVSAIC PNGSTETNGR CSNVQPKQTV
FFNITVGMRS CPAEGLRSGQ EVLLMVRPVG FNESVTVRVQ QACGCSCGEA GPYHEEPEPS
SCMSGGGPAA ERGLMDGCRE ERSGLVCSGR GICSCGGCVC DQSSLGTIYG QFCEKDDFSC
AYEGGLVCGG HGQCVSGECL CQPGWSGESC GCPMSSESCL SRDGSVCSGQ GKCVCGKCVC
DDPRHSGAFC EKCPTCSNSC QSHWSCVSCH VSKGFGRDEA QQCNKSCTSL VAYVDDITEL
VRGKYCLYHS REQCFFRFHM ELETHGPQLH ISRHAECVLS QRYFKTFLSI FLLTLVLGLG
ILAVIRQLLR NKSWTLGEES SEQFDDSNKS PSYAPTTSEK TITYRRDHLH EHPVEMHVHV
PKMPLSDIWP
//
