ID W5KC14_ASTMX Unreviewed; 751 AA.
AC W5KC14;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Rho guanine nucleotide exchange factor 4-like {ECO:0000313|Ensembl:ENSAMXP00000005125.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000005125.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000005125.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5KC14; -.
DR Ensembl; ENSAMXT00000005125.2; ENSAMXP00000005125.2; ENSAMXG00000044035.1.
DR eggNOG; KOG3519; Eukaryota.
DR GeneTree; ENSGT00940000160622; -.
DR HOGENOM; CLU_1093956_0_0_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000044035; Expressed in zone of skin and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01224; PH_Collybistin_ASEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11973; SH3_ASEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR47544; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR PANTHER; PTHR47544:SF1; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 236..295
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 331..515
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 546..653
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 751 AA; 85265 MW; 2FFCB1A66A379753 CRC64;
MPVCDSVCVC VCVVCVCETE RGLIVCLGFR GCARERVCER ERERASQSES EREVRGRDGA
QCRTLAPLQG LTDALTYSHT LTHAQVRTRR RYRALLIWTL APAEEKKTHP SPLGRRWLNA
AQQRVPGEVG IPLAGGIRGG VWGQYPSPSS DQDCSPALAL SMKTVRGVMS HYWSLESLHS
TNALVITDGS QDKSGLGDEV GSEDDLYNEF RSSANRFGHP GGGGGEQLAI NELISDGSVC
AEALWDHVTM DDQELGFKAG DVIEVVDATN KEWWWGRVLD SEGWFPASFV RLRVNQDEPM
EDYLAQLEGA PEGGAGGCRS LGPGLPCKEQ MRANVINEIM STERDYIKHL KDICEGYIKQ
CRKRTDMFNE EQLRTIFGNI DELYRFQKKF LKNLEKKFNK EQPHLSEIGS CFLENQTDFQ
IYSEYCNNHP NACVQLSKLM KIKKYVFFFE ACRLLQKMID ISLDGFLLTP VQKICKYPLQ
LAELLKYTNP QHRDYKDVEA ALNAMKNVAR LINERKRRLE NIDKIAQWQS SIEDWEGEDI
LSRSSDLIFS GDLTKISQPQ AKGQQRIFFL FDHQLVFCKK DLLRRDILYY KGRLDMDEME
VVDVEDGKDK DLNVSVKNAL KLTSPGRDEV HLLCAKKPEL KQRWIRAFRD EREQVQHDLE
TGFSITEVQK KQAMLNASKS HPAGKPKAVT RPYYDLLLRQ KHPALPAALP AALPPALPAA
LPPQQVIMLA QPKRKSSNFW HNIGRLTPFK K
//
