ID W5KFC0_ASTMX Unreviewed; 1444 AA.
AC W5KFC0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=HFM1 {ECO:0000313|Ensembl:ENSAMXP00000006281.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000006281.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000006281.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
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DR STRING; 7994.ENSAMXP00000006281; -.
DR Ensembl; ENSAMXT00000006281.2; ENSAMXP00000006281.2; ENSAMXG00000006108.2.
DR eggNOG; KOG0952; Eukaryota.
DR GeneTree; ENSGT00550000074822; -.
DR HOGENOM; CLU_000335_0_0_1; -.
DR InParanoid; W5KFC0; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000006108; Expressed in testis and 2 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR CDD; cd18023; DEXHc_HFM1; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47835; HFM1, ATP DEPENDENT DNA HELICASE HOMOLOG; 1.
DR PANTHER; PTHR47835:SF2; SEC63 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF02889; Sec63; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00973; Sec63; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 251..438
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 479..664
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1083..1113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1411..1430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1083..1108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1444 AA; 162475 MW; 5F82CE849551D857 CRC64;
MAECEDFTLP LDSLFFVKPV VHKVNPLCQE QNVWQLDAPP SVSEIPATQA IQKEAECMSS
VGCSQKIRKF LPPFQRPFVS AGVQDQIQAD ETGSHEMLRM QTSQTPSARK CSNRAFPGTQ
EFDITVKTRP CHPTATPLFK TRLFKPPMRM DLKSFSISSQ TNSSVDDHSL SGVAMVTEHP
PAAHAIATCS PFLDPGQIEE CNSPQQKHDS GVKKAHVLPL TPKPIHIQAA KFRGVFKEFP
YFNYVQSKAL DDILYTSKNF VACAPTGSGK TVLFELAIIR LLMETTEPWH NVKAVYMAPI
KALCSQQYEN WKLKFGPLGL NCKELTGDTE IEDVFEIQDA HLIMTTPEKW DSMTRKWKNN
CLLQSVQLFL IDEVHVVKDS TRGPTLEVVV SRMKTIHSYT VAESPDASTR MRFVAVSATI
PNICDIADWL SNDQGPATCL EMDESHRPVK LRKVVLGFPF GNSQNEFKFD LSLNYKMASV
IQTYSDQKPT LVFCSTRKGV QQSATVLAKD ARFIMSIDHR QRLMKYASSI LDAKLRDLIM
CGVGYHHAGV SLSDRKVVED AFTAGDLPVL FTTSTLAMGV NLPAHLVVIK STMHYAGGSC
EEYSEADMLQ MIGRAGRPQF DTSATAVIMT RIQTREKYLQ FISGSETIES SLHTNLVEHL
NAEIVLHTIS DVNMALDWIR STFLYIRALK NPTHYGFSSE LDKCGIETKL QELCLKNLNS
LASYQLITMD EDINIKPTES GKLMARYCVA FDTMKQFSKL TGTENLAELI EMMSKGKEFS
DVQLRVNEKR TLNTLNIDKN RVTIRYPMEG KIKSKDMKVN CLIQAQLGNL PIQEFGLTQD
TGKIFRSGVR ISKCLAEFLS HHSKQNFSAQ LNSLILAKCF RAKLWEDSPY VSKQLDKIGL
SLATAMVNAG LTSFSKIEAT NPRELELIVN RHPPFGNQIK EAVSKLPKYE IRLEQLPKYS
VSTAEILVTV NLKNFEELLT KRTAPDHHYV TLIIGDCDNN VVFQQKIQDT VLLKSGSWSR
KIEVTRTSQE DKISINLISS EYVGLDIQQT FTAFYYGAKT FRAESCGKET PVYKLQKIPE
TSQRATSSAL KSNMAPPRAQ STVQRAPTKT EPGKRECNHF CKNKDLCGHD CCKVGIQLVM
KRPQNPENSF SSYLRDLKTR NEKLLETPVK RLKMRMNAEA ENISMSQFSF SRRETMPAHT
RFEESQDYPP SVSHSMEPQQ GFAISAEASF NEDFKDFHHE TEGTVEEQMF QTDANNTFQN
AYTSRIALER QMSRIPAHKS RDHTTSSCLD HSTDNISAFD GLNVTFDLAI DDWDDFDDDN
LVLASDVSYS TEKQGGQCVQ STADCWTSAP SGCSEPRHGL LRPNQITRVG PTTTVQETQR
EIPEISAIKH PSLNLNETET LPRGRLDFFS KRDPAQDTQK GFGRDQKEEN KEADMFVSIF
DGIF
//