ID W5KFM5_ASTMX Unreviewed; 622 AA.
AC W5KFM5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=NACHT domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000006386.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000006386.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5KFM5; -.
DR Ensembl; ENSAMXT00000006386.2; ENSAMXP00000006386.2; ENSAMXG00000006228.2.
DR GeneTree; ENSGT01100000263547; -.
DR HOGENOM; CLU_002274_3_2_1; -.
DR InParanoid; W5KFM5; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000006228; Expressed in intestine and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR Pfam; PF13516; LRR_6; 4.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00367; LRR_CC; 3.
DR SMART; SM00368; LRR_RI; 5.
DR SUPFAM; SSF52047; RNI-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 21..114
FT /note="NACHT"
FT /evidence="ECO:0000259|Pfam:PF05729"
FT DOMAIN 198..256
FT /note="NOD2 winged helix"
FT /evidence="ECO:0000259|Pfam:PF17779"
FT DOMAIN 258..379
FT /note="NACHT LRR and PYD"
FT /evidence="ECO:0000259|Pfam:PF17776"
SQ SEQUENCE 622 AA; 70607 MW; F444B2610139CC88 CRC64;
MELLHHSFHE LNQLQSVDCD THKILFIFDG LDECRLPLNF LINELLCDER HKASVDVLLT
NLIMGNLLQS ALIWITSRPA AVNQIPPEYV ERVTEVRGFS DHQKEEYFRN RIRNQFLANN
IIKHVKSSRS LYIMCHIPVF CWIAATVLKR LLGTAEAEAV PKTLTQMFTH FLIFQIKHRD
QKYQGKCDPD PHKTKESILA LGKLAFQQLD KGNLIFYEED LKECGIDVSD MSVLLGVCTQ
IFREEFWLHL SKVYSFVHLS VQEFLAALYA YLTKQLTTDL SDISKQSTMS DFLKSAVDKA
LQSENGHLDL FLRFLLGLSL ESNQTLLRGL LTQAGRNSHN TQETVQYIKE KIRENPSPEK
SINLFHCLNE LNDQSLLEEV LEYVIRRDHM CLSRVSLSPA QWSALVFVLL NSDDVREEFN
LRKYDRSEEC LLRLLPVVKA SRRAVLCNCN LTEKCCTPLA SVLSSKASNL RELNLTNNDR
LQDSGVKLLS AGLKSSHCKL EILKLSDCDL TEESCAALAP ALSSKSSCLK ELSLSFNELL
QDRGVNLLCT GLKNRHCKLE ILGLSNCSIT DKGFVALASA LKANPSHLRE LNLNRNKPGE
SGVKQLSDLL EDPQCKLEKL FI
//
