ID W5KFX2_ASTMX Unreviewed; 1029 AA.
AC W5KFX2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Contactin-5 {ECO:0000256|ARBA:ARBA00044127};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000006483.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000006483.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. Contactin
CC family. {ECO:0000256|ARBA:ARBA00009812}.
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DR AlphaFoldDB; W5KFX2; -.
DR STRING; 7994.ENSAMXP00000006483; -.
DR Ensembl; ENSAMXT00000006483.2; ENSAMXP00000006483.2; ENSAMXG00000005969.2.
DR eggNOG; KOG3513; Eukaryota.
DR GeneTree; ENSGT00940000158183; -.
DR HOGENOM; CLU_005756_0_0_1; -.
DR InParanoid; W5KFX2; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000005969; Expressed in brain and 2 other cell types or tissues.
DR CDD; cd00063; FN3; 4.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR44170:SF17; CONTACTIN-5; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF13927; Ig_3; 3.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 6.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor {ECO:0000256|ARBA:ARBA00022622};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00022622};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 55..140
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 163..238
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 256..341
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 411..498
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 501..595
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 602..700
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 705..802
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 807..901
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 902..996
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 686..712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1029 AA; 112833 MW; 489CC9BCE04ACB3B CRC64;
MKPDSSSSSL LTPRSRPRQD HGSFAQDWPP FSRQRLSALS SQEDYRSEES EEYGPVFIQE
PDDAIFSLDS DDKKVMMSCE ARGNPAPTYS WLINGTDVDV EADFRYSLID GNLIINNASE
AIDFGKYQCR AENSVGTVLS REALLQFAYL GVFSTRARGG VSVREGQGVV LMCTPPPHSP
EIIYSWVFNE FPSFVAEDSR RFISQETGNL YISKVQPSDV GSYICLVKNT VTNARVLSPP
TPLTLKTDGV MGEYEPKIEV HFPPTVLAAK GVTVRLECFA LGNPVPTITW RKINGNIPKK
ARLRKSQAVL EIPNIQLEDS GSYECKAENS RGGTAFRGHL QVYTMPQWTS MINDSQLDKP
LTPQNRVEML NGELIIHRVQ QADSGMYQCV AENKYGAIYS SAELKILASA PMFNTNTVTI
IATMGKDVSL ECRPRASPKP RITWNKGDRR VQASRRIMLL RNNTLRIINS SRADEGSYVC
QADNQFGSAE MTTTLLVKEA MKVELSPKRV EVTVGESVVL SCKATHDPSL DVNFLWLLNN
QPLNAQQGGG HFEYIRTQSS TADLMIRSIL LKHAGKYGCR VQTTADTVLA EAELLVRGPP
GPPGVVIVEE ITDTTATLSW SHGVDNHSPI TTYNLQARSP FSLGWQTVKT DPEPVTGDME
SAMAIELNPW VEYEFRVVAT NSIGTGDPSA PSRAVRTKEA VPSVAPTNVS GGNGRRHELV
VSWEPVSEEF QNGEGFGYIV AFRANGTRGW KEKMVTSADS TTYKYRDETF PPLTPFEVKV
GVYNNKGDGP FSKVVTVFSA EGEPREAPTE VKASAMSSSE IKVIWKAPNP GPGRPQGYEV
SYWKDMEQEE SGKKKRTVGN ETAMLLSGLD GNTVYLITVK GFNSIGQGPP SAAIRVNTKK
NPPSLPPGNV MWIQEGNNVS LSWDPVKAME NESDVIGYKV LLRQEGRGHS QVMRTPNSAA
VLVLPEGGTY IIVVRAVSEG GEGAASSEIR VLTSSGVRAK SGQLSVHTLP SNLVWTPLLL
VLMVPSAPW
//
