ID W5KG52_ASTMX Unreviewed; 761 AA.
AC W5KG52;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=NACHT domain-containing protein {ECO:0000259|PROSITE:PS50837};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000006564.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000006564.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5KG52; -.
DR Ensembl; ENSAMXT00000006564.2; ENSAMXP00000006564.2; ENSAMXG00000006396.2.
DR eggNOG; ENOG502SBIG; Eukaryota.
DR GeneTree; ENSGT01100000263547; -.
DR HOGENOM; CLU_002274_3_0_1; -.
DR InParanoid; W5KG52; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000006396; Expressed in mesonephros and 8 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029495; NACHT-assoc.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR Pfam; PF14484; FISNA; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM01288; FISNA; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 254..388
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 52..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..76
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 761 AA; 86176 MW; 539A6388D9E1D4E4 CRC64;
MEDSHTLQDE DASTGHREEP GSPVPLSCAS MRSNSSMNRP IIFQGKNPSI FRPAVHQNRP
VPLPSSHVSI KSHQSMDPPI TIKDKPLPSE SRSVPSASSC VSLKSDKSIE PPISFPTNPK
PSGQEMAELK PVGKPKSPNI VKTGGAVERS ISLSTRDFLK LLLCEDESYK KYKSSLKDRF
QRLSDQLPNS GQSTLLDDIY TDLYITEGDS GEVNTEHEVR QIEMAARTQQ LMGDKSIKCN
DIFKPLPEQD KLIRTVLTKG VAGIGKTVSV QKFIVDWAEG KANQDVRFIF PLPFRELNLI
NDQSFSLEGL VHRFIPQLEK MPFIDIAEHD IVFIFDGLDE CRSVMDFKND KIINDVTDRT
TVDMLLSNLI KGNLLPKAKI WITSRPAASS QIPVEFVSQV TEIRGFNDPQ KVEYFQKRIR
DQSLAKKTIA HLKSSRSLYI MCHIPVFCWI SATVLERMLR ETEDAAIPKT LTQMYTHFLI
IQTSIQKEKY SPSEDKEIDK EMILKLGHLA FRQLIKGNLI FYEEDLKDCA IDVEDAVVYS
GVCTQIFREE FELHLRREKV FCFVHLSIQE HLAALYVYIS FSEGEQTVLN LWNPTKIAAA
FPCLSIYDLH QSAVDKALKS TNGQFDLFLR FLLGLSLENN LALLQVLLPR VAAGCTTSVE
KTIDYIKIRL RMTLPPEKYI NLFHCLNELN DSSLQDEIQT LLGSGRLSKT KLSPAQWSAL
VFVLLNSDRE LSVFDLRKYS LSNADECLYR MLPCCRSLKN S
//
