ID W5KGK4_ASTMX Unreviewed; 426 AA.
AC W5KGK4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Ankyrin repeat and MYND domain containing 2 {ECO:0000313|Ensembl:ENSAMXP00000006716.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000006716.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000006716.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000256|ARBA:ARBA00004138}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; W5KGK4; -.
DR STRING; 7994.ENSAMXP00000006716; -.
DR Ensembl; ENSAMXT00000006716.2; ENSAMXP00000006716.2; ENSAMXG00000006550.2.
DR eggNOG; KOG1710; Eukaryota.
DR GeneTree; ENSGT00390000016820; -.
DR HOGENOM; CLU_048951_0_0_1; -.
DR InParanoid; W5KGK4; -.
DR OrthoDB; 2882203at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000006550; Expressed in testis and 14 other cell types or tissues.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 6.10.140.2220; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR002893; Znf_MYND.
DR PANTHER; PTHR24150; ANKYRIN REPEAT AND MYND DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR24150:SF8; ANKYRIN REPEAT AND MYND DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01753; zf-MYND; 1.
DR SMART; SM00248; ANK; 3.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF144232; HIT/MYND zinc finger-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS01360; ZF_MYND_1; 1.
DR PROSITE; PS50865; ZF_MYND_2; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00134}.
FT REPEAT 45..77
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 79..111
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 320..357
FT /note="MYND-type"
FT /evidence="ECO:0000259|PROSITE:PS50865"
FT REGION 368..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..390
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..426
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 426 AA; 47525 MW; 1A84EB0E24E67DBE CRC64;
MSAPVKGDLS DTEKELFVVI AAGNVQEASR LLGSKDVRVN CLDEYGMTPL MHAAYKGKAD
MCKLLLQHGA DVNCNQHEHG YTALMFAGLS GKTDITWMML DAGAETDVVN SVGRTAAQMA
AFVGQHDCVT VINNFFSRKR LDYYTKAQGL ETEPKLPPKL AGPLHKIIMS TNLNPVKMVM
LVKENPLLVD VEALEKCRKV MELICEKCVK QQDMNEVLAM KMHYISCVLQ KCSSFLKDRE
DKLDGLIKSL LKGRDSDGFP VFQEKFIREC IRKFPYCDAT LLQQLVRSIA PVEMGNDPTA
LSVLTQAITG QVGFMDAEFC TTCGEKGAEK RCSICKMVIY CNQDCQKLHW FTHKKICKTL
QETRQKHEAE SAKRLEKQAK EAEEQKALEE TTNTMENLSV EKSEVASTSD IQIETASSEP
IPVNAE
//
