ID W5KN18_ASTMX Unreviewed; 666 AA.
AC W5KN18;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=SH3 domain-binding protein 1 {ECO:0000313|Ensembl:ENSAMXP00000008980.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000008980.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000008980.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5KN18; -.
DR STRING; 7994.ENSAMXP00000008980; -.
DR Ensembl; ENSAMXT00000008980.2; ENSAMXP00000008980.2; ENSAMXG00000008736.2.
DR eggNOG; KOG4270; Eukaryota.
DR GeneTree; ENSGT00940000158369; -.
DR HOGENOM; CLU_013806_2_1_1; -.
DR InParanoid; W5KN18; -.
DR OrthoDB; 7959at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000008736; Expressed in mesonephros and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR047165; RHG17/44/SH3BP1-like.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR14130; 3BP-1 RELATED RHOGAP; 1.
DR PANTHER; PTHR14130:SF12; BARGIN-RELATED; 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00721; BAR; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 13..238
FT /note="BAR"
FT /evidence="ECO:0000259|PROSITE:PS51021"
FT DOMAIN 250..442
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 463..666
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..533
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..657
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 666 AA; 73834 MW; B36649BEB4EE2E62 CRC64;
MLKPFNILKQ FGGVGKSQDA TDLLSEDLVL VEQRVEPAKK AAQVIHKKLT SCLQSQQGLD
TEKRMKKLPL MMLSVSMAES FKDFDAESSI RKVLEMCCFM QNFLAQTLAD FEMKLEKDVL
EPLNKLSEDD LPEILKNKKQ FAKFTTDWNN ARTKSQTSTG PQAKQDGLRE EVEEAWRKLE
AIKDQYSADL YHFATKEDEY ANYFIRLLEL QAEYHRVSHE FLAKNITEIK ESQSQTECQV
GVSAGKVYGT SLCSHLESCG QEIALPIREC VNMLLRTGLR EEGLFRLAAA ASVVKKLKSS
LDSGTVDHSE FYTDPHAVAG ALKSYLRELP EPLMTSELYN DWFKAAGEKE LEDKLEQLRA
ILKKLPQENY NNLRYLVQFL ACLSEHQAVN RMTPSNIAIV LGPNLLWPRT EGETSLLDMA
SASSVQVVQV IEPLIQYSKS LFPEEVDFEI PELPELSPSI SQRSLSDSVF PSSPPASSHA
SVSKTDSITS FDDIKTSPVN HGATVWESNN TIPVSRNSQA QKREQTQPQP QKQAPPQTKE
PRPAEGCSSP EPTLKITTPF KPRRSFIQAR PNKEAVSISF IKPKAPGASL SQAGIPPTPV
PRSFPSALPT VPEAQAQPAA KAQAPPAPPA SLPEGGPQRK APGRRPNVPP PLPPQQLPKQ
LSSSAQ
//
