ID W5KNQ1_ASTMX Unreviewed; 526 AA.
AC W5KNQ1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Laminin, alpha 3 {ECO:0008006|Google:ProtNLM};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000009213.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000009213.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR AlphaFoldDB; W5KNQ1; -.
DR Ensembl; ENSAMXT00000009213.2; ENSAMXP00000009213.2; ENSAMXG00000030561.1.
DR eggNOG; KOG1836; Eukaryota.
DR GeneTree; ENSGT00940000155638; -.
DR HOGENOM; CLU_078124_0_0_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000030561; Expressed in olfactory epithelium and 12 other cell types or tissues.
DR CDD; cd00055; EGF_Lam; 4.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574:SF285; LAMININ SUBUNIT ALPHA-3; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00053; Laminin_EGF; 4.
DR Pfam; PF00055; Laminin_N; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00180; EGF_Lam; 4.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR PROSITE; PS01248; EGF_LAM_1; 1.
DR PROSITE; PS50027; EGF_LAM_2; 2.
DR PROSITE; PS51117; LAMININ_NTER; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..526
FT /note="Laminin, alpha 3"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017421719"
FT DOMAIN 39..292
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 419..462
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 476..520
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DISULFID 438..447
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 476..488
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 496..505
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 526 AA; 58610 MW; EF08442BC98BAC15 CRC64;
MIMAWSRRPP HSTGLLLPLL LCCSLFHQVS TQVSVNEISG FSLSPPYFNL AEGSSVSATA
TCGEDHLSRP RSDLYCKLVG GPAIGVPSQT IQGQFCDYCN ANDPDKAHPV TNAIDGTERW
WQSPPLSRGL NYNEVNVTLD LGQLFHVAYV IVKFANSPRP DLWVLERSVD NGRTFTPWQY
FAHLKRDCIE RFGKQPNARV RQDNDQMCTT EYSKIVPLEN GEIVVSLVNG RPGSKNFTYS
PVLQEFTKAT NIRLHFLRTN TLLGHLISKA QRDPTVTRRY YYSIKDISVG GRCVCHGHAQ
VCGVRVPGRL LCECEHNTCG ESCDRCCPGF HQKQWRPATA NSPNECEPCQ CHSHSAECRY
DAEVERRGAS LNIHGRYDGG GVCINCRHNT AGVNCELCAE GYYRPYGVPR ESPTGCISCR
CDPRTTMGCE MGTGRCLCKP QYSGSNCERC ASGYYGYPQC IRTFNIWMYV CCSAACDCEQ
RGSVPEVCTA SGRCLCRPGV TGERCDRCLS GYLYFPNCRV HLYSPI
//
