ID W5KRH0_ASTMX Unreviewed; 979 AA.
AC W5KRH0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=B30.2/SPRY domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000010182.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000010182.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5KRH0; -.
DR Ensembl; ENSAMXT00000010182.2; ENSAMXP00000010182.2; ENSAMXG00000009913.2.
DR GeneTree; ENSGT01100000263529; -.
DR HOGENOM; CLU_002274_0_1_1; -.
DR InParanoid; W5KRH0; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000009913; Expressed in intestine and 5 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR CDD; cd08321; Pyrin_ASC-like; 1.
DR CDD; cd16040; SPRY_PRY_SNTX; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029495; NACHT-assoc.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR Pfam; PF14484; FISNA; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF02758; PYRIN; 1.
DR Pfam; PF00622; SPRY; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM01288; FISNA; 1.
DR SMART; SM00368; LRR_RI; 3.
DR SMART; SM00589; PRY; 1.
DR SMART; SM01289; PYRIN; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 1..89
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 173..308
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT DOMAIN 785..979
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
SQ SEQUENCE 979 AA; 112253 MW; F975F86A1C1796D1 CRC64;
MSKIKELLLK TFKNLKTDEL KTFQWHLRNG VDDFSPIPQC DLENADRPAT VDTLVSTYGP
SDAVEATLAA LKKINQNQLA EELKAENNLK EKEKRYFVLK FAQRPDRASL EEGHSLLQDT
YTDLCVTKGC TGGVNTEHEF QQIKESYHRS KDQSPVKFSD LFQVSSNQTA PGAKVLTFGT
AGVGKTASVE KFILDWAEEK SNQDIDFILF LPFCELNVIK DKEFNLLGLV SYFHRDFNGA
DVQEMLRENG RMIFIFDGLD ESQIHLEFNQ EKISEITEET TLDRLLVNLI KGELLPSALV
WITSRPAAAD KIPYKYFHEV TEICGFNNLQ KEEYVKKIIR DQDKACRIIT HIRSRKSLHI
LCHIPIFCNI SATVLLEMLD APATLTEIYT RFLVYQTKQK NDKYSLKTNR DSTVALVERD
TTKVSDIKKL GKLAFRLLNK GQLTFYKKDL DKCDIDVDGA LVHSGVCTRI FSKDEEIFSF
LHLSFQEFLA AVFVFLVFVS DEQDPCRQTL KEMKWKIKPK LADNLNTAVD KAMASKNGHL
NLFLCFLIGL HSNQKLLKFL QPELEINRES LEETKKHIKS TIDKTTSSEK ILNLFHCMSE
LKDSSLTSDI QKHLISGDIT EKELSPSQWA AQVFKLQMSD ETQDTFDLKK YSPSDNGLRR
LLPVVKITQK ALLDNCDLNK NSCKTLATVF SSTLKELDLS NNDLQDAGVK HLCEGLKSSH
CKLEVLRLSG CMITEEGCSF LELALSSNPS HLKELDLTYN HPGESGVKRL TARREDPHFR
LMTLRVEHAG EKRIEQGPRK YACKIELDPN TAHRYLHLCE GNRKVVYTEE QRAYPDHPDR
FDTFEQVLST EGLKGRCYWE TEWSDEAEIA VTYKGIDRKG DTESRFGWND KSWSLIFSND
KYSIWHNQEK IQLPDPHFRS NRVGVYLDWP AGTLSFYSVL SAGQNVKFFP LFTFHSRFTE
PLYAGFRVIN DSFLRLCDI
//
