ID W5KRJ6_ASTMX Unreviewed; 2250 AA.
AC W5KRJ6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=ATP-binding cassette, sub-family A (ABC1), member 4b {ECO:0000313|Ensembl:ENSAMXP00000010208.2};
GN Name=ABCA4 {ECO:0000313|Ensembl:ENSAMXP00000010208.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000010208.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000010208.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR STRING; 7994.ENSAMXP00000010208; -.
DR Ensembl; ENSAMXT00000010208.2; ENSAMXP00000010208.2; ENSAMXG00000009875.2.
DR eggNOG; KOG0059; Eukaryota.
DR GeneTree; ENSGT00940000155624; -.
DR HOGENOM; CLU_000604_19_0_1; -.
DR InParanoid; W5KRJ6; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000009875; Expressed in camera-type eye and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR PANTHER; PTHR19229:SF190; RETINAL-SPECIFIC PHOSPHOLIPID-TRANSPORTING ATPASE ABCA4; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 23..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 686..706
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 726..750
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 762..785
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 791..811
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 867..888
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1345..1366
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1650..1672
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1702..1719
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1731..1749
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1761..1786
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 940..1171
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1903..2135
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 1290..1311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2250 AA; 254145 MW; 48C702D59359429B CRC64;
MNTAGQVRLL LWKNWTLRKR QKIRFVVEIF WPVFLFAGLV WLRKANPLYR QHECHFPNKA
LPSAGILPWI QGIFCNANNP CFRYPTPAES PGTISNYNNS ILARFYADSQ ELLFRDTEFQ
QLGRLWQEAS TLSVFMDTMR KDPGRVAGRG LMVEDILKDD ETLTSFLLRD AGLSESVVHQ
LTKALVRVEQ FAYGVPDLNL KDIACSQALL ERFIIFPSRR GLYSVRNAMC ALTQQRLQDI
EDKLYANVDF FKLFKLVQSS EVLLTAPGSR DLLRVLMPVF QGGPSSFSQL TSIVSDLFCG
YPDGGGSRVM SFNWYEDNNY KAFLGINNSR SHESYIYDDT ATPFCNTLMQ NLESNPVTKI
VWNSVKPLVM GKILYSPDSP AVQKILKSAN TTFEELERLM NMMKVWEEVG PQLWQFFQDS
IQMNMIRDTL RNPTVMDFLD RRLEDSQFNT KHILNFLHNG CETERYGDMP SFDWRNVFNL
TDQVIRMFIQ YSECINLDKF VGHMDEDQLS HQALYLLEEN KFWAGLVFTN MYPWTTTLPK
HIKYKIRMDI DAVERTNKIK DRSLYTTPSL YIPNTITLYH TPSLYIPNTI TLYHTPSLYI
PNTITLYHTP SLYIPNTMYW DPGPRADPME DQRYIWGGFA YLQDMIEHGI LKIQTGQDWP
MGVYVQQMPY PCYVDDMFML TLNRCFPIFM VLAWIYSVSM MVKSIVLEKE MRLKETLKAM
GVTNAVIWYT WFIDSFIMMT SSTALLTIIV MIGKVLNYSN PIILFFFLLT FSTATIMQCF
LMSVFFNKAN LAAACSGIIY FTLYLPHILC FAWQDRITKN MKLGVSLLSP VAFGFGTEYL
SRYEEQGLGL QWDNIGTSPL EGDEFSFLNS IGMMLFDSVL YAVLAWYLDN VFPGQYGIGR
PFYFPLQPSY WQRPERPLSD MADPGNLFFE AEPEGLVLGV AVKDLVKVYS GSSRPAVNCL
NITFYEGQIT SFLGHNGAGK TTTLSILTGL FPPTSGTAYV NGMDIRTDMD AIRQSLGMCP
QYNILFNHLT VEEHILFYSL LKGREQKEAE QEVEDMLEDL GLPNKRDDEA QNLSGGMQRK
LSVAMAFVGG SKVVILDEPT SGVDPYSRRS IWDLLLKYRT GRTVILSTHH MDEADLLSDR
VAIISKGQLH CCGSPLFLKN CFGVGFYLTL VRRIKDLRKK EVSYQPITDR GRGYNSSHRP
STPHTTWSYL IVTVLIHHHV PEAKLIEMIG QEMTYLLPNK GFKHRSYASL FRELEETLGD
MGLSSFGISD TSLEEVLKCS TVLAAEVNGT PENGVQGNGV GKHEESDSSA GKASRQVKGF
TLVLKQFHAL LVKRLHHATR SQKDFLAQIV LPASFVLIAL IFTLIVPPFG EYPSLTLSPA
MYGQQFTFLS NERPDHPTMT RFIYTTLAEP GLGTRCMMDP TPVCNNGSSD WTDPPVSPVV
SNILLSPEWT ERNPSPSCQC SSGNKLIMLP VCPIGAGGLP PRQRTEASGD VLQDLTDRNI
SDYLVKTYPS LIKTSLKSKY WVNEQRYGGL SVGGKLPVLD VDPKDIQRVL SQVGQMMNIT
GGPRSKLALK DVGPFLRYME SEYNVKVWYN NKGWHAMVSF MNVANNAILR ANLPPHTNPA
EYGITAINHP LNLTKEQLSE VTVLTTSVDA VVAICVIFAM SFIPASFVLY LIQERVTKAK
HLQFVSGVSP LVYWVANFFW DMLNYGISTA MVVGIFVGFD KKCYTSPSNL PALVALLSLY
GWSITPMMYP MSYIFSIPST AYVSLSCVNL FIGINSSAIT FILELFENNR SLLMFNEGLK
KVLLVFPHFC LGRGLIDLAM NQAVTDVYAR FGEEHSLDPF RWDFVGKYLV FMAIEGPVYF
LLNLLIQYRF FLDHCQISVN DEDDDVAQER QRVYSGGSKN DILHIRDLSK TYVGRKRPAV
DRICVGVPAG ECFGLLGVNG AGKTTTFKML TGDTDVTSGE ASVAGYSILS NILDVHQNMG
YCPQFDAIDE LLTGREHLYL YARLRGVPER EISRVVEWGI QKLGLVEYAG RCAGTYSGGN
KRKLSTAIAM IGCPPLVLLD EPTTGMDPHS RRFLWNAIMS VIRDRRAVVL TSHSMEECEA
LCTRLAIMVN GTFKCLGTIE HLKYKFGDGY VVTMKIRAPK PGLSPDLGPA EAFMDSSFPG
CVQREKHYNT LQYEIAASSL ARVFQLVAAN KEKLSIEDYS VSQTTLDQVF VNFAKQQSGE
DDDVILHPRA AGARREMKIS PLTTTSKNTR
//
