ID W5KSK6_ASTMX Unreviewed; 1815 AA.
AC W5KSK6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Calcium channel, voltage-dependent, T type, alpha 1H subunit a {ECO:0000313|Ensembl:ENSAMXP00000010568.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000010568.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000010568.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSAMXT00000010568.2; ENSAMXP00000010568.2; ENSAMXG00000010289.2.
DR eggNOG; KOG2302; Eukaryota.
DR GeneTree; ENSGT00940000165827; -.
DR HOGENOM; CLU_000540_2_0_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000010289; Expressed in brain and 5 other cell types or tissues.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR005445; VDCC_T_a1.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF192; VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1H; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR01629; TVDCCALPHA1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 36..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 127..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 254..275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 659..677
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 697..717
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 780..802
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 858..880
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1161..1179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1199..1221
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1292..1314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1393..1417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1473..1492
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1504..1525
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1601..1622
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1692..1713
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..316
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 658..886
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1159..1427
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1473..1724
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 930..1065
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1722..1755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1420..1447
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 977..1018
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1019..1048
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1049..1063
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1815 AA; 207030 MW; 22ACDE1771384ABE CRC64;
MLVILLNCVT LGMYQPCEDV ACQSEWCIIL RAFDDCIFAF FAVEMVIKMM ALGIFGPACY
LGDTWNRLDF FIVMAGMLEY SLDGHNASLS AIRTVRVLRP LKAINRVPSM KILVTLLLDT
LPMLGNVLLL CFFVFFIFGI VGVQLWAGLL RNRCFMKENF TDIYNLSMSQ YYMDEDGEDN
PFICSSEKEN GMRRCRNVPP LMENGFNCTL NASFSHYTYS DPNSCVNWNQ YYNQCRPGDL
NPHKGAVNFD NIGYAWIAIF QVITLEGWVD IMYYVMDAHS FYNFIYFILL IIVGSFFMIN
LCLVVIATQF SETKQRVNKL MKDQRVCYQS NDSTLASYSE PGSCYEEMLR YISHLYRKVK
RRTSRLYHGW QSKRRKKINP NSSLAGVGGA GVGGANGHSR QRSRNHWAHS IHNLIQHHQH
HHCHLSNGLP SPQATTGSSE ALEMRFITPG TQFTVPSRLN AGQDLSPGIQ SVHSIFQGDF
HEAPQVCTGT TAGVSSLGRL NGGMNYPTIL PSFICSYTGR NPTAKGRDES NNGTTDVTDP
LEKLQQLTGD HSKSPFCHLL TSPYHRPVTS PMKGMVPTAL LFEVLGCPYC ARTLENMDLE
LAESECSRSE GEVVHEFSHG VEFKPSRLHH QKRLCERIHM ARYWEDFRDR MKRIVDSKYF
NRGIMIAILI NTLSMGIEHH EQPKELTDIL EISNIVFTSM FVLEMIFKLV AFGIYGYIKN
PYNIFDGIIV VISVWEIIGQ ADGGLSVLRT FRLLRVLKLV RFLPALRRQL VVLMKSMDNV
ATFCMLLMLF IFTFSILGMH LFGCKFCLKT ENGDTIPDRK NFDSLLWAIV TVFQILTQED
WNVVLYNGMA SSSPLASLYF VALMTFGNYV LFNLLVAILV EAFQAEGDAN RSDSDEEKRS
VDFEEEEKMG ELRARELKMY SLMMSANGHV ESRGNLPPPI IMRTAATPMP TPKSSLGPES
VFGLGESRRG SGVSIDPNGY DQRSLSSPRR SPCHPRSTGS NWGSRRSSWN SLSRAPSLKR
KDTSGERESL LSGEGRGSFE DDDTDENLSG RAGSTSGGSL QHPSSLEFPD LAPGPCLYPS
EEYHDCNGRA MQLPTDLPAE LNREDSANEE DLDDSFCCRL RRMLNAYKPQ WCKDHEDWSL
YMFSPENKFR VICNRIISHR LFDHVVLVFI FLNCITIALE RPNIKPHSTE RVFLSISNYV
FTVIFLAEMT VKVVALGFYS YLQSTWNILD GMLVFVSLID ILVSLASSGG NRILGILRVL
RLLRTLRPLR VISRAPGLKL VVETLITSLR PIGNIVVICW AFFIIFGILG VQLFKGKFYH
CEGLDTRNIT NKSDCLLANY KWVPRKYNFD NLGQALMSLF VLSCKDGWVN IMYDGLDAVG
VDQQPVRNHN PWMLLYFISF LLIVSFFVLN MFVGVVVENF HKCRQDQEEE EARLREEKRR
RQQEKRRRKA QKIPYYAYYS PIRLYIHTLC SNHYLDLFIT FIICINVVTM SIEHYDQPQY
LEEALKYCNY VFTIFFILEA ILKLVAFGIR RFFKDRWNQL DLAIVLLSIM GITLEEIKMN
AALPINPTII RIMRVLRIAR VLKLLKMAKG MRALLDTVMQ ALPQVGNLGL LFMLLFFIYA
ALGVELFGKL DCIKQPCEGL SRHATFENFG MAFLTLFRVS TGDNWNGIMK DTLRECIPAD
NCLSYLPLVS PLYFVTFVLM AQFVLVNVVV AVLMKHLEES NKEAKEEAEM DSDTEMDKEI
QNDEERQGTQ ENFLSPRKMS VSRMHSLPND SYMFRPVRPA SAPYPLQELE PNQGYPELGT
LFFNQTKVHN LDFRL
//
