ID W5KTA2_ASTMX Unreviewed; 634 AA.
AC W5KTA2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Fermitin family homolog 3-like {ECO:0000313|Ensembl:ENSAMXP00000010814.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000010814.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000010814.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the kindlin family.
CC {ECO:0000256|ARBA:ARBA00008052}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; W5KTA2; -.
DR Ensembl; ENSAMXT00000010814.2; ENSAMXP00000010814.2; ENSAMXG00000010529.2.
DR eggNOG; KOG3727; Eukaryota.
DR GeneTree; ENSGT00390000013444; -.
DR HOGENOM; CLU_011611_0_0_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000010529; Expressed in mesonephros and 14 other cell types or tissues.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:InterPro.
DR CDD; cd13205; FERM_C_fermitin; 1.
DR CDD; cd17185; FERM_F1_KIND3; 1.
DR CDD; cd01237; PH_fermitin; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR037843; Kindlin/fermitin.
DR InterPro; IPR040790; Kindlin_2_N.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037837; PH_Kindlin/fermitin.
DR PANTHER; PTHR16160; FERMITIN 2-RELATED; 1.
DR PANTHER; PTHR16160:SF1; FERMITIN FAMILY HOMOLOG 3; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF18124; Kindlin_2_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 334..430
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 634 AA; 73517 MW; E6C05F773B77EAF2 CRC64;
MAAWDLSVIV EDMGPEAPPL KISVTSDLHI GGVIFQVVEK INLQRDWSDH GLWWEQKQQW
LLRTSWTLEK YGIHADARLI FSPQHKPLRL GLPNGVTLRL RACFSSSVFR TVQGICRVLN
IRHPEELSLL RPVEEKKKKK DKDSAEDEYD LTNVPLTSVP TLYNGMPAHF ADSPKTEFVY
RMLSVCQPSP PPETIAKLYR PASKVDKTHI HSRWLDSSRS LMQQGIQEND KLWLRFKYYT
FHDVEPKYDA VRMTQLYEQA RWAILLEDND CTEEEMMLFG ALQYHIGKLS QTQEVGSCQG
MEDLDSALNM QKDNKFTYTW LLSTICLKHL VFVLLFRPKR LTLRDYKQYW FKFQDTSIFY
YKSFEDRYGE PIQQLNLKGC EVAPDVNLAG QKFCIRLLIP VPEGMNEVYL RCENEKQYAE
WMAACKLASK GLTLLDSSYQ SEVKNIQMFL SMQRSNSSSS TPQTDDSINT QSLVSPRYTK
KYKVKQLTPR ILEAYQNVAQ LSMTAAILKF LQMWQSLPDF GISYFMVRFK GSRKDEVLGI
ANNRLIRIDL GVGDVVKTWR YNHMRQWNVN WDIRQVAIEF DGNINIAFGC VTADCKVVHE
YIGGYIFMST RSRQPSDTLN EELFHKLTGG HEAL
//