ID W5KZ57_ASTMX Unreviewed; 1110 AA.
AC W5KZ57;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Unconventional myosin-Ie {ECO:0000313|Ensembl:ENSAMXP00000012869.2};
GN Name=MYO1E {ECO:0000313|Ensembl:ENSAMXP00000012869.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000012869.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000012869.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR AlphaFoldDB; W5KZ57; -.
DR Ensembl; ENSAMXT00000012869.2; ENSAMXP00000012869.2; ENSAMXG00000012478.2.
DR eggNOG; KOG0162; Eukaryota.
DR GeneTree; ENSGT00940000157461; -.
DR HOGENOM; CLU_000192_7_6_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000012478; Expressed in pharyngeal gill and 14 other cell types or tissues.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd01378; MYSc_Myo1; 1.
DR CDD; cd11827; SH3_MyoIe_If_like; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035507; Ie/If_SH3.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR010926; Myosin_TH1.
DR InterPro; IPR036072; MYSc_Myo1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF341; UNCONVENTIONAL MYOSIN-IE; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF06017; Myosin_TH1; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS51757; TH1; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 19..692
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 730..922
FT /note="TH1"
FT /evidence="ECO:0000259|PROSITE:PS51757"
FT DOMAIN 1053..1110
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 569..591
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 918..1055
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 931..945
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 967..1018
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 112..119
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1110 AA; 127021 MW; 114482763189A97D CRC64;
MGSRGHYRYH WQSHNVKQSG VDDMVLLTKI NEDAIVENLK KRYMDDYIFT YIGPVLISVN
PFKQMPYFGD KEVEMYQGAA QYENPPHIYA LADNMYRNMM IDRENQCVII SGESGAGKTV
AAKYIMGYIS RVSGGGPRVQ HVKDIILQSN PLLEAFGNAK TLRNNNSSRF GKYFEIQFSS
GGEPDGGKIS NFLLEKSRVV MRNPGERSFH IFYQLIEGAS GDQKSSLGIT SLDYYSYLNQ
SGSYKVDDIN DKSDFQETLH AMDVIGISRE DRTMVLQIVA GVLHLGNISF REAGNYAAVE
SEEFLAFPAF LLGIDQARLK EKLTSRKMDG RWGGKSESID VTLNVEQACF TRDALSKALH
ARVFDFLVES INKAMVKDHQ ELNIGVLDIY GFEIFQKNGF EQFCINFVNE KLQQIFIELT
LKAEQDEYVQ EGIRWTTIEY FNNKIVCDLI ESKINPPGIM SILDDVCATM HAKGEGADQT
MLQKLRMQIN NHEHFNSWNQ GFIIHHYAGK VSYDAEGFCE RNRDVLFTDL IELMQSSEIA
FIRALFPENL NADKKGRPTT AGSKIKKQAN DLVSTLMKCT PHYIRCIKPN ETKKPKDWEE
SRVKHQVEYL GLKENIRVRR AGYAYRRVFR KFLNRYAILT KESWPTWRGD EKQGVLHLLR
SVNMDQDQYQ LGRTKLFIKA PESLFLLEET RERKFDGYAR AIQKAWRQYV ARKKYVQMRE
EASDLLLNKK ERRRHSLNRN FIGDYLGMDD RPELRQFLGK REKIDFADKV TKYDRRFKGI
KRDLILSPKC VYLIGREKVK QGPEKGQIKE VLKRRVDVEK IMAVSLSTLQ DDFMILHEQE
YDSLLECVFK TEFISLLSRR FEEKTQRKLP LKFGNTLEMK LKKESWGPWS AGGSRQVQFI
QGQGDAAVLR PSNKMLQVSI GPGLPKNSRP TKKSIIGQSR SNMSRPHHHT PTRVAPGPPV
HQNGGLKHSN HAASQRNQQH QSSQRSAPAN QSRPFLPVTA NQLKDRSSRQ SAQQPNLDCL
RVPDQGAAGA HRQSTNRPAP GGGRPKPAPK PKPQVPQCKA LYAYDAQDTD ELSFNADDII
EITMEDASGW WTGRLRGKQG LFPNNYVTKI
//
