ID W5L0U6_ASTMX Unreviewed; 294 AA.
AC W5L0U6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Parvin, alpha a {ECO:0000313|Ensembl:ENSAMXP00000013458.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000013458.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000013458.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the parvin family.
CC {ECO:0000256|ARBA:ARBA00005666}.
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DR AlphaFoldDB; W5L0U6; -.
DR STRING; 7994.ENSAMXP00000013458; -.
DR Ensembl; ENSAMXT00000013458.2; ENSAMXP00000013458.2; ENSAMXG00000013084.2.
DR eggNOG; KOG3631; Eukaryota.
DR GeneTree; ENSGT00950000183194; -.
DR HOGENOM; CLU_047624_2_0_1; -.
DR InParanoid; W5L0U6; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000013084; Expressed in zone of skin and 14 other cell types or tissues.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR028433; Parvin.
DR PANTHER; PTHR12114:SF6; ALPHA-PARVIN; 1.
DR PANTHER; PTHR12114; PARVIN; 1.
DR Pfam; PF00307; CH; 2.
DR PIRSF; PIRSF039131; Parvin; 2.
DR SMART; SM00033; CH; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR PROSITE; PS50021; CH; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 42..149
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
SQ SEQUENCE 294 AA; 34061 MW; 9ED21B1571C0F0C8 CRC64;
MNAINLPLSP TPYELHPEDT MLEENEVRTM VDPNSKNDRK LQELIKVLID WINDVLVGER
IIVKDLAEDL YDGQVLQKLF EKLEGEKLNV AEVTQSEIAQ KQKLQTVLER INDALKVSTR
NTKWNVDSVH AKSMVAILHL LVALSQHFRA PIRLPDHVSI QVVVVQKREG ILQSRQIQEE
ITERDAFDTL FDHAPDKLSV VKKNKANRTD VFQVRETLTY VLLERLFFLV FSTDGFYYSV
LSLLQVHNVS FAFELMQDGG LERPKPRPED IVNCDLKSTL RVLYNLFTRY RHVE
//
