ID W5L879_ASTMX Unreviewed; 485 AA.
AC W5L879;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Potassium voltage-gated channel modifier subfamily V member 1 {ECO:0000313|Ensembl:ENSAMXP00000016041.1};
GN Name=KCNV1 {ECO:0000313|Ensembl:ENSAMXP00000016041.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000016041.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000016041.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_007228931.1; XM_007228869.1.
DR STRING; 7994.ENSAMXP00000044069; -.
DR Ensembl; ENSAMXT00000016041.2; ENSAMXP00000016041.1; ENSAMXG00000015593.2.
DR Ensembl; ENSAMXT00000046960.1; ENSAMXP00000044069.1; ENSAMXG00000015593.2.
DR GeneID; 103031300; -.
DR KEGG; amex:103031300; -.
DR CTD; 27012; -.
DR eggNOG; KOG3713; Eukaryota.
DR GeneTree; ENSGT00940000159740; -.
DR HOGENOM; CLU_011722_4_1_1; -.
DR OMA; AWFTAEF; -.
DR OrthoDB; 1478695at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000015593; Expressed in brain and 3 other cell types or tissues.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR InterPro; IPR003971; K_chnl_volt-dep_Kv9.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR11537:SF38; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY V MEMBER 1; 1.
DR PANTHER; PTHR11537; VOLTAGE-GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF02214; BTB_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01494; KV9CHANNEL.
DR PRINTS; PR01491; KVCHANNEL.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 198..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 230..248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 330..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 391..411
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 39..146
FT /note="BTB"
FT /evidence="ECO:0000259|SMART:SM00225"
SQ SEQUENCE 485 AA; 54443 MW; D09279E2CC8867A8 CRC64;
MISNASSAAE FCGDSASVLS LDSSVFFSEP PPPSDNPLDF FIINVGGSRY ILSQELLASH
PETRLGKLAL STRDSALDLC DDADFLENEF FFDRNSQTFQ YVMNFYKTGH LHVREELCVV
SFLQEIEYWG IDELRIDNCC RDKYYRRKEM KESLDVHKEA EAADSDEEDF AGVLCQDLRQ
RLWDLMEKPD SSKAAKTFGT LSIFFVVVSI VNMALISLDF TILGASVLDI LEYICIVWFT
GELVLRFLCV KDKCKFSRSV VNIIDLLAIL PFYVTLAVES LHGGSTELEN VGRVVQVLRL
MRSLRMLKLG RHSTGLKSLG MTIAQCYEEV GLLMLFLSVG ISIFATVEYA IEHDIPETTF
TNVPCAWWWA TTSMTTVGYG DIRPDTAVGK VMAFICILSG ILILALPIAI INDRFSACYF
TLKMKEAALR HGEALKRLTR SSASDVTAVG VNLRDAYARS VLEMLRLQGR ERASTRSSAG
DDMWW
//
