ID W5LBE1_ASTMX Unreviewed; 1748 AA.
AC W5LBE1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Poly [ADP-ribose] polymerase {ECO:0000256|RuleBase:RU362114};
DE Short=PARP {ECO:0000256|RuleBase:RU362114};
DE EC=2.4.2.- {ECO:0000256|RuleBase:RU362114};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000017153.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000017153.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ARTD/PARP family.
CC {ECO:0000256|ARBA:ARBA00024347}.
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DR STRING; 7994.ENSAMXP00000017153; -.
DR Ensembl; ENSAMXT00000017153.2; ENSAMXP00000017153.2; ENSAMXG00000016657.2.
DR Ensembl; ENSAMXT00000034316.1; ENSAMXP00000045749.1; ENSAMXG00000016657.2.
DR eggNOG; KOG1037; Eukaryota.
DR GeneTree; ENSGT00940000160555; -.
DR HOGENOM; CLU_001437_0_0_1; -.
DR OrthoDB; 11548at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000016657; Expressed in zone of skin and 14 other cell types or tissues.
DR GO; GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:UniProtKB-UniRule.
DR CDD; cd17726; BRCT_PARP4_like; 1.
DR Gene3D; 3.90.228.10; -; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR031273; PARP4.
DR InterPro; IPR012317; Poly(ADP-ribose)pol_cat_dom.
DR InterPro; IPR013694; VIT.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR46530; PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP4; 1.
DR PANTHER; PTHR46530:SF1; PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP4; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF00644; PARP; 1.
DR Pfam; PF08487; VIT; 1.
DR Pfam; PF13768; VWA_3; 1.
DR SMART; SM00292; BRCT; 1.
DR SMART; SM00609; VIT; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF56399; ADP-ribosylation; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50172; BRCT; 1.
DR PROSITE; PS51059; PARP_CATALYTIC; 1.
DR PROSITE; PS51468; VIT; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|RuleBase:RU362114};
KW NAD {ECO:0000256|RuleBase:RU362114};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transferase {ECO:0000256|RuleBase:RU362114}.
FT DOMAIN 1..92
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 357..557
FT /note="PARP catalytic"
FT /evidence="ECO:0000259|PROSITE:PS51059"
FT DOMAIN 594..722
FT /note="VIT"
FT /evidence="ECO:0000259|PROSITE:PS51468"
FT DOMAIN 860..1030
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
SQ SEQUENCE 1748 AA; 193715 MW; 7942C308F8B53A23 CRC64;
MAVFEGCSVV LDLKKLPYKE KKRLMSAIID YGGNISYVVN QKCSFVVTSS LEDLSSNRLR
SAQKHQIPVV GLQFVWSSLE KGLLLPAEEH GLKPEPSDVT HPPPPHPGMK LSTLFPAELK
SSNQISTRLC KENDLDVPEF PLHFQVAKYT IFHKAASKVW SVLELQSARG EKGQQYRIVK
SVLHETVKTA EKDKQLQSSS SEEAVEVYLI WREELIGKGF TQKQTLPPVA EKLASRGLQQ
LLLEEKLNCS TVTQEVGTFV ELIWTEALGS LNSILTVPVS SISLNDVSRV EGLLLQAQKR
EGEDEVKALL DEVKTLLPLV MVDPDSKQKL ISQKLDLCQL IRDILNMSEA TLGNPSPSSL
GKYRALRCSI DQVPPQSPEF QSVSQLLQDR PVKIQQILRV SRGAEVHMFK EEIGNIKPLL
HSSRPSSFMG ILSRGLMLPR VGVEQHGIER TDVGNLGSGI YFSDSLCTSI KYSKPSEMDG
SRLLLVCDVA LGQCKDLHRR DITLTRAPEG YSSVHGVQQT QNTHTDFEDD EYVVYNTDQV
RIKYVVQYAL EEDQMKSFQP HVDTSVELVN STVSAELLSI DDTEGLESTK NPLEEVTAGL
LDSSGQTLPL QAVHVRCKLM DLLSQVIIFQ TYTNNSTVPI EAKYVFPLEE TAAVCGFEAF
INGKHVIGKV KEKEQARKEY RQAIEKGHGA YLMDQDAPDV FTISVGNLPP GATVLIKVTF
VTELVVRAGS ILFSLPGSVA PWQQSAALNQ RTQMSVEKVC VNELQPSGEF SLSMSIEMPY
EIKDLECSHR IQIKRTDCKA VVSTKPEQTL STDGFQLSFT LSQIHMPRMW VEKHPDKDSE
ACMLVFYPDF ESTGVSSVSD VVILLDTSES MRGEATLNAC RLAIKVLNSL DRSLRVNIIS
FGTDYKEAFP SASVLDNKDV FKSAKTFIMS SPAVGGSTEL WRPLRSLNLL PPSHGVRNVL
LVSDGHVQNQ PQTLQMVREN ARHTRLFTCG LSPTANRHML RALAQAGGGA FEFFDTKKKH
TWSEKVNSQV KCMASPGCSS VAVKWQQFSP TAPSPVQAPS QLHALFSDCH TLVYGFVPHC
TQATLFGDLS GQEIKTMVST TELQKTRGTF LHKLTARAII RDYEDGSLGS SEAEHEGKKA
ELKSYIIELS KEFSILSQFT SFVAIEERDK DQPDSGITDV PKIIAEEDVD ILPYMGWTEE
EDMIVDNEEE WDYAFDEEGY EEVAFYEPVC SPAYAPTSPS ASSIEDNAYA PRRKIQSKIC
KKAASIQLEQ TTSQISDIRK SSLVQENPEF EVLCYREPVK ATPSVTPAAA AVNMPFKFGE
KLVCADALPQ SRQAVPHLPP GAPPTQSFVP FLTAASPLPP PATTQPISNL FGSVATASSG
LFGPTSRSAS SFAPPPPPPV TQPIPELESY TSSDSGLRHD LPPSISFFAP PPILPPILPK
PSAVTPQFSL PPAVKCRKSS SLLKTPDAAI TPTPPDQWKE AVHDIYSKLS ERHRFAPMHS
LPASSILAAE GSVDAPLLPE RMSRLSRHQD ADTSAGFGVF SGGRCGGRRR RRNLVDQSEA
EFSYISHVQC RRMEYRPTRF SLRERLRSPD GINWEELFTL QHQDGYWECT RSLSRFLGLD
IDFFANVFLK EKGICSLGVK AHADILKLVA TLLVLQLMRV KKMVDVELFQ SLFRLSESPE
PRPACYDAVK KAVDWVCWAD RQYPCVCSRL EFGLNWESCT RQLLGLDSLP PCSPLIPVLQ
RSTGISVM
//