ID   W5LHN8_ASTMX            Unreviewed;       522 AA.
AC   W5LHN8;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   27-MAR-2024, entry version 44.
DE   SubName: Full=Sarcalumenin {ECO:0000313|Ensembl:ENSAMXP00000019350.2};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000019350.2, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA   Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA   Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000019350.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; W5LHN8; -.
DR   STRING; 7994.ENSAMXP00000019350; -.
DR   Ensembl; ENSAMXT00000019350.2; ENSAMXP00000019350.2; ENSAMXG00000018789.2.
DR   GeneTree; ENSGT00940000157834; -.
DR   InParanoid; W5LHN8; -.
DR   OrthoDB; 12127at2759; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   Bgee; ENSAMXG00000018789; Expressed in heart and 7 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   CDD; cd09913; EHD; 1.
DR   Gene3D; 1.10.268.20; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR045063; Dynamin_N.
DR   InterPro; IPR031692; EHD_N.
DR   InterPro; IPR030381; G_DYNAMIN_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR43681:SF1; SARCALUMENIN; 1.
DR   PANTHER; PTHR43681; TRANSMEMBRANE GTPASE FZO; 1.
DR   Pfam; PF00350; Dynamin_N; 1.
DR   Pfam; PF16880; EHD_N; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51718; G_DYNAMIN_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT   DOMAIN          138..379
FT                   /note="Dynamin-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51718"
SQ   SEQUENCE   522 AA;  59414 MW;  D28175003CA97B3C CRC64;
     MLATQQANLD ARPLCHMPLD LLRVVYIVSQ AFRVLLPANM KGLVSICCLV SLLSLATPEE
     EELLDSILRD RSHIEETLRL AALDTSGDYA AALQRLRKIY HNSIRPMEQA YKYNELRQHE
     ISAYPGRTLG DSATDGEITS KPMVLFLGPW SVGKSSMINY LLGLRDTPYQ LYTGAEPTTS
     EFTVIMHGEK IRSVEGIVMA ADSSRSFSPL EKFGQNFLEK LIGIEMPHKL LERVTFVDTP
     GIIENRKQQE RGYPFNDVCQ WFIDRADLIF VVFDPTKLDV GLELEMLFRQ LKGRESQIRI
     ILNKADSLAT QDLMRVYGAL FWSLAPLINV TEPPRVYVSS FWPYDYAADT SRELFKREEI
     SLLEDLNQVI ENRLENKIAF IRQHGIRVRI HGLLVDRYVQ TFKEKMSFFS DPELVFKEIV
     DDPDKFYIFK SILAKTNVSK FDLPNRDAYR DFFGINPVSS FKQLSAQCSY IGGCLLDKIE
     RAITADLPGL LSSINSGKNP TLSSCEATGC GEKPKNRYRR GN
//