ID   W5LHU0_ASTMX            Unreviewed;      1030 AA.
AC   W5LHU0;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   27-MAR-2024, entry version 47.
DE   SubName: Full=Cilia and flagella associated protein 70 {ECO:0000313|Ensembl:ENSAMXP00000019402.2};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000019402.2, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA   Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA   Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000019402.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; W5LHU0; -.
DR   STRING; 7994.ENSAMXP00000019402; -.
DR   Ensembl; ENSAMXT00000019402.2; ENSAMXP00000019402.2; ENSAMXG00000018831.2.
DR   eggNOG; ENOG502QSJ2; Eukaryota.
DR   GeneTree; ENSGT00390000013319; -.
DR   HOGENOM; CLU_009208_0_0_1; -.
DR   InParanoid; W5LHU0; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   Bgee; ENSAMXG00000018831; Expressed in olfactory epithelium and 6 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR44314; CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 70; 1.
DR   PANTHER; PTHR44314:SF1; CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 70; 1.
DR   Pfam; PF12895; ANAPC3; 1.
DR   SMART; SM00028; TPR; 7.
DR   SUPFAM; SSF48452; TPR-like; 2.
DR   PROSITE; PS50005; TPR; 3.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        799..823
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REPEAT          660..693
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          877..910
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          914..947
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REGION          768..788
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1030 AA;  115224 MW;  EC9FB9F0DD2933AF CRC64;
     SMDTQQAAAG VPVQITVERG NNLRGNKSEP FLSFVRAEFN GTVLGDSQKL DVPLDDCVNF
     SFTCSFQCSE TEHTLNDLAK EPVILTVTEV FPKEKKQKQD RTSVLGQAVL DLIPLLHGES
     RFSSTVTLHP VPESSTETST QTGGVTPTLE VTVSVPELLL SDSQLSQSNL LSVTVETAYS
     VPDAWNPATL PPSIYTAALQ IPLTAEKEQI LLFSNGILKT GGERETAPRP KKWPLSPRLA
     PDAQPIPGVF IEREPTDFED GDLTSVEDRE FRAEAECNQK RVSWDTECRC FLDAGGAAGL
     TRRIAECRLW PLEVMKSPQA AKAAGGKSSK EKQVDDEIQI PFHGVAYMDL TPLLYPGVKR
     IRGAYMLHPF YNSELQTKTK RTMSVLRESL KTSAAPPRLR RSSSAASYKA AAGKKVQLVK
     LLFIFDYSVV KVSQTENITD AEPQVNTEGE MYADSGSYII IEITLEKPLV PKRPLEELAN
     RVKELIPPRP ALPRRPAGAE RAVREYQAQI ESVASQVLDQ YQQMFGAAFV PGAEPLDPAT
     TEQRKSRIYG ELNCSGKYFA FKEQMKYAVV RIVREKMLRT KAFTDPEQLQ AFLSQLYIFL
     VDEMHAALNK TLSANGEEVQ AQTLLDCCQL KHFAREAQLN EDYQLAAHYY QERLSQDQSP
     SHWFDYGAFH MLMADYLKAE ECFQTAVAIH QEHVPSLLMC GILAEMSRRY RDAETFLERA
     TSIEPSSVVA WTVFGLFYLA QENPIRAEMA FLKATKLQAA LTRLPEVDST QTQVEGGQGQ
     EVGDSESLSN TPDETDVCLS LSLICVYVYV CVCVCVCVCV YVLKMAQRAL AQELLCPDGG
     PSSWYDLSLA HLQFLQGQYS SAEISLQEAL TDHFQNPDAW ALCGHLYYLM KDNKQAVKCY
     ERTLDFVTDS SDPHPVYLRL ASIYLQNREY EKAKSTYLRA CRSSPSCRTW LGLGISCYRL
     GEMTEAEDAL AEANILNNQN PEVWAYLALV CLQTGRKLEA EQSYKYTLQA LLQEIRQLQE
     RFGFGNPFFP
//