ID W5LIL4_ASTMX Unreviewed; 449 AA.
AC W5LIL4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Galactosylceramide sulfotransferase-like {ECO:0000313|Ensembl:ENSAMXP00000019676.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000019676.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000019676.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the galactose-3-O-sulfotransferase family.
CC {ECO:0000256|ARBA:ARBA00008124}.
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DR AlphaFoldDB; W5LIL4; -.
DR STRING; 7994.ENSAMXP00000019676; -.
DR Ensembl; ENSAMXT00000019676.2; ENSAMXP00000019676.2; ENSAMXG00000019106.2.
DR eggNOG; ENOG502QUJ6; Eukaryota.
DR GeneTree; ENSGT00950000182923; -.
DR HOGENOM; CLU_040616_1_0_1; -.
DR InParanoid; W5LIL4; -.
DR OrthoDB; 4316359at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000019106; Expressed in camera-type eye and 3 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0001733; F:galactosylceramide sulfotransferase activity; IEA:InterPro.
DR GO; GO:0009247; P:glycolipid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR009729; Gal-3-0_sulfotransfrase.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR14647; GALACTOSE-3-O-SULFOTRANSFERASE; 1.
DR PANTHER; PTHR14647:SF84; GALACTOSE-3-O-SULFOTRANSFERASE 2-LIKE ISOFORM X1; 1.
DR Pfam; PF06990; Gal-3-0_sulfotr; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT REGION 38..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..61
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 449 AA; 51581 MW; CFFDB2413C5DE43B CRC64;
MTLRWLSTQL WRHRVTGLLV TLAVTVILML LATQSLQSTR TRNVRPAGEK RTQKGREHKQ
TPARPGSAPT HIASHEQETK ARLLPTAELS NQSVKKRRHP PPVAFLKTHK TGSSTVQNLL
FRLGEKEKAT FAFPYYTYQF SYPERFRAEF VDELPEDSSQ FDLLCSHMRL DLNQLKKVMP
LNAILITILR EPLRTFESVF SYYTSSVHAF SRAKEIAARP ENKGRTALSV FLDDPESLWD
PKVPSNHLAK NPMSFDMGLN NEEWNASWPE DLYRLEEAFD LVMIAEHFDE SLVLLGALLG
LEPQDLAYVQ MNTRHASDVT ALDEDSRVKL RSWNALDSLL YDFFLQEFWI KAEHYGLNRL
KAGVAELKAS TEKIRNNCVS RSAVPPSELE DLVRPWQTDT ATILGYEVQK NLSLEDQGFC
VRLVLPELQY HSHLYFQQYG RDMRSVPSD
//
