ID W5LL80_ASTMX Unreviewed; 498 AA.
AC W5LL80;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=NACHT LRR and PYD domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000020592.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000020592.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5LL80; -.
DR Ensembl; ENSAMXT00000020592.2; ENSAMXP00000020592.2; ENSAMXG00000020013.2.
DR GeneTree; ENSGT01100000263476; -.
DR HOGENOM; CLU_002274_4_1_1; -.
DR InParanoid; W5LL80; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000020013; Expressed in intestine and 5 other cell types or tissues.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00368; LRR_RI; 4.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS51450; LRR; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..498
FT /note="NACHT LRR and PYD domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017276315"
FT DOMAIN 69..126
FT /note="NOD2 winged helix"
FT /evidence="ECO:0000259|Pfam:PF17779"
FT DOMAIN 128..256
FT /note="NACHT LRR and PYD"
FT /evidence="ECO:0000259|Pfam:PF17776"
SQ SEQUENCE 498 AA; 56100 MW; 3FEE4A3B87740E43 CRC64;
MCHIPVFCWI AATVLDRMLG EAETGEIPKT LTQMFTHFLI FQIKHRNQKY HKKCDHDPQK
RILETKENIL ALGKLAFQQL EKGNLIFYEE DLKECGINIR EGSVCSGVCT QIFREELLHL
GKVFSFVHLN VQEFLAALYV YISFFNKDGK EQLATDLSDL FNQSTMSDLL KSAVDKALQS
ENGHLDLFLR FLLGLSLESN QTLLSGLLTV AERSSHHKED TVQYIKEKIR ENPSTEKSIN
LFHCLNELNN HSLVQEVQEY VNRRNHHPGK DRLSPDLWSA LVFVMLNSDE KLDNFDLHEY
HPSEESLLFI LLILEDGCVP KKHCILLILP EITLCANLAS ALSCSSLIEL DLSYNKLGDS
GVQLLSNGLK NPNFLHFMIY LSGCNLTGKS CAAISSSLSS NYSHLSTLNL SNNKLLQDSG
VKLLSTGLKS SHCKLEILML CNCSITDEGY TDLASALKSN PSSHLRELNL DYNKSGESGV
KLLSELQEDP HSNLKKLL
//
