ID W5LLD7_ASTMX Unreviewed; 2539 AA.
AC W5LLD7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Ubiquitin protein ligase E3 component n-recognin 5 {ECO:0000313|Ensembl:ENSAMXP00000020649.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000020649.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000020649.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 7994.ENSAMXP00000020649; -.
DR Ensembl; ENSAMXT00000020649.2; ENSAMXP00000020649.2; ENSAMXG00000020014.2.
DR eggNOG; KOG0943; Eukaryota.
DR GeneTree; ENSGT00940000156357; -.
DR HOGENOM; CLU_000257_0_0_1; -.
DR InParanoid; W5LLD7; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000020014; Expressed in olfactory epithelium and 14 other cell types or tissues.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd19675; UBR-box_UBR5; 1.
DR Gene3D; 1.10.1900.10; c-terminal domain of poly(a) binding protein; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 2.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 1.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR036053; PABP-dom.
DR InterPro; IPR002004; PABP_HYD.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR047503; UBR-box_UBR5.
DR InterPro; IPR003126; Znf_UBR.
DR PANTHER; PTHR46276; E3 UBIQUITIN-PROTEIN LIGASE UBR5; 1.
DR PANTHER; PTHR46276:SF1; E3 UBIQUITIN-PROTEIN LIGASE UBR5; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00658; PABP; 1.
DR SMART; SM00119; HECTc; 1.
DR SMART; SM00517; PolyA; 1.
DR SMART; SM00396; ZnF_UBR1; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF63570; PABC (PABP) domain; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS51309; PABC; 1.
DR PROSITE; PS51157; ZF_UBR; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 925..993
FT /note="UBR-type"
FT /evidence="ECO:0000259|PROSITE:PS51157"
FT DOMAIN 2118..2195
FT /note="PABC"
FT /evidence="ECO:0000259|PROSITE:PS51309"
FT DOMAIN 2255..2539
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT ZN_FING 925..993
FT /note="UBR-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00508"
FT REGION 75..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 745..825
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1263..1487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1605..1637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1733..1770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1862..1891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2073..2133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2213..2233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..90
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..348
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..378
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 763..781
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 794..818
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1274..1299
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1311..1325
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1370..1399
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1408..1433
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1447..1487
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1623..1637
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1745..1764
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1862..1883
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2078..2111
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2213..2231
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 2508
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 2539 AA; 280500 MW; 7494435A2A29B208 CRC64;
MSLLDADIHS AHPSVIIDAD AMFSEDISYF GYPSFRRSSL SRLGSSRERD SELLRERESV
LRLRERRWLD GASFDAERGS TSREGEPSVD KKSVPLQSPV SLGEELQWWP DKDGTRFVSI
AAMFSELVAI SSKGELYQWK WSEPEPYRNA QNPSIHHPRV SFLGLANEKI TLLSANSIRA
TVATETNKVA TWVDETLSSV ACKLEHGAQT FPELQGERIV SLHCCSLYTC AQLDSSLYWW
GVVPFSQRKK MLEKARAKNK KPKSSAGIAS IPNITVGTQV CLRNNPLYHA GAVAFSVSAG
VPKVGVLLES VWNMNDSCRF QLRSPESLKS MEKSTKAQEI KTESKPELVK TEMGPPPSPA
STCSDTSSIA SSASLPYKRR RSTPAPKEEE KVNEEQWPLR EVVFVEDVKN VPVGKVLKVD
GAYVAVKFPG TSSSVSSQSA APTDSDPSSL LQDCRLLRID ELQVVKTGGT PKVPDCFQRT
PKKLCIPEKA EILAVNVDSK GVHAVLKTGS WVRYCIFDLA TGKAEQENHF PTSNLAFLGQ
SERNVAIFTA GQESPIILRD GNGTIYPMAK DCMGGIRDPD WLDLPPIASL GMGVHSLANL
PSNSTIKKKA AIIIMAVEKQ TLMQHVLRCD YEACRQYLVS LEQAVLLEQN PHALDALLGH
RCDGNRNLLH ACVSVCFPVS NKETKEEEEA ERSERNTFAE RLSAVEAIAN AISVVSSNSS
GNRTGSSSSR GLRLREMMRR SLRAAGLGRH ESGPSSADHQ DPVSPPIAPP SWVPDPPPMD
PDGDIDFILA PAVGSLTTAS TGPSQGPSTS TIPGPSSEPS VVESKDRKAN AHLILKLMCD
SVVLRPHLRE LLSAKDARGM TPFMLAVSGR AYPAAITVLE AAQKIAKGEP GIGEKEDVNS
VFMEMICPAG TNPDDSPLYV LCCNDTCSFT WTGAEHINQD IFECRTCGLL ESLCCCTECA
RVCHKGHDCK LKRTSPTAYC DCWEKCKCKT LIAGQKAARL DLLYRLLTTT NLVTSPNSRG
EHILLFLVQT VARQSVEHCQ YRPPRIREDR NRKAANAEDS DMPDHDLEPP RFAQLALERV
LQDWNALKCM IMFGSQENKD PLSASSRIAH LLPEEQMYLN QQSGTIRLDC FTHCLIVKCA
PDITFIDTLL GTLVKELQNK YTPGRREEAI CVTRRFLRSV ARVFVILSVE MASSKKKNNF
IPQPIGKCRR VFQALLPYAV EELCNVAESL IVPVRMGIAR PTAPFTLAST SIDAVQGSEE
LFSVEPLPPR PSPDQSSNSG QSASSYIIRN PQPRRSSQSQ TARGRDEEQD DIVSADVEEV
EVVEGVAGEE DHHDDQEEQG EETAEAEGQH DEHDEDGSDM ELDLLAAAET ESDSESNHSN
QDNASGRRSV VTAATAGSEA GASSVPAFFS EDDSQSNDSS DSDSSSSQSD DADQETYLLD
EPLERTTGSA HANSAAQAPR SMQWAVRTTP SQRSAGGAPA SSSTPAASST GLIYIDPSNL
RRSSAISTSA AAAAAALEAS NSSSYLTSAS SLARAYSIVI RQISDLMSLI PKYNHLVYSQ
YPAAVKLTYQ DAVNLQNFVE EKLIPTWNWM VSIMDSTEAQ LRYGSALSSA GDPGHPSHPL
HASQHAGRRE RMTAREEASL RTLEGRRRAA TLLTARQGMM SARGDFLNYA LSLMRSHNDE
HSDVLPVLDV CSLKHVAYVF QALIYWIKAM NLQTTLDTTQ IDRKRNRELL ELGLDNEDSE
HENDEDTNQS STLQDKEEES VSSETGQHHP FFRRSDSMTF LGCIPPNPFE VPVAEAIPLA
DQPHLLQPNA RKEDLFGRPS QGLYSSSYMA SKGLSDLTVD MNCLQILPTK MSYSANMKNV
MSMESRQRGS EDQPTSAQEM DTSKPGPSPH DLAAQLKSSL LAEIGLTESD GPPLPTFIPH
CSFMGMVISH DMLLGRWRLS LELFGRVFME DVGAEPGSIL TELGGFEVKE SKFRREMEKL
RNLQSRDLAL EVDRDRDQLI QQTMRQLNTH FGRRCATTPM AVHRVKVTFK DEPGEGSGVA
RSFYTAIAQA FLSNDKLPNL DCVQSVSKGM QASNLMQRLR NRDRERERRS GGLRAGSRRD
RDRDSRRQLS IDTRPFRPAS EGNPSDEPDP LPAHRQALGE RLYPRVHAMQ PAFASKITGM
LLELSPAQLL LLLASEDSLR ARVEEAMELL ITHGRENGAD SILDLGLLDT PEKAQENRKR
HGSTRSVVDM ELDDPDDGDD NAPLFYQPGK RGFYSPRPGK NTEARLNCFR NIGRILGLCL
LQNELCPITL NRHVIKVLLG RKVNWHDFAF FDPVMYESLR QLIRHSQTGE AEAVFAAMDL
AFAIDLCKEE GSGQVELLTG GANMPVTPQN VYEYVRKYAE HRMLVVAEQP LHAMRKGLLD
VLPKNALEDL TAEDFRLLVN GCGEVNVQML ISFTSFNDES GENAEKLLQF KRWFWSIVEK
MSMTERQDLV YFWTSSPSLP ASEEGFQPMP SITIRPPDDQ HLPTANTCIS RLYVPLYSSK
QILKQKLLLA IKTKNFGFV
//