ID W5LLI5_ASTMX Unreviewed; 1543 AA.
AC W5LLI5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=DNA-binding protein RFX7-like {ECO:0000313|Ensembl:ENSAMXP00000020697.2};
GN Name=RFX7 {ECO:0000313|Ensembl:ENSAMXP00000020697.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000020697.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000020697.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 7994.ENSAMXP00000020697; -.
DR Ensembl; ENSAMXT00000020697.2; ENSAMXP00000020697.2; ENSAMXG00000020093.2.
DR eggNOG; KOG3712; Eukaryota.
DR GeneTree; ENSGT01050000244970; -.
DR HOGENOM; CLU_252972_0_0_1; -.
DR InParanoid; W5LLI5; -.
DR OrthoDB; 2961139at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000020093; Expressed in muscle tissue and 7 other cell types or tissues.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR Gene3D; 6.10.140.1290; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR003150; DNA-bd_RFX.
DR InterPro; IPR039779; RFX-like.
DR InterPro; IPR040889; RFX5_N.
DR InterPro; IPR047009; RFX5_N_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12619:SF2; DNA-BINDING PROTEIN RFX7; 1.
DR PANTHER; PTHR12619; RFX TRANSCRIPTION FACTOR FAMILY; 1.
DR Pfam; PF18326; RFX5_N; 1.
DR Pfam; PF02257; RFX_DNA_binding; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51526; RFX_DBD; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 101..176
FT /note="RFX-type winged-helix"
FT /evidence="ECO:0000259|PROSITE:PS51526"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 571..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 642..677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 995..1060
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1084..1105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1373..1406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 642..660
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 995..1013
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1027..1060
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1543 AA; 165517 MW; DAA0996C7444C19F CRC64;
MMAEDQQPEP NPQPGSGTGS LSSLLPAGLQ GTETSALQLK IKNSICKSVQ SKVDGILQDV
EKFTDIEKLY LYLRLPSGPS SCAEKTEQSC LSSSRSQQMH AFGWIRNHLE EHPETSLPKQ
EVYDEYKSYC DNLGYHALSA ADFGKIMKNV FPNMKARRLG MRGKSKYCYS GLRKKAFIHM
PSLPSLELHK TGDGCEVFEP IGHCSSGEDE VRSASCGLVC EWAQKVLSRQ FDSVEDLARY
LLNSHYIGTK SVAAFTVMTG SPSGSTMSLQ SSAFVPTTDA HSFQPQVKTL ASPSIDAKQQ
LQRKIQKKQQ EQKLHSPLPA EAQARRADGG ITPGASIGIP CGSPALLSPQ PTIGIVVAAV
PSPITVQRSR QLMSPSPVPI ATAESKVLPV NFQVVTQAVQ PVKQCPKTPQ NVPASPVGDR
SARHRYAQIL PKPPSTSAIT LRSPPALLIT NSPIKTVMPT TQVSSVNVVK MTTISLGHSN
SNTATISTTR STPRPASAGV ASLTDDLQPV TRVRSGSLAA MPSMLARRGR LATVTTPVTD
IRLGSDTVPG SGQAQGCATG RLATPQEAAE GVEGVDGSSK PRAASVPTPL KISTGLDMGT
GTKCNGRMLP RENSLAAGSN INNNGKERAS YQGVPVQAMS LSSTPTVSSS AFVSSTRDAE
LTSKSPRKRQ GLCPDSSHLT PVKKVFLTDE GTHSTTSGMG TTVQNMLRSD APIRPVSAPA
SAVGKVLVKL NSNVPTRILA HSDSPVGNTG FQTISRPRSI SHGHWEGSSS CVKSIAATST
AASTAPAPLF RNTSFQAFGR PRSVSQGRWE GPASIIDSKS LVTHTASATG PALLQQHATK
DPPVMRMSSE QANIAACELE KSVFWDSGQQ QNGTQQVYSQ QGSLESKQIS TPVMEPHQVM
AQHSAPSQLV QVTNDMAEYV STQPNVGYFP FNDDDMTQDS IVEELVQMEE QMKMNSGMQD
FGGCVDMALQ GQQATLQQNN MISNHQPNTT YYRSAHSRST PIQTPTPTPT PTAEMMGGGQ
GLTRESPCSR LAPTTPVDSA LGSSCQTPIS TPHSNCSSSV PPSPVECRNP FAFTPINSSI
TSYHDGSIVS SSPVKPMQRP MATHPDKSKL EWINNGYNSG SGNSSNGISI LPSYQDLVDD
QFRKPHAFAI PGQTYQSQIR HHDTHVSRLT PMSPVQQQVA SMANLNKQEG FAVPAPLDNK
TSNSSSGSVT FRCRSVSPAV RQRNLSGTQN PNVPRSVVSP FNSPVTPEVL NIFANSQADT
SITSMAQRSQ SVPLNVMMQT EVLPMQACGQ PSNTKKITNV LLSKMDGDGD SLVRGLGMNN
MPSYTARMNL TQILETSAAP SFPSGANHQA QISPGPSAYR FQKPAYLTKN ARGDQMSLST
GDGQGHAQSL TGEKQQQQHH QQQLSVEEQQ NQAMLVRQQQ NLQQHQHQQP LHFDSTVKDL
LEANSLNAGS QLSGQVSELS AGSSEFPGDM RLASELSSSI NDLNTLDTNL LFNPSQQQGQ
YEESTLEELK NDPLFQQICS ETVNSAGFDW LENKDQATVE MLG
//
