ID W5LME9_ASTMX Unreviewed; 758 AA.
AC W5LME9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN Name=OSBPL10 {ECO:0000313|Ensembl:ENSAMXP00000021011.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000021011.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000021011.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the OSBP family.
CC {ECO:0000256|RuleBase:RU003844}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; W5LME9; -.
DR STRING; 7994.ENSAMXP00000021011; -.
DR Ensembl; ENSAMXT00000021011.2; ENSAMXP00000021011.2; ENSAMXG00000020402.2.
DR eggNOG; KOG2210; Eukaryota.
DR GeneTree; ENSGT00940000157880; -.
DR HOGENOM; CLU_012334_3_1_1; -.
DR InParanoid; W5LME9; -.
DR OrthoDB; 1018068at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000020402; Expressed in testis and 12 other cell types or tissues.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd13291; PH_ORP10_ORP11; 1.
DR Gene3D; 1.10.287.2720; -; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10972:SF47; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 10; 1.
DR Pfam; PF01237; Oxysterol_BP; 2.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU003845};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT DOMAIN 57..154
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 196..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 308..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..58
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..350
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..387
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 758 AA; 83629 MW; 0C440E5911C46DFA CRC64;
MERACGGVSR CGSSRTVAAA GERGKPTVRP GNSSPRAGRS SSPSPGRGSG NPSQSHKRHL
EGVLNKYTNL LQGWQNRYFV LDPELGQLQY FLNEQSKNQK PRGSLPLIGS SVAPSDEFPF
MFTVYAANGE LFKLRACDAC ERQLWMNQLQ LCARRHSDSS AKGCRTSSST FSSSFAGRTR
SFSLLPHPAP PCSSINTQRQ NTPHGHGNPG SIITITHHKS PTSSQRASNH SPAPLHQVKE
VMSQAEGQQK NLLNSIESLP SRGPLSSLDP DLLLLKATSA ATLSCLGECL SILQHNVSQA
ARNITTHTQG LNTENVTGWS GHKPASEEPL KNGGVTGLST STSNTPPISP AHRSKELLKG
SENSSPDAVD PSEESTDTED NEEEDLGVLD DQRSIIIHLL SQLKLGMDLT RVVLPTFILE
KRSLLEMYAN FMAHPDMFLA ITSGTTAEER IVRFVEYYLT AFHEGRKGAV AKKPYNPILG
ETFRCSWDVP RERVRPLRTT SSPCPVPPAS AKPGDCCRLW FVAEQVSHHP PVSGFYCECK
ERRMCVNTHV WTKSKFMGMS VGVSMVGEGV LHLLEHDEQY VFTLPCAYAR SILTVPWVEL
GGKVSICCAK SGYSATVTFH TKPFYGGKVH RVTAEVKHNP TNTIVCKAQG EWNGTLEFTY
SSGESKVIDT SKLPVIKKKI RPLEKQSQYE SRRLWQHVTA ALKTGDIDTA TEHKHQLEER
QRSEGKQRAA TSTPWKPKYF IKEGEGWVYH NPLWKTNC
//
