ID W5LTH1_ASTMX Unreviewed; 882 AA.
AC W5LTH1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=SLIT and NTRK like family member 3 {ECO:0000313|Ensembl:ENSAMXP00000026433.2};
GN Name=SLITRK3 {ECO:0000313|Ensembl:ENSAMXP00000026433.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000026433.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000026433.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SLITRK family.
CC {ECO:0000256|ARBA:ARBA00010439}.
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DR AlphaFoldDB; W5LTH1; -.
DR STRING; 7994.ENSAMXP00000026433; -.
DR Ensembl; ENSAMXT00000026454.2; ENSAMXP00000026433.2; ENSAMXG00000025728.2.
DR eggNOG; ENOG502QYY5; Eukaryota.
DR GeneTree; ENSGT00940000158681; -.
DR HOGENOM; CLU_012706_0_0_1; -.
DR InParanoid; W5LTH1; -.
DR OrthoDB; 4169326at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000025728; Expressed in brain and 1 other cell type or tissue.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007409; P:axonogenesis; IEA:InterPro.
DR GO; GO:1905606; P:regulation of presynapse assembly; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR043326; Slitrk.
DR PANTHER; PTHR45773:SF9; SLIT AND NTRK-LIKE FAMILY, MEMBER 3B; 1.
DR PANTHER; PTHR45773; SLIT AND NTRK-LIKE PROTEIN 4-RELATED; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00369; LRR_TYP; 11.
DR SMART; SM00082; LRRCT; 2.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS51450; LRR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT DOMAIN 228..278
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT DOMAIN 554..604
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT REGION 302..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..352
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 882 AA; 98807 MW; 5DD910F52B83A616 CRC64;
MHSTAFGERM LWLTLLSTLA LGWTTPIPLL DESEEIDEPC FEPCYCEVKE GLFHVHCDSK
GFTNVSQVAQ SWMRPFKLYL QKNSLRKLYF NSFLHLNNAI AINLGNNALQ DIHAGAFNGL
SSIKRLYLHE NKLEVFRNDT FLGLESLEYL QADYNVIKRI DSGAFRNLHK LRVLILNDNL
IPVLPTFLFR SVSLTHLDLR GNRLKTLAYR GTLEYIGRSL MEIQLEENPW NCVCDIVQLQ
AWLERIPYTA VVGEITCEYP FHLHGKDLRE IKRSELCPML TEAEVEANLG IPHLPFYTGR
VRPTKPSSMV SPNQNTVSSV EQRERPPKPT KRPRPSKTPP TPRSAFPNQP PVAGYQTRPP
IPIICPIGCT CNLHINDLGL TVNCKESGFR NISELMPRPL NAKKLYLSGN LIQKIHKSDF
WNFSSLDLLH LGNNQIFYVQ EGAFANLPNL RSLYLNGNNI ERLTLDMFHG LQSLRYLYFE
YNEIREIQPA AFSLMPTLQL VFLNNNLLRT LPVGAFAGTS LARLNLRNNY FHHLPVSGVL
EHLHAVVQID LNQNPWDCSC DIVPLKEWLD TLSSVVIVGE VVCKTPEAMN GKDLRSLNAE
VICPELLQPS SSPEDWAKGL STSFPGAGPH PPKGTIPLSV LILSLLVLFV SAFFAAAALC
AYALKKREKL PFRKQGEVGL AGIQMECGIF TEPPPALPET PPSNHVYDCI ATPSSHMCSN
PIYKSGRQGG VDQKHPLTDS GESGSNYRTL LEKEKEWTMA IGSSPVNTIV PVGAPCADIS
GLHENGILCP TVIDSQGPTP KVGFVDSLFG TPLFSDVPDR HVHPPPEYPH AEQDARQTQT
LTINTGTRTG CPNQVHSEYP ELRARLKTKV DYIDVLERSY QF
//
