ID W5LWU8_LEPOC Unreviewed; 1862 AA.
AC W5LWU8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Histone-lysine N-methyltransferase SETD2-like {ECO:0000313|Ensembl:ENSLOCP00000000605.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000000605.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000000605.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR STRING; 7918.ENSLOCP00000000605; -.
DR Ensembl; ENSLOCT00000000606.1; ENSLOCP00000000605.1; ENSLOCG00000000548.1.
DR eggNOG; KOG4442; Eukaryota.
DR GeneTree; ENSGT00940000160086; -.
DR HOGENOM; CLU_236613_0_0_1; -.
DR InParanoid; W5LWU8; -.
DR OMA; AVESHAH; -.
DR Proteomes; UP000018468; Unassembled WGS sequence.
DR Bgee; ENSLOCG00000000548; Expressed in camera-type eye and 10 other cell types or tissues.
DR GO; GO:0005694; C:chromosome; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046975; F:histone H3K36 methyltransferase activity; IBA:GO_Central.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR006560; AWS_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR042294; SETD2_animal.
DR PANTHER; PTHR46711; HISTONE-LYSINE N-METHYLTRANSFERASE SETD2; 1.
DR PANTHER; PTHR46711:SF1; HISTONE-LYSINE N-METHYLTRANSFERASE SETD2; 1.
DR Pfam; PF17907; AWS; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00570; AWS; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51215; AWS; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT DOMAIN 1689..1743
FT /note="AWS"
FT /evidence="ECO:0000259|PROSITE:PS51215"
FT DOMAIN 1745..1862
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 125..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 619..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 669..729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1155..1216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1232..1390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1507..1624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..277
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..299
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..371
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..397
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..452
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..480
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 481..495
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..529
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 530..589
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..690
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1155..1172
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1189..1203
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1232..1251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1260..1306
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1311..1369
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1522..1540
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1548..1566
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1577..1621
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1862 AA; 207073 MW; 7C8EB0D4A85DC12B CRC64;
MTKKPLQNRF LAPLSPEKPA SDSQISVLTS VAVSAPTQDK VGQHPESRSE QIEPLSLVAE
SITPSPFVPS PLKPKLDLGK MHFKKQLLSV TAKLESTGEK EEPLLVPSMA VGAPSEAELQ
VELKTAAKAE TESQTPNAVE HSTLEDSVKE KPGLCQQSPG NTSHIGKEEN DTEGLKNVQC
TETSDPRKNQ PQLENTLPGS ESDGDSVRTS SSHKSGDIKS STAHAESRSK EVKRNSSVSK
GEESEKSSYS RTRSEKDDRH SSYSKSDRES RHTSLRSSRS ERQRRRSRSR TRSRSRGSRK
SSSYSRSERS LRSERSTRSE RSHYHDSDRR SHRSTPHRER SCSSRSRTDI RSRDSSESED
DHRRTRSRGS DSKRSSTNSI SHRESKTTTT SSSYSKSEKD CKTTEPSHSS ETEKKMQSNS
RSERDSRRNV DLESIRKTSP EMELDRRKSN AGSKLESSVN STHSKPRTRS QTSEKASQKM
TSSSESEEEQ EKSQLHSSET SSSASGSDER QTTSASKMDK PDVKRSSSPK PTDLQKPTTE
TNKCVQETER QSMGKSSSPK TVTLQSDTNK LCSQTEDGGG MKESCPTNNS QCNEMDSKQC
CHDATPYLKD FQNLTVPEPG LTDSSLAQDC KQSGPPDKIK SFIKIEKLST YSLRSHSKVQ
KFDVAKELGD LPSPSMPDLQ NVQALDTNKA LTMYDDTDVD SREPKAQPSA ESSQQEHPDC
PGRDIDSSAL PQSLVDNREE TATASCEIPV DSCVTMVSCE QPSNLGSLCS SLDNVPLSNV
SSTEISLEHR TGVLKTAEED KTVINVERVC MEEDVEVTND LPSHMTKSSP EGINVGKDIA
VGNIQRLPEL KQDNQHSQTS LEICTDEQLI QKESPLTNCS AFSKDEPSLC IEALYLRGCD
SPTKSEIPNN ADSPYSGLSH CNTSTYKLIS SDREETGSLQ SSTVSLEEGS FSKVDSCSVK
DLNLTLNEFA SSNVTEQKNA PISKPTKGNV KKSRWDIVGQ ETSDQETSPR RSRLETKPYI
KKVVSVRRIH LSKDSNPDTK EICMKEEPIF KQECPVIVEH NLNEDHVNVA GLFSAAKVAD
VKTEETVDQA DSSLVRQQKN ISDIKSKPEP LNAPTQPFFE DDSDAFKNNE EEMVVGCSTV
NDPHGTQLPL VANEEGLKKE EEEEDMVRQR QCLWKSKPDS SNMSLEREGE DSEDSETEES
DLDSDDSGVP RNRLQSVVVV PKNSTLISIE GRAIITPSSS PSNSPGRPSS DWAEHSWTEP
FGRGADRDGS GEGTRRDTSR SRSVSPERRR RGGPVKMSES CKRVHEVPTA DTISFPQSTG
YPSQSNMVDS TSQSEASRAH CSQHHTKPTQ THGQDKPKTL TTLGSVHDPQ NSWGELDLGD
SRHYERPDSW QGRKWGRRLP RYQPGDFTRA DGFCNKDDYN LGWDYTQAEQ PTSTYQQPDS
SHGVHLDKTY QLQQQQQQQN PLQEVIPLTG QPWWQDNGYW APPGPQSCRP VCPPMALQYR
ESVGQVHPDS LTNDYDDESR GKSGPSLTSL LDSSVSATAP CDPPPSAPSS FVQANEVSSN
CRGPISAAPE SSAISEAPRE ESCKPHRGRG PPKKRRPELE SDSENEAEVG PSKKERLREG
DNSGTSVALL ETPSQIPEAV WPHLSLQDFL DPVTWKDRAK MGQMPPYFDL IEENLYLTER
KKNKSHRDIK RMQCECAVLP KEERAQGAVA CGEDCLNRLL MIECSSRCPN GGYCSNRRFQ
RKQHAEFEVI LTDSKGWGLR AAKDLTPNTF VLEYCGEVLD HKEFKARVKE YARSKNIHYY
FMALKNNEII DATLKGNCSR FMNHSCEPNC ETQKVCKERA RLISFLTPFD FCLNWQIFSG
GQ
//
