ID W5LXB8_LEPOC Unreviewed; 2430 AA.
AC W5LXB8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=APC regulator of WNT signaling pathway 2 {ECO:0000313|Ensembl:ENSLOCP00000000775.1};
GN Name=APC2 {ECO:0000313|Ensembl:ENSLOCP00000000775.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000000775.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000000775.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the adenomatous polyposis coli (APC) family.
CC {ECO:0000256|ARBA:ARBA00009051}.
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DR EMBL; AHAT01011289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01011290; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01011291; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01011292; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 7918.ENSLOCP00000000775; -.
DR Ensembl; ENSLOCT00000000779.1; ENSLOCP00000000775.1; ENSLOCG00000000661.1.
DR eggNOG; KOG2122; Eukaryota.
DR GeneTree; ENSGT00530000063749; -.
DR HOGENOM; CLU_001012_0_0_1; -.
DR InParanoid; W5LXB8; -.
DR OMA; FRQMTHS; -.
DR Proteomes; UP000018468; Linkage group LG19.
DR Bgee; ENSLOCG00000000661; Expressed in camera-type eye and 4 other cell types or tissues.
DR GO; GO:0030877; C:beta-catenin destruction complex; IBA:GO_Central.
DR GO; GO:0016342; C:catenin complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0008013; F:beta-catenin binding; IBA:GO_Central.
DR GO; GO:0045295; F:gamma-catenin binding; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0001708; P:cell fate specification; IBA:GO_Central.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0007026; P:negative regulation of microtubule depolymerization; IBA:GO_Central.
DR GO; GO:0007399; P:nervous system development; IBA:GO_Central.
DR GO; GO:0007389; P:pattern specification process; IBA:GO_Central.
DR GO; GO:0045732; P:positive regulation of protein catabolic process; IBA:GO_Central.
DR GO; GO:0045595; P:regulation of cell differentiation; IBA:GO_Central.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.10; -; 1.
DR Gene3D; 1.10.287.450; Helix hairpin bin; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR009234; APC_basic_dom.
DR InterPro; IPR026831; APC_dom.
DR InterPro; IPR026818; Apc_fam.
DR InterPro; IPR032038; APC_N.
DR InterPro; IPR036149; APC_N_sf.
DR InterPro; IPR041257; APC_rep.
DR InterPro; IPR009223; APC_rpt.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR009224; SAMP.
DR PANTHER; PTHR12607:SF3; ADENOMATOUS POLYPOSIS COLI PROTEIN 2; 1.
DR PANTHER; PTHR12607; ADENOMATOUS POLYPOSIS COLI PROTEIN FAMILY; 1.
DR Pfam; PF05956; APC_basic; 1.
DR Pfam; PF16689; APC_N_CC; 1.
DR Pfam; PF05923; APC_r; 1.
DR Pfam; PF18797; APC_rep; 1.
DR Pfam; PF00514; Arm; 2.
DR Pfam; PF16629; Arm_APC_u3; 1.
DR Pfam; PF05924; SAMP; 2.
DR Pfam; PF11414; Suppressor_APC; 1.
DR SMART; SM00185; ARM; 7.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF58050; N-terminal coiled coil domain from apc; 1.
DR SUPFAM; SSF82931; Tumor suppressor gene product Apc; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 6..57
FT /note="Adenomatous polyposis coli N-terminal dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16689"
FT REPEAT 626..668
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT DOMAIN 1900..2255
FT /note="Adenomatous polyposis coli protein basic"
FT /evidence="ECO:0000259|Pfam:PF05956"
FT REGION 97..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 805..836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 931..966
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 978..1037
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1129..1153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1255..1292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1471..1493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1567..1620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1760..1808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1829..2082
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2122..2148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2165..2284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2304..2332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2348..2368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2405..2430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 8..59
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 810..836
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 931..961
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 978..1002
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1129..1146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1255..1281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1476..1493
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1764..1782
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1783..1808
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1829..1857
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1858..1877
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1912..1949
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1960..2036
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2043..2082
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2122..2139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2173..2197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2205..2219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2237..2261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2262..2284
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2313..2328
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2405..2419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2430 AA; 268493 MW; BF09831CFD5A3994 CRC64;
MAGSVASYDQ LVRQVEALRK ENTHLRRELE DNSNHLSKLE NETSDMKEVL KQLQCKLEQE
ARTLASTGRT DVLDQLKELH MDLTNYYELK YQPHNLRGSQ AAQAAEEEDR TPAPSSDLKT
GTSGEGRVTA QHLEDLCKER TLLLSEIEKE ERERRWYYSQ LQGLSQRLAE LPRVETFSMQ
MDLIRQQLEF EAQQLRSVME ERFGTSDEMV QRTQQLLPSP ALCLRSSRAE SSELQLLGLH
GDRKGGKTHS CGKLSIPESE NTACCAISEA PSDTGSKVEM VFWLLSMLAT RDREEMSRTL
LTMSSSQESC VAMRKSGCVP LLVQILHDGP GAGAGGGCSR EARARASAAL HNIVYSQPDE
GQARREMRVL HVLEQIRAHC EGGWDWVETH RSPAGQEGSS ATATPEPVEP QICQAMCAIM
KLSFEEEYRR AMNELGGLQA VAELVQLDQE LYGTLSEPLS LALRRYAGMA LTNLTFGDVV
NKAALCSKKS CLQAIVAQLA SDSEELHQVV SSILRNLSWR ADINSKKILR EVGSVTALTT
CALQATKEST LKSLLSALWN LSAHSTENKV AICSVDGALG FLVSTLTYKC QSNSLAIIES
GGGILRNVSS LVATRDDYRQ ILRDHNCLQT LLQHLRSHSL TIVSNACGTL WNLSARSPKD
QELLWDLGAV SMLRNLIHSK HKMIAMGSAA ALRNLLTNRP PKYKDAAVVS PGSCMPSLYM
RKQKALEAEL DAKHLAETFD SIEKQQSPKL QSINKPLRHI ESLAKDYASD SGCFDDDEAP
NVSTSLDTGS FSMLSMFLNS SNFLQGQSRK KGSEPERDVD PQAEDGKKPQ PADDDVSVAA
EKLAKKITTT VAKIDKLVED ITMHTSSEDS FSLSSEDHFV DWQYGSDELH EARAKSCSPC
RLSDTSSFAR RERLSRAHAL LRLKTAHTSL STDSLNSGST SDGYSGSKDQ IRPSARSATV
QRRPNRLELK VAQQGYLDKH DHCIPAETNP NDVAEKDSED RTNMSLPNQS STDAEDQCKE
PPPPTPATEP TKLSSETNVP TIKLSPSYQH VPLIGSVAKF GIPRNPINSQ GMRRQAWIPA
INSGGIMKQP PVIQARSPTL SQLETLQKYS VENTPICFSR CSSLSSLSSA DGALDGQSQS
ENELESDSSV EIIDVEDCDL EKNEEESLED LSESSPTSQP IEIPCHIKRE KVFLRGVSPG
RHEDMTPSSS SENYIHETPL VMSRCSSVSS LGSFESPSIA SSIQSDPCSE MISGTISPSD
LPDSPGQTMP PSRSKTPCYA DASGQDAQAG GGQWESNLRK LMEIADFKER FNLPPDLDTM
IYFTVEKPTE NFSCASSLSA LPLHEHYIQK DVELKLMPLL HEKDNSPFNT AHGQREETGE
EHPLLGAENQ ADRYGEGNSD DDIEILKECI NSAMPSKFRK VRTSLMSSLS TQVLSSQTRR
SMQLPVYMLL PAQTNQMGSM RKTARPDKDF YQDDSSFTDS AEGTPVNLSS TTSLSDETLQ
YPVKEEKGLK DWQLRRMEKQ DMMALEAKRI EDLRSFSHFH KPTKMAGHAE MVTNQMNRVI
KTVLPTQGVQ MHSREAKASL SQLRSRDQSP SHMIQRQDQS HPRNLPKKQS AGMHQGQNNY
GEYVHGNLAF QSMRHTTPTE EAIYCFYDDQ MEAKREGGRK ASTGRKQIKE ANRNILTHAA
ASADRTINLQ SKQKCITNKL KHNLIMDETP PCYSLSSSLS SLSDADLEEH QGKAQQVWVK
NSSSSSVSLD SEDDLLQKCI TSAMPKQRRR HSARKRKSEK KQKLKKAVEG WNPARDQESD
NMASDKDSDL NSIEWRAIQE GAHSIVTRLQ AASKSREPSS ESESVLSCMS GVSSFHTNQE
KSDKKKNVKE QGKGNKMPDG RNPRTQLDFA QRKPVPNLPV VFRGRTVIYM PNPKKETNSS
QKPPLKKTSP KTETPVKNPN LAQQRSRSLH RLGRANDSTE LSLPKRSSTP PARIPKSTSS
GSSQNSTPSR QPQKKLTSPS QSSKQIPKKD VKPTNSPTDK KTSPAASPSP KSPAHKKTQK
SPVRIPFMQT PSRQPMASRT ISPLVTNQPS PGISRQNTQL KRTLPANRLD LVRMSSTRSS
SSESDRAGFL RQLTFIKESP SLLRQRSEIP SSRSVPTSKC ASPRKMRPGA PAAFLCSSRC
QELKGVGQGP RETQDEGQGQ GAQRQRAALS RASSSDRGLS GVRPARRTSS ESPCRAPQKN
ISGAWQRERD TFKRHSSSPH INILKRATSR SSILSSSSES SGKVKSEEDR KTQKQQEPRG
RGKITWRRIR DEDVPHILKS TLPSTALPLV PSPEGQKPMP PLPGKLPTIT LPPRKTSDAT
VQTEDFATNK TNSSTSPTIE RAGESQTTPC ASHAIEGHNG GIGHFRQSSP SKAVRVTPFN
YIPSPMACGS QSTQIRAPTL NEKPGERLEA
//
