ID W5M0P3_LEPOC Unreviewed; 4590 AA.
AC W5M0P3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Sacsin molecular chaperone {ECO:0000313|Ensembl:ENSLOCP00000001950.1};
GN Name=SACS {ECO:0000313|Ensembl:ENSLOCP00000001950.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000001950.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000001950.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AHAT01003338; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01003339; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01003340; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01003341; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 7918.ENSLOCP00000001950; -.
DR Ensembl; ENSLOCT00000001955.1; ENSLOCP00000001950.1; ENSLOCG00000001682.1.
DR eggNOG; ENOG502QQPY; Eukaryota.
DR GeneTree; ENSGT00390000016695; -.
DR InParanoid; W5M0P3; -.
DR OMA; IKLHSQY; -.
DR Proteomes; UP000018468; Linkage group LG3.
DR Bgee; ENSLOCG00000001682; Expressed in zone of skin and 8 other cell types or tissues.
DR GO; GO:0030544; F:Hsp70 protein binding; IBA:GO_Central.
DR CDD; cd17049; Ubl_Sacsin; 1.
DR Gene3D; 1.10.287.110; DnaJ domain; 1.
DR Gene3D; 1.20.120.330; Nucleotidyltransferases domain 2; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR007842; HEPN_dom.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR15600; SACSIN; 1.
DR PANTHER; PTHR15600:SF42; SACSIN; 1.
DR Pfam; PF05168; HEPN; 1.
DR SMART; SM00748; HEPN; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 3.
DR SUPFAM; SSF46565; Chaperone J-domain; 1.
DR SUPFAM; SSF81593; Nucleotidyltransferase substrate binding subunit/domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
DR PROSITE; PS50910; HEPN; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT DOMAIN 25..86
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000259|PROSITE:PS50053"
FT DOMAIN 4317..4392
FT /note="J"
FT /evidence="ECO:0000259|PROSITE:PS50076"
FT DOMAIN 4462..4578
FT /note="HEPN"
FT /evidence="ECO:0000259|PROSITE:PS50910"
FT REGION 4262..4307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 4356..4383
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 4275..4289
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4590 AA; 520385 MW; D6A00B49C6BA7109 CRC64;
PSMCGQPFQL PRVTVLHEYI GHRVFEVPLS AAVEDVKQLI CTDTDFPISE QQLFHNGKEL
HGDIRLGNLL LPGSYEVFMT LRGRGLKGGG RFGQTTPPLV EFLKDILRRY PEGGQILKEL
IQNAEDAGAS EVKFMYDEME YGQESLWSDD MAQYQGPALY AYNNAVFTAE DWNGIQEIAR
SRKREDPLKV GRFGIGFNSV YHITDVPSIF SGDQIGILDP HQALFGPHES GQCWNLKSDV
KEIDEHADQF APYVGLFGIS EKTIKDGGFP GTLFRFPLRI KPSQLSSNIY NKEKVLELFE
SFKADADTVL LFLKSVQVVS LHVRESDGTE RMLFRVTASE NPELKLERPS SLKTLGLAID
SYSNGLPSGS ITCATYQLNI EMEDETAKEV QRTSWLVCNS VGGRGMCNEL DCLADDLRFI
PTIGIAMPLT ATDEDKGAAS GFLGRAFCFL PLPPGEESTT GLPVHVSGFF GLTDNRRSIK
WREVDQWRDP AALWNELLVA HMVPRAYATL LLEAIKRIQT AKDQDFSLSP EGVYKAWPDL
GQIRARWKPI LAPLFKALLQ QPVIFSASKC WLKVEEVFFS ELDDGADGTE AVLSFLQGAG
LQVARAPASV AAALAAFAAE PGAVRKVTPA LARQVLRKSR PRVPAPERQQ LLEFVLSDAC
YGELIGLELL PLQDETCVAF SSSASDKDAV YIATEDYPRS LFPGLEGRFL SESIKPSVMR
VLVEAAKSRV QQLLWGCTGR PCTQLQILTP ERSARLIKEI LTTVWPSRDA SVPWSPGNQE
KNHPSVSWLK MVWKYLYINF PEDLSTFEDM PLIPNVPLED TVTSLELLRL KTPSPIILES
EEESPLPEHL PEIIKKLGGI IIQKLDSSLQ HPLLHKYIHP PTACSVLQIM DRSSTQRVAS
QVTAFPAKYK VALRSFLARL PDVNEKEMRI LQELMIFEKI GPLDEKGTPA FTVLKGAKAL
QHAAKLPPNI RLSVNVIDNS DEAAVRLIKM LNVEQLKSTD CLKLIIQDIE KGFYSKEEIT
EIMLWVLKHL SFLKNENPAV IQWLSSLKFI QTAHGKLVAA TELFDPELEI LQSLFYTEEK
IRFPPSTFTS SPDILHSLRQ LGLKNEVQLS EKDVLQVARK IEDLQRTVRS EWGPLLEKAK
TLLTILTKQT KLVKSSEIQV SLQKLKWVPV CKDRPLNYPH SLEWKGDNLN ISSLCEMCDI
SQAVLVGSSV ALVERISAGM KKALKLSIEP QVDQVLQHLK AVVDWHRSQA FTTEDWYQFQ
QILLEIYEFM QEHLESAREV IKSLPFAWVW TGKTFSSPVQ TVLKPIPDLD LQPYLYSLPK
TIAKFHKLFQ FCGSVEQVIP EHVFEVISII KECSEREMTK EESKQNLLLL LNILRWLYSN
QISVALDTPV PILYIKDPHR LVMKPIHECS YCDIKVDDLN DLLDDVSEPI ILVHDDIPMK
TAEWLKVPCL STRLINPENL GFEQSGQREP LTVRIKNILE EYPSVSDIFK ELLQNADDAG
ATECSFLIDM RKNLDIRENL LDPGMSVCHG PSLWSFNNSV FSDSDFVNIT RLGGSMKRCE
ADKVGKFGLG FNSVYHVTDI PIIMSREFMI MFDPNINHLS KHIRDRSNPG IKINWSKQQK
RLRKFPNQFK PFINVFNCKL PLSQELPYKY NGTLFRLPFR TEQEASVSEI SGLYYNTTDI
YSLVDEFSIC GHRLILFTQY VGSMVLKYLK YEEPNPAGSQ DVVTINKCVW SSKATYGPVS
ILKAAAKVMK KVANTNRVPS DIPRSACIIR IVVEEFHNVF RRIVDLQSPL FRGPEDDPSS
YFELAAKGSQ AKRGSEEVPQ KAVDITNWLI CSCMDVGEAL KFSLNESGRR LGLVPCGGVA
VLLAEKDDHV WTVKTNPTPI GEVFCYLPLR IKTGLPVHIN GCFAVTSNRK EIWKTDTKGR
WNSIFMRHVI VQAYLEALNT LRVMAINGEL VNYNYYAAWP DPSLVHDDFA LVSQGVYQEI
AKGGDRDLAK VFSDGKNYVS IKYVRFLDDS LLCRPDIGPA AFKIFLKYLR KSGSQDLCAV
ELPYWVKEGF EDAGCKGMLM ENTLTEKQFF SDVFFPHIQD IEKELRDPLM YYVLNEKVEE
FAAILKVTPC IPCSGKSNQL VVPSRVIHPE GRVAKLYDTS DGRFPQGTSS DYLNPVVLVK
LVQLGMVKDD ISWEDLIERA ESVAALNESD HTAACVRGST LLSLVDEKLK IRDPRAGEFK
EKIQNIRFLP FLTKPAGFSL PWHGNNFPPS TMFTATDLYT TEHQDTVCLM KPILNENSPS
FKGCGPITLA VKDFLGLIKK PTVELVMNQL KELSKSFDGV TLYQENITNA CYKFLHEEML
QNDDAKEKIM QELKNFCSIL VENTYIDPAK VAFHLNFDAA PYLYQLPNKY RNTFRELFEN
VGVQPSFTVK NFAAVLEAVK KECGRKPLSE DSFQLCRRIV SEGIWGLIRD KSQEFCQSTY
GEILLPDSHS SLQPSKSLCY NDCPWIKVRD TTVKYCHADI PREVAVKLGA IPKRHKALER
YASNICFTTL GSEFGQKEKL TSRIKSILNA YPSEKEMLKE LLQNADDAKA TEIYFVFDPR
SHPTDRIFDD KWVPMQGPAL CVYNNQPFTE DDIRGIQNLG RGTKEGNPGK TGQYGIGFNS
VYHITDCPSF ISNNDILCIF DPHARYAPGS TSVSPGRMFR DLDSDFRTQF SDVLNLYLGE
RFKLDRCTMF RFPIRTADMA KVSEISSVPA SDRMVQNLLE KLKADGAELL MFLNHMEKIS
ICEVEKGTGE LKVLYSVTAK ITDGDRLKRK QFHASVVDSV AKKKPLTQIP VQQITYTMDI
EDSDGNLMTW LVCNRSGFSN TQKVSKSVIS AHKNEDITLF PRGGVAACIS HNYKKPHRAF
CFLPLSLETG LPFHVNGHFA LDSARRNLWR DDNGVGVRSD WNNNLMTALI APAYVELLIQ
LKRRFFPGSD PTLTVLQGTA IHIVKDTLRK FLFFFPVNRL DIQPDWYCLV KAVYSCIHAD
LKRLLPVVRA PHIDNTDLHA AIYISWVNTS TAPKGQAFFD NLLQDELQHL KNTEYNITTR
KTIAENVYRL KALLLDVGFN LVHNCDETAS LYYCLEDAGI PVSYVTPADV RSFLLTFSSP
DSNCQVGKLP CRLQQSNFKL FHSLKLLVDY CFKDAEETEI KIEGLPLLIT MDNILQVFDS
KRPKFLTTHH DLIPSRKELF MNTLYMKYSN ILLKSDVAKV FDISSLGDLL GSVLPREYRT
RAVVKWKDNY ASESWLKNVW HFISDNVCIK EEQSDLKPKF ETVLDILKDW ALLPGTKFMV
SSNMLVVPEC DVLLPLSLIY AAIFPNGQND KVFHTLMKAG CIQLALNKIC TKENPVVPFL
AHHTANIDNP SSILKALEYM IQTSAFNTGG LKNNDFEALL LYFNCNLINL SQEDVHSLKL
LPCYKSVSGR YINISKFGSC FVLTKSIPSA DMEKWAQSTS SAFLVDNPQL RELYGFLGCV
PVDDLEVYLK HLLPKFDSLS YDAKIEHLIY LKDRLLSMED YSVIKDQLYE KLESLSFIYD
STRRLKPAKT FFDRTVKVFE VMLPEKAFIP NEFFKKIELV SKPKNGTSFL ATWISFLRNV
GLKHVISQQQ VLQFAKEVSI KAQTENWSKE KTQNVVDVLL NHIFNERTDL FLGTFIKELS
MIPFLCPERA TAELLRLHAQ YQEINGTLPL IRFNGSQVNP KFKQADVMQL LWTSCPVLPE
KATPASIKEQ EGSTLSAQEQ LDQVLTMLNV NMDPPLDKVI SNCKNICSIP NLDDDMVKTR
VKVLRSTYEF LNADKRDFRF QLRGVAFVMV EDGWKLLKPE EVVINLENES DFKPYLYKLP
LELGTFHQLF KLLGTEDIVS TKQYVEVLCR IFRNSEGKQL DPNEMRTVKR AVSGLFKSLQ
NEPVQVRQDL EILRDLTFYL PSHDGRLAKS NTLVFDDAPH YKSRIQGNIG VQMLVDLSQC
YLGKDHAFHT KMIMLLPQKL RPRLLSSILE EQLDEETPKM CQFGALCSLQ GRLQLLLSSE
QFITGLIRIM KHENDNAFLV NEEKAIRLCK ALCEGLKVSC FEKLQTTLRV KGCSPIPQSR
CETLAFLKRY GTAVIHLYIQ HSDSKDINFL LALAMTLKSA TDNLISDTSY LIAMLGCNDI
YRITEKLDNL GVKYDSTEPS KLELPLPGTP IPAEIHHILL MDPMNVFYPG EYVGYLVDSE
GGDVYGSYQP TYTYAIIVQE VEREEEENPS FLGKLFQIDI GYSEYKIVSS LDLYKFSRQD
ESSHIRDSAP STPTSPSECP SPGPRMVPPL FPGKESHRAA PSKQSPHKLK LNALPDILKE
VTSVIEQAWK LPESERKKTI RRLYLKWHPD KNAENLEIAT EVFKHLQNEI SRLEKQSLAE
QAADRASRRP FSTSSTRFQS EAKFSFQRFY TSWNQEATSH KSEKQQFREQ FTSYSGSSHS
PRFFVPPTFK SVGNPVEARR WLRQARANFS AARNDLHKNA NEWVCFKCYL ATKLALIAAD
YAVRGKSDKD VKPAALAQKV EEYHEQLVGL ANDVHILEAY GVDSLRTRYP DLLPFPQIPN
DRYTSEVAMR VMECTARVII KLENFVQQKI
//
