ID W5M1T7_LEPOC Unreviewed; 339 AA.
AC W5M1T7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=X-ray repair cross complementing 4 {ECO:0000313|Ensembl:ENSLOCP00000002345.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000002345.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000002345.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the XRCC4-XLF family. XRCC4 subfamily.
CC {ECO:0000256|ARBA:ARBA00025728}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AHAT01023484; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01023485; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01023486; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01023487; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01023488; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01023489; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01023490; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01023491; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01023492; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015216180.1; XM_015360694.1.
DR RefSeq; XP_015216185.1; XM_015360699.1.
DR AlphaFoldDB; W5M1T7; -.
DR STRING; 7918.ENSLOCP00000002345; -.
DR Ensembl; ENSLOCT00000002350.1; ENSLOCP00000002345.1; ENSLOCG00000002026.1.
DR GeneID; 102689368; -.
DR CTD; 7518; -.
DR eggNOG; ENOG502QWJA; Eukaryota.
DR GeneTree; ENSGT00940000166544; -.
DR HOGENOM; CLU_072334_0_0_1; -.
DR InParanoid; W5M1T7; -.
DR OMA; MQKDISF; -.
DR OrthoDB; 3672339at2759; -.
DR Proteomes; UP000018468; Linkage group LG2.
DR Bgee; ENSLOCG00000002026; Expressed in bone element and 13 other cell types or tissues.
DR GO; GO:0032807; C:DNA ligase IV complex; IBA:GO_Central.
DR GO; GO:0005958; C:DNA-dependent protein kinase-DNA ligase 4 complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0051103; P:DNA ligation involved in DNA repair; IBA:GO_Central.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IBA:GO_Central.
DR GO; GO:0033152; P:immunoglobulin V(D)J recombination; IBA:GO_Central.
DR GO; GO:0010165; P:response to X-ray; IBA:GO_Central.
DR CDD; cd22283; HD_XRCC4_N; 1.
DR Gene3D; 1.20.5.370; -; 1.
DR Gene3D; 2.170.210.10; DNA double-strand break repair and VJ recombination XRCC4, N-terminal; 1.
DR InterPro; IPR010585; DNA_repair_prot_XRCC4.
DR InterPro; IPR014751; XRCC4-like_C.
DR InterPro; IPR038051; XRCC4-like_N_sf.
DR InterPro; IPR009089; XRCC4_N_sf.
DR PANTHER; PTHR28559; DNA REPAIR PROTEIN XRCC4; 1.
DR PANTHER; PTHR28559:SF1; DNA REPAIR PROTEIN XRCC4; 1.
DR Pfam; PF06632; XRCC4; 1.
DR SUPFAM; SSF58022; XRCC4, C-terminal oligomerization domain; 1.
DR SUPFAM; SSF50809; XRCC4, N-terminal domain; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT REGION 208..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..233
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..308
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..330
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 339 AA; 37996 MW; A31987050B24B162 CRC64;
MGTSVRRISI SSEPGKIFFL RVKRGEDLGS GFSVVLCDGQ SAWSGAVSEE EVSREAKEME
MKRENYVKDL SQALLTERSQ EPVRYSFHVS RDGLETGALL LSYDKVQKEI SFKLGSVELH
AVAEPIEVIK ELISHGLEHS TELQARNQHL QEENEKLRRE WEYVTGELEK YVQAKETLEG
DLYTRFALVL NEKKAKIRSL QQKLNHLQGD MESVNVPRRD TATVERKNPE EPDYEGTTDE
ENEENNACSQ SSASARDKPG LSSLDVSLND TIDVAPSRKR RQRHVRGQES DAKKGSKEGQ
EKGRVESAPK TSDVSNEAPQ GSTNTASSAP EPEDLFDDI
//
