UniProt: W5M3H3

Database: UniProt
Entry: W5M3H3_LEPOC

LinkDB:  W5M3H3_LEPOC 
Original site:  W5M3H3_LEPOC

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Ontology (10)   
   GO (10)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (3)   
   ENSEMBL-UP (3)   
DNA sequence (3)   
   EMBL (3)   
Protein domain (16)   
   InterPro (9)   
   Pfam (3)   
   PROSITE (3)   
   SMART (1)   
All databases (33)   

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ID   W5M3H3_LEPOC            Unreviewed;      1043 AA.
AC   W5M3H3;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   RecName: Full=Guanylate cyclase {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE            EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
OS   Lepisosteus oculatus (Spotted gar).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC   Lepisosteus.
OX   NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000002931.1, ECO:0000313|Proteomes:UP000018468};
RN   [1] {ECO:0000313|Proteomes:UP000018468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT   "The Draft Genome of Lepisosteus oculatus.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLOCP00000002931.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC         Evidence={ECO:0000256|RuleBase:RU003431};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC       family. {ECO:0000256|RuleBase:RU000405}.
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DR   EMBL; AHAT01020470; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01020471; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01020472; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; W5M3H3; -.
DR   STRING; 7918.ENSLOCP00000002931; -.
DR   Ensembl; ENSLOCT00000002937.1; ENSLOCP00000002931.1; ENSLOCG00000002488.1.
DR   eggNOG; KOG1023; Eukaryota.
DR   GeneTree; ENSGT00940000156223; -.
DR   HOGENOM; CLU_001072_1_3_1; -.
DR   InParanoid; W5M3H3; -.
DR   OMA; FGPFTKM; -.
DR   Proteomes; UP000018468; Linkage group LG4.
DR   Bgee; ENSLOCG00000002488; Expressed in testis and 2 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004016; F:adenylate cyclase activity; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004383; F:guanylate cyclase activity; IBA:GO_Central.
DR   GO; GO:0016941; F:natriuretic peptide receptor activity; IBA:GO_Central.
DR   GO; GO:0017046; F:peptide hormone binding; IBA:GO_Central.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0006182; P:cGMP biosynthetic process; IBA:GO_Central.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0007168; P:receptor guanylyl cyclase signaling pathway; IBA:GO_Central.
DR   CDD; cd07302; CHD; 1.
DR   CDD; cd06352; PBP1_NPR_GC-like; 1.
DR   CDD; cd12087; TM_EGFR-like; 1.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR018297; A/G_cyclase_CS.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR001170; ANPR/GUC.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   PANTHER; PTHR11920:SF464; GUANYLATE CYCLASE; 1.
DR   PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   PRINTS; PR00255; NATPEPTIDER.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   3: Inferred from homology;
KW   cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW   ECO:0000256|RuleBase:RU003431};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        451..472
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          505..785
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          856..986
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   1043 AA;  118107 MW;  854A5F550F76CA98 CRC64;
     LDFKLLISMP NTSSQFHVGR IGAGALIAID EINRNSILLK VYLLGHRLVY EYVDDECDAI
     RGPGKIVSLQ HNQNYSAFIG PSCSKVCSHV GRLAGYWNIA VVSPICADSE FLDKKEFPTM
     TRVFGPFTKM GSFFVKICEK FNWRRIGIIY DTSPTWTIPA GGIRLYYTVQ GLVNSDTGSF
     HHFSSIGQRA MRNEIELSHQ LSVKHINIRH NSSLLAKCMQ IKYLNDILIN AHNQGLINGE
     YVFFCFEPYE QKQRCKAGGG AVSGCKLQRR DAYDSIAREA YQALFLLTLY KPDNERYMNF
     SAEVIRRSKE DFGYQYEPGE KVSVLPAIAH DSVWLYAHAL NETISENGDP YNGTAISRKM
     WNRTITGIQG EVTIDDNGDR ESSYMMYHVQ NKSNGTFQVI ANYFGTRKNY EQVPGLSIVW
     PGGRSTPPLD TPVCGFTEEM CEDDSKARTT IIAVGLIGGL LAVVIVGLSL LYRKYKLQEK
     ASLMLWKVNF SEVSMMETKH NSSVYKKLEI FLRGYTYKAI SESENTQSDF LFTKAAMYKE
     NICSIRFLHV KSINLNNELI NELRQCRDLN HPNVCSFIGA CLESPHHCLL TEYCPKGSLQ
     DILKNDSIKL DWMFKYSLML DIVKGMDYIH KSYLRSHGHL SSSNCVVDSR FVLKITDFGL
     SNLRRPNTAG IQNSKEHWQC LLWRAPELLR GNMPTNGTQK GDVYSFGIIA QEIVYRNGVF
     FIPSCVLKAN EIIEKVKEGG SNSFRPYTDT TECPGPLAML MKSCWRERPS ERPDFTSLKA
     TVKKLDRGSD NILDNLLSRM EQYASNLEDI VNERTAQLLE EKKKAESLLT QMLPRSVAIQ
     LISGKTVQAE TYDCVTIYFS DIVGFTAMSA GITPMQVVDL LNDLYTYFDN IIDNHDVYKV
     ETIGDAYMVV SGLPIRNGDE HAKEIARMSL SIVDAMKKFE NRHVPGQQLK VRIGLHSGPC
     VAGVVGLKMP RYCLFGDTVN TASRMESYGL PLKVHVSSSA KDLLDKFRTF RFELRGDIHM
     KGKGLVRTFW LLGEETKRHW NDI
//

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