ID W5M4X3_LEPOC Unreviewed; 596 AA.
AC W5M4X3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=E3 ubiquitin-protein ligase TRIM39-like {ECO:0000313|Ensembl:ENSLOCP00000003431.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000003431.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000003431.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AHAT01038764; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015201614.1; XM_015346128.1.
DR AlphaFoldDB; W5M4X3; -.
DR STRING; 7918.ENSLOCP00000003431; -.
DR Ensembl; ENSLOCT00000003438.1; ENSLOCP00000003431.1; ENSLOCG00000002915.1.
DR GeneID; 102683306; -.
DR KEGG; loc:102683306; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT01040000240385; -.
DR InParanoid; W5M4X3; -.
DR OMA; LVEETIM; -.
DR OrthoDB; 1116590at2759; -.
DR Proteomes; UP000018468; Linkage group LG5.
DR Bgee; ENSLOCG00000002915; Expressed in pharyngeal gill and 3 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0002376; P:immune system process; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR CDD; cd19769; Bbox2_TRIM16-like; 1.
DR CDD; cd13733; SPRY_PRY_C-I_1; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 4.10.830.40; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR25465; B-BOX DOMAIN CONTAINING; 1.
DR PANTHER; PTHR25465:SF34; TRIPARTITE MOTIF-CONTAINING 80; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT TRANSMEM 370..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 15..55
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 144..184
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 396..592
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT COILED 253..294
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 596 AA; 67197 MW; BF1B61A924049562 CRC64;
MISPGSLLSE EQLLCSICLD VFASPVSLPC GHNFCQACIG GYWDSGGACQ CPLCKEAFGR
RPSLQINRTL NEIAEQFKAT RSSRADGGAA GPGEVPCDVC AAEKLRAVKS CLVCLASYCD
EHVQPHREVG RLSRHRLVDP ARSLRDKLCR KHGRQLELFC RRDQAFICRL CTKKDHRTHS
TVPIEAQRLE LQNNMRKTQA HLQQMAQDRL KKVEDVKKSV KLHKRWVQKE MKDSVKLCTA
LAHCVERSQA EVIKALEDKQ RAAEVQAEGL IKELEQEMAA IKRRNAELEQ LARTEDHLLF
LQCFPSLCSP PQTKEWSSIT LPTEPSADSS WEALTHLEER FLEELRKLKN KGPQDNPARR
RSSCSWRTMV LSYMWTVILT AVLLGFYAHT HMQKQTPQDE MRNAQISSTS VRMVNVTLDS
STAHPSLILS EDGKQVRLGD APQDLPDNPE RFDQDFCVLG AEGFTSGRHY WEVEVGDKTE
WDLGVARESV DRKGEITLSP EDGYWSIWLK NGKEYQALTD NAVALPLSTR PRKVGVYVDY
EGGQVSFYNV EASSHIYTFM ASFTEKLYPY FSPGLNSDGK NSAPLIISSP AHIKNK
//
