ID W5M6M8_LEPOC Unreviewed; 2089 AA.
AC W5M6M8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Dedicator of cytokinesis 9 {ECO:0000313|Ensembl:ENSLOCP00000004036.1};
GN Name=DOCK9 {ECO:0000313|Ensembl:ENSLOCP00000004036.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000004036.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000004036.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR EMBL; AHAT01025034; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01025035; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01025036; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01025037; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSLOCT00000004044.1; ENSLOCP00000004036.1; ENSLOCG00000003216.1.
DR GeneTree; ENSGT00940000155972; -.
DR Proteomes; UP000018468; Linkage group LG17.
DR Bgee; ENSLOCG00000003216; Expressed in camera-type eye and 13 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR CDD; cd11698; DHR2_DOCK9; 1.
DR CDD; cd13267; PH_DOCK-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF77; DEDICATOR OF CYTOKINESIS PROTEIN 9; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT DOMAIN 169..276
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 633..811
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1621..2050
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 286..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1193..1212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1249..1277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..301
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2089 AA; 237379 MW; A44FA1EC7D61835B CRC64;
MQGRANKTSK KELVIESPKQ YKNVTSPEAE VETVVQVVAK PKVIEPIDYE TVLVQRKTQI
LSDALRDMLQ FPLEDFQISI LRRSGRTIYP TVPENAEKEA QSLFVQECIK TCNSDWHVVN
YKYEDYSGDF RQLPNKVSRP DKLPVHVFEV DEDVDKDEDT ASLGSQKGGV TKHGWLYKGN
MNSAISVTMR SFKRRYFHLT QLGDGSYNLN FYKDEKLARE PKGSIFLDSC MGVVQNNKVR
RFAFELKMQD KSTYLLAADS EVEMEEWIST LNKILHSSFE LAMQEKRNGE THEDDDQGKA
DSSSASLDSF QSGRDIESKT RSETRLKLFT LDPDTQKLDF SGIEPDTKPF EEKFGKRILV
NCNDLSFNLQ SCVAENEEGP TTNVEPFFVT LSLFDVQNSR KISADFHVDL NHPSVRHMLS
NPSSQYMNGG GEAVLGPQRM FNGLAESMLQ YPKQGIFSVT CPHPDIFLVA RIEKVLQGGI
THCAEPYMKS SDSAKAAQKV LKNAKVACSR LGQYRMPFAW AARSVFKDAS GTLDKSSRFS
AIYRQDSNKL SNEDMLKLLA DFRKPEKMSK LPVILGNLDI TIDSVAPDIT NGVTSSYIPV
KPFENNGKAN VFFEVEEFVP CIAKCSQPFT TYNNHLYVYP KHLKYDSQKS FAKARNIAVC
IEFKDSDEED AQALKCIYNR PGGPLFVKNI FAAVLHHQQN PEFYDEIKIE LPTQLHEKHH
LLFTFYHVSC DSTSKGSTKK KDVIETQVGF GWLPLLKDGR VIMNEQQILV SATLPAGYLS
CQEAGIGKHS GPEVKWVDGG KPLFKIATHL VSTVYTQDQH LHNFFHHCQS AQSVNQASGG
ELVKYLKSLH AMEGHVMVRF LPTILNQLFR VLTRATQEDV AVNVTSRVMI HIVSQCHEEG
LEHYLRSYVK YVFKIEPCAA TSTKTVHEEL AKAMTAILKP STDFLTSNKL LKYSWYFFEA
LVKSMAQYLI ESSKVKLSRN QRFSASFHHT VETLVNMLMP HITQKYKDNL DAARNANHSL
AVFIKRCFTF MDRGFVFKQI NNYVNCFVPG DPKTLYEFKF EFLRVVCNHE HYVPLNLPMP
FGKGRIQRFQ DLQLDYSLTD DFCRNHFLVG LLLREVGSAL QEFREIRQIA ISVLKGLMIK
HTFDDRYSSK SQQARLATLY FPLFSLLQEN VHRVNVKDVS PFAINHSNNN VRDDSLLGSA
MMTPQKPGSS LDNSLHKDVF GVISGTASPH ASSTPNINSV RHADSRGSLI STDSGSSLQE
KGSDKTNSLD KNQPASSLGS CVIRCDKLDQ AEIKSLLMCF LHVLKSMSED ALFTYWNKAS
STELMDFFTL VEVCLHQFRY MGKRYIARNQ EGVGPVAHER KSQTLPVSRN RAGMMHARLQ
QLSSLDNSYT FNHSYTHSDA DVLNQSLLEA NIATEVCLTV LDTLSIFIMG FKTQLCADHG
HNPLMKKVFE VLLCFLQINQ SEAALKQVFT SLRTFIYKFP CTFFDGRADM CASFCYEILK
CCNSKLSSIR SDAAHLLYFL MKSNFDYTGR KSFVRTHLQV VIAVSQLIAD VIGIGGTRFQ
QSLSIINNCA NSDKTVKNTA FPWDVKDLTK RIRTVLMATA QMKEHEKDPE MLVDLQYSLA
KSYASTPELR KTWLDSMARI HVKNGDLSEA AMCYIHVAAL VAEYLRRKGM FKQGCSAFRV
VTPNIEEEAS MMEDVGMQDV HFNEDVLMEL LEQCGDGLWK AERYEVIADI YKLIIPIYEK
RRDFEKLAHL YDTLHRAYSK VTEVMHTGKR LLGTFFRVAF FGQGFFEDED GKEYIYKEPK
FTPLSEISQR LLKLYSDKFG QENVKMIQDS GRINPKDLDS KYAYIQVTHV TPYLDEKELA
DRKTDFEKSH NIRRFVFEMP FTVSGKKQGG VDEQCKRRTI LTTTHSFPYV KKRIAVMYQH
QTDLNPIEVA IDEMSKKVAE LRQLCSASEV DMIRLQLKLQ GSVSVQVNAG PLAYARAFLD
DASSKRYPDN KVKQLKEVFR TRQFVEACGQ GLSINERLIK EDQLEYQEEM KANYREMARE
LSEIMHEQIS PVDDGVKSVL PDSLHIFNAI SGTPTSTTIQ GIPSSSSVV
//
