ID W5MBM1_LEPOC Unreviewed; 465 AA.
AC W5MBM1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Ankyrin repeat and SOCS box containing 18 {ECO:0000313|Ensembl:ENSLOCP00000005780.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000005780.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000005780.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; AHAT01011314; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015213765.1; XM_015358279.1.
DR AlphaFoldDB; W5MBM1; -.
DR STRING; 7918.ENSLOCP00000005780; -.
DR Ensembl; ENSLOCT00000005788.1; ENSLOCP00000005780.1; ENSLOCG00000004813.1.
DR GeneID; 102688187; -.
DR KEGG; loc:102688187; -.
DR CTD; 401036; -.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000158974; -.
DR InParanoid; W5MBM1; -.
DR OrthoDB; 1787271at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000018468; Linkage group LG12.
DR Bgee; ENSLOCG00000004813; Expressed in heart and 3 other cell types or tissues.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd03723; SOCS_ASB4_ASB18; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.750.20; SOCS box; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR24118:SF99; CHARON; 1.
DR PANTHER; PTHR24118; POTE ANKYRIN DOMAIN; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT REPEAT 150..182
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 217..249
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 250..290
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 291..323
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 413..456
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
SQ SEQUENCE 465 AA; 52085 MW; AE79A80697384195 CRC64;
MYSRRSSACA SYSSTLASLS GTKNDNGQST SMQSSGCLQA ALRESTVVRE PVRRAVRKPV
LLFECPPILR SLLTQHWKDL QDGYSDAEEL NKVIEFQSDE LQWTSKKYGL WSLEYKRELT
SPLCISAAQG YTDCLRYLLQ HGARPNLAPG GKTALHEACE NSNTACVELL LEHGASPVQL
NEEGLTPLHL CKTPQSFRCA KLLVRYGALV TQPSEEECET PLHVVAKRGL QNHAHLYLRY
GAEVNSTNSS GETPLGAACA RAQSLEEQDN YLQLCRLLLI YGADANVVDN EKRSPLHKAS
RNAQHGLVEL LLEHKADVNA IDYNGSSPLS NVLQNAVIKQ DLQPHLTVQT LLNHGSLKVW
PLAFLKVLTS CAGAPKTVEI LFNSYSQIPV TYKWIEAVQE DVYRTHQTFY ESLFSLENKP
RSLQHLCRFS IRKHYGKDCH LFIPLLRVPK FLQCYLLLDS EGIIY
//
