ID W5ME52_LEPOC Unreviewed; 565 AA.
AC W5ME52;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Mucolipin 3 {ECO:0000313|Ensembl:ENSLOCP00000006661.1};
GN Name=MCOLN3 {ECO:0000313|Ensembl:ENSLOCP00000006661.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000006661.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000006661.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AHAT01018370; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5ME52; -.
DR Ensembl; ENSLOCT00000006669.1; ENSLOCP00000006661.1; ENSLOCG00000005502.1.
DR GeneTree; ENSGT00950000183036; -.
DR HOGENOM; CLU_020945_1_1_1; -.
DR Proteomes; UP000018468; Linkage group LG10.
DR Bgee; ENSLOCG00000005502; Expressed in ovary and 4 other cell types or tissues.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR CDD; cd21072; ELD_TRPML3; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR049134; MCLN_ECD.
DR InterPro; IPR047317; MCOLN3_ELD.
DR InterPro; IPR039031; Mucolipin.
DR InterPro; IPR013122; PKD1_2_channel.
DR PANTHER; PTHR12127; MUCOLIPIN; 1.
DR PANTHER; PTHR12127:SF5; MUCOLIPIN-3; 1.
DR Pfam; PF21381; MCLN_ECD; 1.
DR Pfam; PF08016; PKD_channel; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 280..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 336..356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 408..430
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 476..497
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 86..266
FT /note="Mucolipin extracytosolic"
FT /evidence="ECO:0000259|Pfam:PF21381"
FT DOMAIN 367..504
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
SQ SEQUENCE 565 AA; 65191 MW; 3BD1F97F489C0421 CRC64;
MEDVGLSASY SSINDQSGNS FWAQNGEELD ADAVDNFRRK LKYFFMNPCE KFKARGRKPW
KLMLQILKIA IITIQLVSFG LSNQMVVAFK EENLMAFKHL FLKGYSDRPD ETYAVYTQSE
VYDHIYFAVN QYLNLHNLTV GNHAYEKLED VYTPLSVCQA FYKNGSIYPG NETFDIDPQI
ETACIEIYPL QPLGIGTLPS AFTLDFKRLL SVHINFTLKA INLQTVRLHE LPDCYDFTVT
ITFNNKAHSG KIKITLDNDV DINECRGWNI TGASPRNIHY LLAFDSFIIL ACVASFILCM
RSVINGINLQ LEYAVFFLTR YNKKVPWSER MEFVNGWYIL IIVSDTLTII GSILKIEIQT
KNLTSYDICS ILLGTSTMLV WIGVIRYLGF FQKYNILILT LRAAFPNVIR FCCCAAMIYL
GYCFCGWIVL GPYHNKFRTL NTVTECLFSL INGDDMFPTF SDMQQKSYLV WLFSRVYLYS
FISLFIYMVL SLFIALITDT YETIKQHQRD GFPESKLQEF IAECKDLPAS GRYRIEEDKL
SCFSSCWSRN SPSNQRSRQR SKQIS
//
