ID W5MFM7_LEPOC Unreviewed; 1162 AA.
AC W5MFM7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Plakophilin 4 {ECO:0000313|Ensembl:ENSLOCP00000007186.1};
GN Name=PKP4 {ECO:0000313|Ensembl:ENSLOCP00000007186.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000007186.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000007186.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the beta-catenin family.
CC {ECO:0000256|ARBA:ARBA00005462}.
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DR EMBL; AHAT01028878; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01028879; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01028880; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01028881; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01028882; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5MFM7; -.
DR Ensembl; ENSLOCT00000007194.1; ENSLOCP00000007186.1; ENSLOCG00000005927.1.
DR GeneTree; ENSGT00940000155773; -.
DR Proteomes; UP000018468; Linkage group LG12.
DR Bgee; ENSLOCG00000005927; Expressed in intestine and 13 other cell types or tissues.
DR GO; GO:0098609; P:cell-cell adhesion; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR028435; Plakophilin/d_Catenin.
DR PANTHER; PTHR10372:SF8; PLAKOPHILIN-4; 1.
DR PANTHER; PTHR10372; PLAKOPHILLIN-RELATED; 1.
DR Pfam; PF00514; Arm; 3.
DR SMART; SM00185; ARM; 7.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 3.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT REPEAT 538..565
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 582..625
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 840..877
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REGION 96..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 177..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 225..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1039..1089
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..207
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..482
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1039..1062
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1162 AA; 128395 MW; 3F19BA5DB822F019 CRC64;
SYPSQELQFE RLTRELEVER QIVASQLERC RLGAESPSIA SVSSSEKSFP WRSGGTTATV
CNKKPVGSKG IYCTIHIIRT EQEQVTLYSP EQASLHERSV GNSHSSTQMN SYSDSGYQET
SSYYSSQNLV KPELRLQHSF PGTSSSSTLM RSTRAEGQTL VQAPVNIAPA SARVMRRVSS
VPSRTQSPAY GSSISPSRGS LRTSLGSGYG SPAAAEPKPL ANVFSATTLP PSQSPGSPFA
AQKTGSPAAV RRVGSTNSRQ SANASRGTSP YQVLGNSARM GSPLTLVDAQ TRVGSPSHPQ
PSSSNSPVRS SMTAVPQHYG STLQRTLHHD PDPYGQQSYD IYERMIPPRP DSLTGLRSSY
ASQHSQLGQD LRSAMSPDLH ITPIYEGRTF QSPLYRSPNH GTVELHHGTQ TAVYRPSSGA
GNLQRTSSQR SAMTYQRSNY ALNTTATYAE PYRTAQYRPS ESGYSRQAVP VDDGTTRSPS
IDSIQKDPRE FAWRDPELPE VIHMLQHQFP SVQANAAAYL QHLCFGDNKV KSEVCHLGGI
KHLVDLLDHK ILEVQKNACG ALRNLVYGKA TDDNKIAVRN AGGVPALLRL LRKTVDAEVR
ELVTGVLWNL SSCDAVKMTI IRDALSTLTN TVIVPHSGWN SSSFDDDRKL KFHSSLVLRN
TTGCLRNLSS AGDEARKQMR TCEGLVDSLL YVIKACVSTS DFDSKIVENC ICTLRNLSYR
LELEMPQTRL LGTNELDGLL GNESPSKDVD SSCWGKKKKK KKKLAQDDQW DGVGPIPGFS
KPPKGVEMLW HPTVVKPYLT LLAESSNPAT LEGSAGSLQN LSAGNWKFAA YIRAAVRKEK
GLPILVELLR MDNDRVVCSV ATALRNMALD VRNKELIGKY AMRDLVNRLP GGNTTLLSDD
TVAAICCTLH EVTSKNMENA KALADTGGIE KLVNITKGRG ERYSMKVVKA AAQVLNTLWQ
YRDLRSIYKK DGWNQTHFIT PVSTLERDRY KSHPTLPTSN LQMSPVIQSA GSATSSPALL
GIKEQRSDYQ RTQPSMQFYN YQGDNNVHKS QYTGSGKPSP FYIGSYSSPP REESRRTQHQ
QLYYSQEDPS RRNYDTYKVY LQSPHSYEDP YFDEQLHYPS ATEYTSQPHG LKTTTNYVDF
YSTTRRPSYR AEQYPGSPDS WV
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