ID W5MNF6_LEPOC Unreviewed; 1014 AA.
AC W5MNF6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Gamma-tubulin complex component {ECO:0000256|RuleBase:RU363050};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000009915.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000009915.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Gamma-tubulin complex is necessary for microtubule nucleation
CC at the centrosome. {ECO:0000256|RuleBase:RU363050}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
CC -!- SIMILARITY: Belongs to the TUBGCP family.
CC {ECO:0000256|ARBA:ARBA00010337, ECO:0000256|RuleBase:RU363050}.
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DR EMBL; AHAT01003388; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006639200.1; XM_006639137.2.
DR AlphaFoldDB; W5MNF6; -.
DR STRING; 7918.ENSLOCP00000009915; -.
DR Ensembl; ENSLOCT00000009927.1; ENSLOCP00000009915.1; ENSLOCG00000008164.1.
DR GeneID; 102693646; -.
DR KEGG; loc:102693646; -.
DR CTD; 114791; -.
DR eggNOG; KOG4344; Eukaryota.
DR GeneTree; ENSGT00940000155962; -.
DR HOGENOM; CLU_011574_0_0_1; -.
DR InParanoid; W5MNF6; -.
DR OMA; RTNQFEV; -.
DR OrthoDB; 3678492at2759; -.
DR Proteomes; UP000018468; Linkage group LG17.
DR Bgee; ENSLOCG00000008164; Expressed in testis and 13 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0000923; C:equatorial microtubule organizing center; IBA:GO_Central.
DR GO; GO:0000930; C:gamma-tubulin complex; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0000922; C:spindle pole; IEA:InterPro.
DR GO; GO:0043015; F:gamma-tubulin binding; IBA:GO_Central.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IBA:GO_Central.
DR GO; GO:0051321; P:meiotic cell cycle; IBA:GO_Central.
DR GO; GO:0007020; P:microtubule nucleation; IBA:GO_Central.
DR GO; GO:0000278; P:mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0051225; P:spindle assembly; IBA:GO_Central.
DR CDD; cd22572; GCP5_NTD; 1.
DR Gene3D; 1.20.120.1900; Gamma-tubulin complex, C-terminal domain; 1.
DR InterPro; IPR007259; GCP.
DR InterPro; IPR040457; GCP_C.
DR InterPro; IPR042241; GCP_C_sf.
DR InterPro; IPR041470; GCP_N.
DR PANTHER; PTHR19302; GAMMA TUBULIN COMPLEX PROTEIN; 1.
DR PANTHER; PTHR19302:SF33; GAMMA-TUBULIN COMPLEX COMPONENT 5; 1.
DR Pfam; PF04130; GCP_C_terminal; 1.
DR Pfam; PF17681; GCP_N_terminal; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU363050};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|RuleBase:RU363050};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|RuleBase:RU363050};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT DOMAIN 268..576
FT /note="Gamma tubulin complex component protein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF17681"
FT DOMAIN 715..1007
FT /note="Gamma tubulin complex component C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04130"
FT REGION 146..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1014 AA; 117183 MW; A448F07EE0AC01EC CRC64;
MAHWTKFEKD LEIDTKRLIK LISGIQDEED QNFQMALKFA WTNFRFHRYL DVNSHKVQRT
ISGIHEKLII HSDLSKATSW KRLTEEFLNA HLPNTEGTKT ETHHSILALL LYLSDSPSNT
DYTERPRLKD AEKEDNFDWG KYLMEGEDID MGPFPDTPVW SEEESEDEDS QQPLSREDSG
IQVDKTPLDD QDHSKKTVQV SWKVGEQDAR VWLEQHVVTQ YWVAQAPHFT HSLHLHSNLL
NVWDQHLYNT DPLYLPEEKV FVTETQVIRE TLWLLSGVKK LFIFQQHEGK VTVRNDVVVT
HLTNNCLRSV LEHIAAYGQA VFRLQKFIDE VTGYNTEPAP PGTSTLSKKA SEPPFRTYQA
FVWSLYKFFI SFKEELTAIE RCILVKDKSV TLSAVLEQLT PRLAQLKVLH KVFCTGVAEV
PPGTPNVVRA SHLLNTLYKS IIEYDSIGEA SEQAVALLFS LWVETVRPYL EIVDEWIVHG
HLFDPAKEFI IQRNKDVPVD HRDFWYATYT LYSVSETVEN EEKLSDAASG SSASDPAASS
ASKQHTMVSF LKPVLKQIIM AGKSMQLLRN LHCEEDGRRE SSSRDAERKS IYTLFLESVQ
SRLCCGEESP TDTVTEQLAT KRSLIKMQSI VARHLELEDI HDPLLAINFA RLYLEQNDFH
EKFAGGDVVM DRSSESVTCQ TFELTLRSCL YPHIEKRYIE CCGNLMKTLK KDYRLVEYLQ
AMRNYFLLEA GDTMYDFYTA IFDKVLEKES WQQLSFLNVQ LQEAVGQRYP EDSTRLSILL
ETIDPARKKQ PVNNLDGLTL SYKVPWPVDI VISLECQKIY NQVFLLLLQI KWAKYSLDTL
RFNELTAATK RPEGNVFDDG AANQPVKQQI HRMFLLRVKL MHFVNSLHNY IMTRILHSTG
LEFQHQVEEA KDLDQLIKIH YRYLSTIHDR CLLREKVSFV KEAIMKVLNL ALMFSDRWQA
GFGAWKIESI DKMESDFKNC HMFLVTILNK AVCRGSFPHL ESLALSLMAG FEQC
//
