ID W5MP88_LEPOC Unreviewed; 957 AA.
AC W5MP88;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Neurofilament heavy {ECO:0000313|Ensembl:ENSLOCP00000010197.1};
GN Name=NEFH {ECO:0000313|Ensembl:ENSLOCP00000010197.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000010197.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000010197.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; AHAT01005280; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01005281; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01005282; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5MP88; -.
DR Ensembl; ENSLOCT00000010210.1; ENSLOCP00000010197.1; ENSLOCG00000008382.1.
DR GeneTree; ENSGT00940000161893; -.
DR HOGENOM; CLU_012560_7_2_1; -.
DR Proteomes; UP000018468; Linkage group LG20.
DR Bgee; ENSLOCG00000008382; Expressed in brain and 7 other cell types or tissues.
DR GO; GO:0005883; C:neurofilament; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0061564; P:axon development; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR InterPro; IPR033183; NF-H.
DR PANTHER; PTHR23214:SF1; NEUROFILAMENT HEAVY POLYPEPTIDE; 1.
DR PANTHER; PTHR23214; NEUROFILAMENT TRIPLET H PROTEIN; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT DOMAIN 77..388
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 20..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 414..957
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 81..115
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 144..220
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 272..352
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 22..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..428
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 432..475
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..591
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 719..957
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 957 AA; 106339 MW; AB1B6DADD49CB589 CRC64;
MSYTLDTLYG TTAYRKVLGD PQRNASRSSG SLTSSGFHSQ SWSRGSSASS YRRGGYSQLS
SADSLESFNG DMRSRNEKEM LQLLNDRFAG YIDKVRQLEL QNKNLEAEAA ALRQSQAGRS
AIGELYEREI TDLRSVVVQL SSEKAQVQLE QEHIEEDIQH LKQRLDDETR TRDELEAAIR
AMSKYIEESG LARLELDKKL QSLQEEAAFL KKNHEEEVGD LLSQIQGSQV TLEVRDALKA
DVTSALREIR SQLDGHTSKS AQQAEEWFKV RMEKLSEAAR FNNDAIRSAQ DEIAEYRRQL
QSRTTELETL KGTKESLERQ RCDIEDRHHS DVVSLQETIH QLDNELKSTK WEMATQLRDY
QDLLNVKMAL DIEIAAYRKL LEGEETRFTS GLGPYSYIDT TTKISTHVKV KKEDKTKVAE
KSDTVIVEEQ TDETQVTEEV TEDGEEGEKE GAEEEGKAEE EAEEEGEEAE GEAAEEKEED
VKSAGGEEEE DSKSPAGEKA ESPEPKSPAE KSPELKSPAE KSPEPKSPVE KSPELKSPAE
KSPEPKSPAE KSPEPKSPVE KSPEPKSPAE KSPEPKSPAE KSPEPKSPVE KSPEPKSPAG
KSPEPKSPVE KSPEPKSPAV KSPEPKSPAD DKAKTPAVKS LAPKPPVEDE SKKSLESKSA
AVKSPQPKSP TEDKAKSPEP KSPAETPAEG KPSTEEQVTS PAEEKSKSPR PQSPVQEKAK
SPAEEKPKPA APKAPEEEKA KTPQEEKPKE EGPQPPKDDK KKEAESKAEE KPDSKKEEKP
KDKEAVKKEE EKAPAPEEGK KESKPEEPPK KAQEPKTPTK PTEVKPEEAK EKPKAQAEEK
EKASPKAEPK EALAPAKKED TPAPKETRTE DKAEPKKEET KPEPKKEEKK PEPKEEQTKP
EPKKEETKPE PKKEEKKDVE ATKPAKKEAA DSKTQKAEKS SSTDTKETKT TEEKDKK
//
