ID W5MU37_LEPOC Unreviewed; 724 AA.
AC W5MU37;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=X-ray repair cross-complementing protein 5 {ECO:0000256|PIRNR:PIRNR016570};
DE EC=3.6.4.- {ECO:0000256|PIRNR:PIRNR016570};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000011896.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000011896.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Single-stranded DNA-dependent ATP-dependent helicase.
CC {ECO:0000256|PIRNR:PIRNR016570}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR016570}.
CC -!- SIMILARITY: Belongs to the ku80 family. {ECO:0000256|ARBA:ARBA00007726,
CC ECO:0000256|PIRNR:PIRNR016570}.
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DR EMBL; AHAT01016452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01016453; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01016454; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01016455; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015214714.1; XM_015359228.1.
DR AlphaFoldDB; W5MU37; -.
DR Ensembl; ENSLOCT00000011917.1; ENSLOCP00000011896.1; ENSLOCG00000009725.1.
DR GeneID; 102698433; -.
DR CTD; 7520; -.
DR GeneTree; ENSGT00940000153239; -.
DR HOGENOM; CLU_010975_2_1_1; -.
DR OrthoDB; 5884at2759; -.
DR Proteomes; UP000018468; Linkage group LG12.
DR Bgee; ENSLOCG00000009725; Expressed in intestine and 13 other cell types or tissues.
DR GO; GO:0043564; C:Ku70:Ku80 complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0042162; F:telomeric DNA binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd00873; KU80; 1.
DR Gene3D; 1.10.1600.10; -; 1.
DR Gene3D; 2.40.290.10; -; 1.
DR Gene3D; 1.25.40.240; Ku, C-terminal domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR InterPro; IPR024193; Ku80.
DR InterPro; IPR005160; Ku_C.
DR InterPro; IPR036494; Ku_C_sf.
DR InterPro; IPR005161; Ku_N.
DR InterPro; IPR014893; Ku_PK_bind.
DR InterPro; IPR016194; SPOC-like_C_dom_sf.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR12604; KU AUTOANTIGEN DNA HELICASE; 1.
DR PANTHER; PTHR12604:SF4; X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5; 1.
DR Pfam; PF02735; Ku; 1.
DR Pfam; PF03730; Ku_C; 1.
DR Pfam; PF03731; Ku_N; 1.
DR Pfam; PF08785; Ku_PK_bind; 1.
DR PIRSF; PIRSF016570; Ku80; 1.
DR SMART; SM00559; Ku78; 1.
DR SUPFAM; SSF101420; C-terminal domain of Ku80; 1.
DR SUPFAM; SSF100939; SPOC domain-like; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR016570};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR016570};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172,
KW ECO:0000256|PIRNR:PIRNR016570};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|PIRNR:PIRNR016570};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR016570};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PIRNR:PIRNR016570};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR016570};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR016570};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR016570};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT DOMAIN 298..437
FT /note="Ku"
FT /evidence="ECO:0000259|SMART:SM00559"
FT REGION 174..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 542..563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 724 AA; 81945 MW; 90108462FAC8449F CRC64;
MARSNKSALV LCMDVGLSMS NSAPGQESPF DQAKKVIQKF VQRQVFAENK DELALVLLGT
NQTKNSLASD GQYQNIFVHR HLMIPDFNLL EEIQNGIHPG DQQADFLDGL IVCMDLLQKE
TLGKKYERLN IVMLTDLYSP ASLDQLDTII ENLKRTGITL QFILPFSLDL EDASRSSGDA
GDPRSPHYSG KGLTQEQREG VKIVRQIMTS LDEEDGLDEV HIFSEAIEHL SIFKKIERRP
MAWPCQLTIG SSISIRIVGY KAVTEEKIKK NWMMVEAQTQ KKDDVKRETV YCLNDDQETE
VAKDDTIQGF RYGSDIVPFS KVDQEQMKYK SDGKCFAVLG FTKQNQFQRH LFMGSQVVKV
FAPKGDEHAA VALSALIHAL DELQMVAVVR YAYDKRANPQ VGAAFPCIKD KYECLMYVQL
PYMEDLRQFI FPSLENSKKF ALSEEQLSAV DSLIDSMMLV EEEDGETADL FKVNKMANPQ
FQRLFQCLHH RALNPSAPLP PVEPWLKEVL ERPQAVTARC QASLKELQGR FPLKEAIRKK
ETKTSADIFG NEEEPDSKKP KLEKDEEFKL TEISDGTITA VGSVDPSRDF RFLVCQKSLP
FGQVCEQLTH RIEQLLCNKS TQFYLKSFSC IQAFREQSIQ VGEPTIYNDY LQSLKRSIQD
RGLQGFWELL VKDNISLISK DEVECSAVSK AEADQFLAAE EKPALETGPI ADEEGDVDDL
LDMM
//
