ID W5MUR5_LEPOC Unreviewed; 1961 AA.
AC W5MUR5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000012124.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000012124.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR EMBL; AHAT01010434; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01010435; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015209750.1; XM_015354264.1.
DR STRING; 7918.ENSLOCP00000012124; -.
DR Ensembl; ENSLOCT00000012145.1; ENSLOCP00000012124.1; ENSLOCG00000009914.1.
DR GeneID; 102683457; -.
DR CTD; 566868; -.
DR eggNOG; KOG2301; Eukaryota.
DR GeneTree; ENSGT00940000154992; -.
DR InParanoid; W5MUR5; -.
DR OMA; FTEMEQD; -.
DR OrthoDB; 1110761at2759; -.
DR Proteomes; UP000018468; Linkage group LG9.
DR Bgee; ENSLOCG00000009914; Expressed in heart and 5 other cell types or tissues.
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IBA:GO_Central.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IBA:GO_Central.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR024583; Na_trans_cytopl.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF288; SODIUM CHANNEL PROTEIN; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR Pfam; PF11933; Na_trans_cytopl; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SMART; SM00015; IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50096; IQ; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 126..149
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 225..246
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 252..272
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 392..419
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 715..733
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 745..768
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 825..853
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 913..938
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1144..1163
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1184..1202
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1270..1296
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1353..1372
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1393..1416
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1475..1493
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1505..1527
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1539..1558
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1606..1628
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1696..1719
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 129..425
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 521..664
FT /note="Voltage-gated Na+ ion channel cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF11933"
FT DOMAIN 714..944
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 952..1139
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 1143..1425
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1474..1729
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 32..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 462..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1048..1091
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1907..1926
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1938..1961
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 427..457
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 485..510
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1063..1091
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1909..1926
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1947..1961
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1961 AA; 223485 MW; C4F9D674B5031679 CRC64;
MATLLLPPGP DSLRRFTRES LAAIENRIAE EQARNAKQEY REDLGDVEPP KPRADLEAGK
QLPRIFGDIP SELVGVPLDD FDSYYYNNQK TFIVLNKGKA IFRFSATPAL YIFSPFHPVR
RASIKILVHS LFSLFIMCTI LTNCVFMAMS EPAQWAKYVE YTFTGIYTFE SLIKILARGF
CIGPFTFLRD PWNWLDFSVI VMAYVTEFVD LGNVSALRTF RVLRALKTIS VIPGLKTIVG
ALIQSVKKLA DVMILTVFCL SVFALIGLQL FMGNLRQKCV QNITDCYHNT STNGTNYYCK
NKTWPSYQDF ISDEENYYKL EGAKDPLLCG NGSDAGRCPD GAVCLKIGKN PDYGYTSFDT
FGWAFLALFR LMTQDYWENL YHQTLRSVGK TYMIFFVLVI FLGSFYLINL ILAVVAMAYE
EQNQATIAEA WQKEKEFQEA MEQLRKEQQA IVNKVQETDS VLSPEMSPFP MKDTKERRNR
KKKHKTLSEG AEDDAEDKTA KQDTEDRQRG NVFLARTLSS ANRRESQCSI FNFRSRNKES
ETDFADDECS ANGDNASRTG SLVIPWSRRR TSAHSTSSHC SQGNTPTLNI NGKLNITVDR
NGVSSLGPPS ALTLPVVMVD KVNTEDHMLN CTNETSNMLN PRRFSAAEFL EEPFQRERAL
SAASVLTNAM EELEESHQKC HPCWYRFAQH YLIWDCCPLW LKIKEWVKFG VMDPFLDLAI
TICIVLNTLF MALEHHPMTD DFNSMLSVGN LVFTGIFTAE MVFKIIALDP YYYFQQGWNI
FDSIIVSLSL MELGLSNVEG LSVLRSFRLL RVFKLAKSWP TLNTLIKIIG NSVGALGNLT
LVLAIIVFIF AVVGMQLFGK SYQDCVCKIS KDCTLPRWHM KDFFHSFLIV FRVLCGEWIE
TMWDCMEVAG QPLCILVFML VMVIGNLVVL NLFLALLLSS FSADNLSAPD DDGEMNNLQI
AIARIQRGIN WLKIAICDFF NGNFKKRRQK AKEAKAMTKL QRLGNHIEGN GTMGIIGRNG
EKYVISDGDS YMTNPNLTIN VPIAPGESDV EFPEEDERSE CSEDEEVKQK DEISLSEGST
VDLRKPGEEE DEFSEMAEEA MDPEDCFPEM CVRRFPCCDI NTTQGVGSIW WRLRKTCYRI
VEHSWFETFI IFMILLSSGA LAFEDINIEK RKVIKVILEY ADKVFTYVFV LEMLLKWVAY
GFKKYFTNYW CWLDFLIVDI STDTAFDRVS LISLIANTLG YSDFAAIKSL RTLRALRPLR
ALSRFEGMRV VVNALIGAIP SIMNVLLVCL IFWLIFSIMG VNLFAGKFGK CVSKAGYQYN
ASHINNRSEC LAMNNMTLYY WTKVKVNFDN VGAGYLALLQ VATFKGWMEI MYAAVDSRGL
EEQPIKESNL YMYLYFVIFI IFGSFFTLNL FIGVIIDNFN QQKRKLGGQD IFMTEEQKKY
YNAMKKLGSK KPQKPIPRPL NPFQGFFFDV VSKQAFDIII MILICLNMVT MMVETDDQSK
RMEDILNKIN LAFIVIFTGE CCIKIMALRC YFFTVGWNIF DFVVVILSIV GIVLADIIEK
YFVSPTLFRV IRLARIGRVL RLIRGAKGIR TLLFALMMSL PALFNIGLLL FLVMFIYAIF
GMANFAYVKK QGGIDDMFNF ETFGNSMICL FQITTSAGWD SLLSPILNNS PEECDANKTH
TGTNAKGDCG NPSVGITFFV SYIIISFLIV VNMYIAIILE NFSVATEEST EPLSEDDFEM
FYEVWEKFDP EATQFIEYAK LSDFADSLEE PLRIAKPNKI KLISMDLPMV SGDKIHCLDI
LFAFTKRVLG ESGEMDALKQ QMEEKFMMAN PSKISYEPIT TTLRRKQEEV SAVIIQRAYR
RHLLRRSMRQ ASFLYRHINS DGNIDVEDPP EKEGLIASMI KENYGHETEM TETLSSTSSP
PSYDSVTRAT SDIFQVVISD PRNTDQSEPF IHPDRDRESF L
//
