ID W5MV42_LEPOC Unreviewed; 433 AA.
AC W5MV42;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=EGF-like-domain, multiple 6 {ECO:0000313|Ensembl:ENSLOCP00000012251.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000012251.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000012251.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the nephronectin family.
CC {ECO:0000256|ARBA:ARBA00009738}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AHAT01012853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5MV42; -.
DR Ensembl; ENSLOCT00000012272.1; ENSLOCP00000012251.1; ENSLOCG00000010006.1.
DR GeneTree; ENSGT00930000150973; -.
DR Proteomes; UP000018468; Linkage group LG14.
DR Bgee; ENSLOCG00000010006; Expressed in larva and 11 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd06263; MAM; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR000998; MAM_dom.
DR PANTHER; PTHR24050:SF24; EPIDERMAL GROWTH FACTOR-LIKE PROTEIN 6; 1.
DR PANTHER; PTHR24050; PA14 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF00629; MAM; 1.
DR PRINTS; PR00020; MAMDOMAIN.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00137; MAM; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS50060; MAM_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT DOMAIN 65..103
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 110..148
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 282..427
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
SQ SEQUENCE 433 AA; 48149 MW; 13579AA1325D5D1E CRC64;
MNTHGSYMCY CLNGYMLMAD GSCANSRTCI MAHCQYGCEE VQGEVRCLCP SAGLQLGPDE
RTCVDVDECS TGKRLCPYNR RCVNTFGSYY CKCQIGFDLE YVDGKYDCVD VDECASNTHK
CSPQAQCLNT HGSYKCKCKP GFRGSGFDCS AIPDSPSKES PRILGNGKDP LTKLVVDNNR
ELEGEQRKNV IPEPQPTAPP KNRLQPFDYE DGIYIGGSVE EKDPEDDVFL EEEDNLENQI
ESKETSRRGD VFIPEEYKSV IGRLTVTKEA PAVVPGHEEF IIDCSFNQGA CEWMQDTEDD
FDWSVADHDN GIGYYMAVPG FVGERKDVGR LKLLLSDSAS QSGFCLTFNY RLIGERIGKL
RILLDDSGSP LWERSKSRDE SWQTELVTVS WSKAAPEHVV FEAERGKGKA GEIGLDDVVL
TSGSCQEDDS VVF
//
