ID W5N2W2_LEPOC Unreviewed; 976 AA.
AC W5N2W2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=GPI ethanolamine phosphate transferase 2 {ECO:0000256|ARBA:ARBA00020830};
GN Name=PIGG {ECO:0000313|Ensembl:ENSLOCP00000014971.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000014971.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000014971.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
CC {ECO:0000256|ARBA:ARBA00005315}.
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DR EMBL; AHAT01017779; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01017780; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01017781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01017782; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01017783; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5N2W2; -.
DR STRING; 7918.ENSLOCP00000014971; -.
DR Ensembl; ENSLOCT00000015000.1; ENSLOCP00000014971.1; ENSLOCG00000012169.1.
DR eggNOG; KOG2125; Eukaryota.
DR GeneTree; ENSGT00910000144269; -.
DR HOGENOM; CLU_004770_4_0_1; -.
DR InParanoid; W5N2W2; -.
DR OMA; RVKFGHD; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000018468; Linkage group LG4.
DR Bgee; ENSLOCG00000012169; Expressed in ovary and 12 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051267; F:CP2 mannose-ethanolamine phosphotransferase activity; IBA:GO_Central.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IBA:GO_Central.
DR CDD; cd16024; GPI_EPT_2; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR002591; Phosphodiest/P_Trfase.
DR InterPro; IPR037674; PIG-G_N.
DR InterPro; IPR039527; PIGG/GPI7.
DR InterPro; IPR045687; PIGG/GPI7_C.
DR PANTHER; PTHR23072:SF0; GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2; 1.
DR PANTHER; PTHR23072; PHOSPHATIDYLINOSITOL GLYCAN-RELATED; 1.
DR Pfam; PF01663; Phosphodiest; 1.
DR Pfam; PF19316; PIGO_PIGG; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 469..494
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 506..536
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 686..704
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 710..735
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 747..765
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 875..900
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 912..936
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 948..968
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 641..955
FT /note="GPI ethanolamine phosphate transferase 2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19316"
SQ SEQUENCE 976 AA; 109194 MW; 733166D5FD4D34AA CRC64;
MKIRSSVFAS LCLVIEVFGI VLFLRGFFPV PVKSSLSSKS KVSDLPLEPL EGHAANSSRI
PPPLFKRVVI MLVDALREDF VFGPKGKEFM PYTRHLVERG SSHSFVAKAR APTVTMPRIK
ALTTGSIPGF IDVVMNLNSP ALQEDNLIWQ AKTAGKKVVF YGDDTWIRLF PKHFMEYDGT
TSFFVSDYTE VDNNVTRHLD STLKRDDWDV LILHYLGLDH IGHLSGPHSS LIGPKLLEMD
DILKKIHTAL ISKVKHGLLK NLLKMCVEHS RSNIPLCSGS SQLKLSGHPF ALLVLIASYF
KTVRIGFETP EPVEQVDFTP TLALGLGLPI SQNNVGHLIL PVFEENTLRE QLRFLHLNGF
QLSHLIKDST PDFEKDPGYE QFRIAEKSHG SWMKLYLEGN TSEVLSNMGK KVLKQYMDAL
KSMSESLSKQ LGKYDMYSMI VGMSIVLEVL FLLLITMAEA LSGAAEVDLP LSSALCSLPF
YLLCLFCSSI HVMVCTSTES TCYFCSLSWA LVFAVIAFFS SLLCVILSII GRKLFWAKPQ
MKNILKAQSS DSGFSELDIL LLTGTLGHVL SLGASSFIEE EHQTWYFLLN TLCLAVFQDV
CRKYFREKKS HRDLDENSYL PSKDDTPTVD YSSRTSALAG YEKWLALVTP LATLVCCRML
RSLNQTGVQW AHLPDLGHWL NNSEHIVELS LLAAASLVLI FLLVQRRCSL VSKIALGLGL
LGVYSYRAAV GNVLFPWQQD GRDISKGTVE ARFVYIFVLG ILFTGAKDLL RSQVISSDTQ
LKSRGLWEIY SGVVLLAALL FRPHNLPVLL FCLLIQTIMA QFIWKELQYD AAQTTIMHYW
FGQAFLYFQG NSNNIATVDI SAGFVGLENY VEIPAIFLTA FCTYAGPLLW ACHLVCYLSS
ERERSTAAIG HGCYCFALLR SIPAAAYIIL VTALRYHLFI WSVFSPKLLY EGMHTLVTAA
VCVFFTAMDQ NHAVRT
//
